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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 12 of 12. This is the beginning of the thread.
Posted by superman on June 9, 2005, at 5:52:06
3 and a half weeks on parnate and I'm feeling good. Virtually no negative side-effects for the first three weeks. The only thing I really noticed in that time was being less tired in the morning, which was a good start since I began to actually get up in the moring, although my mood didnt seem any better.
At 3 1/2 weeks I'm feeling good. I feel motivated. I actually feel like there is things worth doing each day. I feel much less likely to get discouraged about things I want or need to do.
These past 3 days have been a little strange however. I've slept only 3 hours the past 3 nights, and all of that was on monday night.
I've also had a pretty constant headache. It doesn't help with trying to get to sleep.
I started exercising for the first time in a long when this started, as well as eating very differently. I'm wondering if these things are making the parnate insomia worse??? (maybe just increased metabolism from the exercise, or maybe its the whey protein (tyramine content?), or perhaps the chromium I'm supplementing). I got my blood pressure checked yeserday, and it was ok at the time.
Anyway, I'm worried about not getting any sleep. What's my best option here? What works best for other people? Trazodone- how safe is that taking with a MAOI? I've tried trazodone before, and it left me with a brutal headache. Wouldn't that be worse in combo with the parnate? Melatonin - seems its not recommended for ppl with mood disorders?? Klonopin - will that leave me tired the next morning, or feeling down again? But then, maybe it will help with social anxiety? Ambien - don't know much about this. Is it true it shouldn't be taken for more than a few weeks?
Sorry for the long post, but thats where I'm at, and any thoughts on the insomnia/headache problem would be great. Thanks,
T
Posted by Bill LL on June 9, 2005, at 7:17:14
In reply to parnate, motivation, and insomnia, posted by superman on June 9, 2005, at 5:52:06
I think the best for sleep is Lunesta because it keeps working at the same dose over the long term and doesn't cause next day tiredness.
Posted by Declan on June 9, 2005, at 15:26:47
In reply to parnate, motivation, and insomnia, posted by superman on June 9, 2005, at 5:52:06
Some protein powder things have free form amino acids in them. On a dose of only 2mg deprenyl/d they keep me awake. If it's just whey protein, I dunno....
How much Parnate are you on? How did your dosing schedule go? Just curious. Would like to start it myself, but as my sleep is so bad already I would have to try a pretty small dose.
Declan
Posted by linkadge on June 9, 2005, at 17:29:23
In reply to Re: parnate, motivation, and insomnia, posted by Declan on June 9, 2005, at 15:26:47
I'd try reducing the chromium, seems it might be a little too activating with parnate.
Linkdge
Posted by Maxime on June 9, 2005, at 17:30:25
In reply to parnate, motivation, and insomnia, posted by superman on June 9, 2005, at 5:52:06
I don't know if anyone will agree with me, but 12-25 mg of Thorazine would really help. It has a long half-life. When I get a headache from Parnate I take 12 mg and it is the only thing that works. So if you took it at night, chance are you wouldn't get the headaches at all. 12 mg is a very small dose. You don't have to worry about TD or anything like that.
I would take it every night if i could because it made me feel "balanced", but it makes me lactate so I can't.
Maxime
Posted by Phillipa on June 9, 2005, at 18:01:24
In reply to Re: parnate, motivation, and insomnia » superman, posted by Maxime on June 9, 2005, at 17:30:25
I'd listen to Maxime. I think we should rename her the Parnate Queen! We have Ace the Nardil Champ! What do you think Maxie? Queen Maxime. Has a nice ring to it. Fondly, Phillipa
Posted by linkadge on June 9, 2005, at 19:13:23
In reply to Re: parnate, motivation, and insomnia, posted by Phillipa on June 9, 2005, at 18:01:24
Yes, parnate can be very stimulating, which can lead to insomnia.
Low dopamine contributes to relaxation at bedtime, and sleep. You could try taking all your parnate in the morning, and a low dose AP at night.
Linkadge
Posted by superman on June 10, 2005, at 7:09:48
In reply to Re: parnate, motivation, and insomnia, posted by Declan on June 9, 2005, at 15:26:47
> How much Parnate are you on? How did your dosing schedule go? Just curious. Would like to start it myself, but as my sleep is so bad already I would have to try a pretty small dose.
> DeclanHi Declan. Thanks for the post. I'm only at 30mg, which so far seems like more than enough. I take 20mg upon waking, and 10mg in the afternoon. I took 20mg the first two weeks, and noticed a dramatic change in my sleeping habits even on that. It is very stimulating as people have said.
T
Posted by superman on June 10, 2005, at 7:16:58
In reply to Re: parnate, motivation, and insomnia, posted by linkadge on June 9, 2005, at 19:13:23
Thanks so much everyone for your help.
hmmm, still haven't slept since monday night. I better make a doctors appointment. I have a good supply of trazodone already on me, but I've read mixed opinions about its use with a MAOI.
Oh well, here we go...
Posted by Maxime on June 10, 2005, at 11:19:09
In reply to Re: parnate, motivation, and insomnia, posted by superman on June 10, 2005, at 7:16:58
> Thanks so much everyone for your help.
>
> hmmm, still haven't slept since monday night. I better make a doctors appointment. I have a good supply of trazodone already on me, but I've read mixed opinions about its use with a MAOI.
>
> Oh well, here we go...BTW, did you get some emergency pills to take in case you have a reaction to something?
Many people get Thorazine. If you did, you should try it to sleep.
Yup, make sure you get some pills.
Maxime
Posted by Ktemene on June 11, 2005, at 17:34:44
In reply to parnate, motivation, and insomnia, posted by superman on June 9, 2005, at 5:52:06
It's great that Parnate is working out for you!
A headache on starting a new AD is pretty common; it should go away in time.
Exercise should not increase your insomnia, unless you are doing the exercise very late at night. In fact, exercise should help you sleep. If you are worried that your whey protein is keeping you awake, you might try switching to a whey protein that has a higher proportion of tryptophan. Melatonin does make some people depressed, but others are fine with it. Trazodone is used with MAOI's, but if you don't like it, you might try low dose (e.g. 15 mg) Remeron, or Lunesta as Bill suggested. Lunesta is a new drug that is approved as a long term sleep aid; Benzos are not, although they are often used long term. Klonopin has the longest half-life of all of the Benzos, so it will probably make you tired in the morning when you first begin taking it, but lots of people get over this effect. Viridis is a poster who has a lot of information about Klonopin and had a good experience with it. You might search for his posts if you are interested in Klonopin.
Posted by Levi on June 15, 2005, at 20:01:51
In reply to Re: parnate, motivation, and insomnia, posted by Ktemene on June 11, 2005, at 17:34:44
Just to let you guys know, you can't take Parnate in combination with trazodone or remeron because it will cause an interaction and possibly a hypertensive crisis because remeron is a tetracyclic antidepressant and I beleive trazodone is a tricyclic.
Thanks,
Levi
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