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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 7 of 7. This is the beginning of the thread.
Posted by denise1966 on August 28, 2005, at 12:32:28
Hi Scott,
Hope your feeling better, are you?
Sorry to ask you in particular but you always give such sound advice and it was you who responded to my question about going on Seroxat after a trial of Nardil.
Well I'm now on the Nardil, have been for over a week and have been feeling really awful on it, thank God for Zyprexa, because I don't know where I'd be now without it.
Well anyway, I'm going on the fact that the Seroxat seemed to work better last time after I'd been on Nardil for about three weeks before, now this just might have been purely co-incidence I don't know.
Anyway, I was wondering if it would make any difference whether I was on it for a week or three weeks before going back on the Seroxat as I'm getting anxious to try it again and I really don't like the way I'm feeling on this Nardil but then again I didn't particularly like the way I was feeling before so doesn't make that much difference.
Kind Regards....Denise
Posted by SLS on August 28, 2005, at 13:05:43
In reply to To SLS, posted by denise1966 on August 28, 2005, at 12:32:28
Hi Denise.
If your goal is to provoke the brain into making adjustments to the Nardil as a pretreatment in preparation for a cross-over to Seroxat, I think you will need to wait 3 weeks. Of course, scientists don't yet understand what these adjustments and compensations by the brain are in response to exposure to antidepressants, but receptors have a turnover rate of approximately 2 weeks.
I understand your strategy.
Good luck.
- Scott> Hi Scott,
>
> Hope your feeling better, are you?
>
> Sorry to ask you in particular but you always give such sound advice and it was you who responded to my question about going on Seroxat after a trial of Nardil.
>
> Well I'm now on the Nardil, have been for over a week and have been feeling really awful on it, thank God for Zyprexa, because I don't know where I'd be now without it.
>
> Well anyway, I'm going on the fact that the Seroxat seemed to work better last time after I'd been on Nardil for about three weeks before, now this just might have been purely co-incidence I don't know.
>
> Anyway, I was wondering if it would make any difference whether I was on it for a week or three weeks before going back on the Seroxat as I'm getting anxious to try it again and I really don't like the way I'm feeling on this Nardil but then again I didn't particularly like the way I was feeling before so doesn't make that much difference.
>
>
> Kind Regards....Denise
Posted by denise1966 on August 28, 2005, at 13:57:31
In reply to Re: To SLS, posted by SLS on August 28, 2005, at 13:05:43
Scott,
Thanks, I'll hang on for at least two weeks then. How are you feeling anyway and what are you taking now?
Denise
Posted by denise1966 on August 28, 2005, at 14:27:34
In reply to Re: To SLS - Thanks so much, posted by denise1966 on August 28, 2005, at 13:57:31
Scott,
Would Zyprexa stop that turnover rate of receptors or hinder it in anyway do you know?
Denise
Posted by SLS on August 28, 2005, at 15:01:50
In reply to Re: To SLS - Sorry last thing I promise, posted by denise1966 on August 28, 2005, at 14:27:34
Hi Denise.
:-)
> Would Zyprexa stop that turnover rate of receptors or hinder it in anyway do you know?
I wouldn't think so. Remember, the combination of Prozac + Zyprexa (Symbiax) still results in the resolution of depression, so my guess is that Zyprexa does not affect the therapeutic brain adaptations provoked by Prozac. I can't imagine that the same would not be true of Nardil or Seroxat.
I am not feeling my worst at the moment. However, the response I had last week to Keppra was at the time very encouraging. I was elated at the thought of the response continuing in that manner indefinitely and finally beginning to live a life with energy and reward. It stopped working, though, and I have not had enough of a demonstration that the antidepressant response will return. I have been at the lower dosages, though, and I look forward to having my doctor increase it up to 2000mg. Unfortunately, it has been my experience that once I begin to respond to a medication and then stop responding (tachyphylaxis), no dosage increase recaptures the antidepressant response. I wish I had happier news. At least I took advantage of the three days I was improved. I can accomplished more in three days while feeling well than I can in a year feeling ill. I'm sure you know that from personal experience. I'm pretty bummed-out.
- Scott
P.S. You ask all the right questions. I only wish I had all the right answers. Your intellect is impressive.
Posted by denise190466 on August 29, 2005, at 10:39:08
In reply to Re: To SLS - Sorry last thing I promise » denise1966, posted by SLS on August 28, 2005, at 15:01:50
Scott,
I'm so sorry that Keppra hasn't continued to work for you, it must be so frustrating to have this keep happening. You must wonder why, have you ever thought of having a Pet Scan before and after you get a response to find out what's happening? Or would that be too expensive and don't you think it would be of any use? How bad would you say your depression was right now? Are you able to function ok? If I remember rightly you said that you suffered from Bipolar Disorder? Doesn't this mean that you will go up again as part of the cycle?
It makes me sick that these type of scans aren't part of the normal procedure for anyone suffering from psychiatric illnesses. I'm sure they'd find out more if they made it standard practice to do a Pet/Spect Scan of anyone suffering from depression before and after treatment. I guess it would be too expensive though.
I wish I'd had one done when my antidepressants worked years ago to find out what was going on in my brain now they don't work. I'm really starting to believe that I have less Serotonin transporters than I did then and that my brain has shrunk.
I'm starting to think about having a scan before and after taking Zyprexa as this is the only drug I can really count on to help me. It scares me to think where I'd be without it.
Anyway, thanks for the compliment regarding my intellect but all I do is ask stupid questions out of sheer frustration, you're the one who provides the answers.
Kind Regards.......Denise
Posted by ed_uk on August 29, 2005, at 12:18:36
In reply to Re: To SLS - Sorry last thing I promise, posted by denise190466 on August 29, 2005, at 10:39:08
Hi Denise,
I just posted to you about atypical antipsychotics above :-) Just didn't want you to miss the post.
Ed x
This is the end of the thread.
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