![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by WeeWilly on March 29, 2005, at 13:39:43
For at least 18 years now I have been treated with Parnate each spring. I found out that 3 months is all it is good for even if I add other meds to it. I sure never thought I would still be seeking an effective treatment after all these years. You would think I would stumble on to something that would have long term effectiveness. For the first time this winter I had a bad reaction to a treatment. I was takeing Cymabalta, Nuerontin and Mirapex and became extremely dizzy in Dec and still have'nt totally recovered.
Suffering for as long as I have has made me investigate to determine what is likely wrong with my biochemistry. It was back in 1987 when I read an article that told about a hormonal protein called Inhibin B that had been identified. It got my interest because the known role of Inhbin B fit into the puzzle of my cyclic symptoms. Mind you at that time they did not think it had anything to do with mood. Now I think they are on the verge of identifying that Inhibin B has a role in mood. I've tried to influence researchers through the years to investigate in this area but as far as I can tell it has fell on deaf ears. Allthough I am quite certain this is the key to my disorder I really do not know how many of you suffer the same low production of Inhibin B. Could be allot.
I have posted this story here before and other places. In many ways my situation and perspective on my situation is so different from others who suffer from mood disorders that I think you have a hard time relating to me. It's odd and frustating to see that low Inhibin B production is likely my problem and can not do anything about it because everyone in research just can't see it. In the early 1990's the endocrine dept. at the UW in Seattle was looking into Inhibin B as a potential male contraceptive. I was hopeing it would become available for that and I could use to elevate my level to correct my mood and cognition. Alas they dropped their studies of it for its use as a contraceptive because they found levels of Inhibin B far larger in brain and spinal fluid than they expected. They concluded that Inhibin B had a much more significant role in the CNS than was understood then. That larger role still has'nt been totally identified, but they are getting closer. The breakthrough will likely come in studies being done in mood problems in menopausal women. Those studies consistently monitor Inhibin levels. They allways find them drastically reduced in menopause but discount its significance. They seem to be getting close to putting 2 + 2 together and with other research see that Inhibin B is a factor that should not be ignored. I realize I probably come off as being irrational to many of you but I have just followed were the evidence has led me.
Your ideas on my predicament would be appreciated. Thanks
Posted by Maxime on March 29, 2005, at 14:22:52
In reply to Annual Parnate treatment, posted by WeeWilly on March 29, 2005, at 13:39:43
OMG. I stopped Parnate for over a month because it pooped out on me. Actually it was probably 2 months. Then I tried Nardil and had a reaction (dizzy throwing up). So I waited until my system cleared and I tried the Parnate again. I became hypertensive at 10 mg. I had a headached so bad that I had to take Thorazine. I was dizzy and nauseous. I used be on a dosage of 80 mg and could eat anything I wanted (cheese, red wine, yogurt ...) figured I had a high tolerance for tyramine. Even when I first started Parnate over 2 years ago I was able to titrate quickly to 100 mg (then brought it down to 80). I tried it again two days later and the same thing happened.
I asked my doctor today why this would happen. He said it was biochemical (well no sh*t Sherlock). He couldn't tell me why. I'm baffled. I hope someone can answer your question because I want to know as well.
Maxime
> For at least 18 years now I have been treated with Parnate each spring. I found out that 3 months is all it is good for even if I add other meds to it. I sure never thought I would still be seeking an effective treatment after all these years. You would think I would stumble on to something that would have long term effectiveness. For the first time this winter I had a bad reaction to a treatment. I was takeing Cymabalta, Nuerontin and Mirapex and became extremely dizzy in Dec and still have'nt totally recovered.
> Suffering for as long as I have has made me investigate to determine what is likely wrong with my biochemistry. It was back in 1987 when I read an article that told about a hormonal protein called Inhibin B that had been identified. It got my interest because the known role of Inhbin B fit into the puzzle of my cyclic symptoms. Mind you at that time they did not think it had anything to do with mood. Now I think they are on the verge of identifying that Inhibin B has a role in mood. I've tried to influence researchers through the years to investigate in this area but as far as I can tell it has fell on deaf ears. Allthough I am quite certain this is the key to my disorder I really do not know how many of you suffer the same low production of Inhibin B. Could be allot.
> I have posted this story here before and other places. In many ways my situation and perspective on my situation is so different from others who suffer from mood disorders that I think you have a hard time relating to me. It's odd and frustating to see that low Inhibin B production is likely my problem and can not do anything about it because everyone in research just can't see it. In the early 1990's the endocrine dept. at the UW in Seattle was looking into Inhibin B as a potential male contraceptive. I was hopeing it would become available for that and I could use to elevate my level to correct my mood and cognition. Alas they dropped their studies of it for its use as a contraceptive because they found levels of Inhibin B far larger in brain and spinal fluid than they expected. They concluded that Inhibin B had a much more significant role in the CNS than was understood then. That larger role still has'nt been totally identified, but they are getting closer. The breakthrough will likely come in studies being done in mood problems in menopausal women. Those studies consistently monitor Inhibin levels. They allways find them drastically reduced in menopause but discount its significance. They seem to be getting close to putting 2 + 2 together and with other research see that Inhibin B is a factor that should not be ignored. I realize I probably come off as being irrational to many of you but I have just followed were the evidence has led me.
> Your ideas on my predicament would be appreciated. Thanks
Posted by WeeWilly on March 29, 2005, at 17:09:05
In reply to Re: Annual Parnate treatment, posted by Maxime on March 29, 2005, at 14:22:52
The mode of action of psychoactive meds are so so mysterious. Fifty years from now absolutely none of the current ad's with be used. Some how some way we have to hang a few more years. Probably each of us will stumble onto a treatment that makes life close to liveable, then eventually psychiatry will come out of the dark ages and understanding of the biochemical problems that cause mood disorders will be elucidated and appropriate treatment will be developed.
Monominergic theories that try to explain mood disorders as an imbalance of seretonin, ne,or dopamine are riduclous. They might explain some sufferers disorder, but they might not explain any.
Maxime have you ever seen an endocronologist? The ones I have seen were helpfull to a point. I would like to hook up with a neuroendocrologist, but they seem to be very rare.
Many people feel the bain imaging techniques being developed are a great advancement. But these are used to direct a patient to the current med's available. Since the current med's are crap for many of us, I don't see this as much of a breakthough. The effecacy of ad's have not improved in fifty years. That is a fact and quite pathetic. Keep fighting. Best wishes.
Posted by Phillipa on March 29, 2005, at 17:23:04
In reply to Re: Annual Parnate treatment, posted by WeeWilly on March 29, 2005, at 17:09:05
And each day another med is pulled because of side effects that were not identified before the med was released. Fondly, Phillipa
Posted by Maxime on March 29, 2005, at 19:36:15
In reply to Re: Annual Parnate treatment, posted by WeeWilly on March 29, 2005, at 17:09:05
I agree with you 100 percent. If my depression was merely an imbalance of Serotonin, NE, and dopomine, the ADs would work.
I think my problems are more metabolic in nature. I see an endocrinologist because I am hypothyroid. But I am not impressed with him. I show signs of hypothroidism yet my tests come back normal ( I am on Synthroid). He isn't doing all the right tests. He doesn't test my Free T3 and Free T4. I also believe I have adrenal problems. But because I have a psych history I get funny looks from him when I suggest these things. I'm sure he thinks I am a hypochondriac. So he doesn't do much for me and doesn't listen to anything I say. I'm pretty much used to it by now. In fact once I telling my GP some stuff and I threw in "and Mary had a little lamb" and she didn't blink an eye. I will have to try the same with him and see if hears me.
Do doctors receive any training in communication and how to LISTEN to their patients?
Nope, psychiatry hasn't advanced that much for the past 45-50 years. The pharmaceutical industry sure is growing though, isn't it?
Maxime
> The mode of action of psychoactive meds are so so mysterious. Fifty years from now absolutely none of the current ad's with be used. Some how some way we have to hang a few more years. Probably each of us will stumble onto a treatment that makes life close to liveable, then eventually psychiatry will come out of the dark ages and understanding of the biochemical problems that cause mood disorders will be elucidated and appropriate treatment will be developed.
> Monominergic theories that try to explain mood disorders as an imbalance of seretonin, ne,or dopamine are riduclous. They might explain some sufferers disorder, but they might not explain any.
> Maxime have you ever seen an endocronologist? The ones I have seen were helpfull to a point. I would like to hook up with a neuroendocrologist, but they seem to be very rare.
> Many people feel the bain imaging techniques being developed are a great advancement. But these are used to direct a patient to the current med's available. Since the current med's are crap for many of us, I don't see this as much of a breakthough. The effecacy of ad's have not improved in fifty years. That is a fact and quite pathetic. Keep fighting. Best wishes.
Posted by ixus on March 30, 2005, at 2:23:07
In reply to Re: Annual Parnate treatment » WeeWilly, posted by Maxime on March 29, 2005, at 19:36:15
> Nope, psychiatry hasn't advanced that much for the past 45-50 years. The pharmaceutical industry sure is growing though, isn't it?
>
> MaximeExplanation is quite simple. If nothing works, everything what is never, can be a better placebo. That is what the pharma lobby is based on. The funny thing is that many (young) pdocs believe in that even though they don't have mental problems ;-)
/ixus
This is the end of the thread.
Psycho-Babble Medication | Extras | FAQ
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.org
Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.