Posted by Maxime on March 29, 2005, at 14:22:52
In reply to Annual Parnate treatment, posted by WeeWilly on March 29, 2005, at 13:39:43
OMG. I stopped Parnate for over a month because it pooped out on me. Actually it was probably 2 months. Then I tried Nardil and had a reaction (dizzy throwing up). So I waited until my system cleared and I tried the Parnate again. I became hypertensive at 10 mg. I had a headached so bad that I had to take Thorazine. I was dizzy and nauseous. I used be on a dosage of 80 mg and could eat anything I wanted (cheese, red wine, yogurt ...) figured I had a high tolerance for tyramine. Even when I first started Parnate over 2 years ago I was able to titrate quickly to 100 mg (then brought it down to 80). I tried it again two days later and the same thing happened.
I asked my doctor today why this would happen. He said it was biochemical (well no sh*t Sherlock). He couldn't tell me why. I'm baffled. I hope someone can answer your question because I want to know as well.
Maxime
> For at least 18 years now I have been treated with Parnate each spring. I found out that 3 months is all it is good for even if I add other meds to it. I sure never thought I would still be seeking an effective treatment after all these years. You would think I would stumble on to something that would have long term effectiveness. For the first time this winter I had a bad reaction to a treatment. I was takeing Cymabalta, Nuerontin and Mirapex and became extremely dizzy in Dec and still have'nt totally recovered.
> Suffering for as long as I have has made me investigate to determine what is likely wrong with my biochemistry. It was back in 1987 when I read an article that told about a hormonal protein called Inhibin B that had been identified. It got my interest because the known role of Inhbin B fit into the puzzle of my cyclic symptoms. Mind you at that time they did not think it had anything to do with mood. Now I think they are on the verge of identifying that Inhibin B has a role in mood. I've tried to influence researchers through the years to investigate in this area but as far as I can tell it has fell on deaf ears. Allthough I am quite certain this is the key to my disorder I really do not know how many of you suffer the same low production of Inhibin B. Could be allot.
> I have posted this story here before and other places. In many ways my situation and perspective on my situation is so different from others who suffer from mood disorders that I think you have a hard time relating to me. It's odd and frustating to see that low Inhibin B production is likely my problem and can not do anything about it because everyone in research just can't see it. In the early 1990's the endocrine dept. at the UW in Seattle was looking into Inhibin B as a potential male contraceptive. I was hopeing it would become available for that and I could use to elevate my level to correct my mood and cognition. Alas they dropped their studies of it for its use as a contraceptive because they found levels of Inhibin B far larger in brain and spinal fluid than they expected. They concluded that Inhibin B had a much more significant role in the CNS than was understood then. That larger role still has'nt been totally identified, but they are getting closer. The breakthrough will likely come in studies being done in mood problems in menopausal women. Those studies consistently monitor Inhibin levels. They allways find them drastically reduced in menopause but discount its significance. They seem to be getting close to putting 2 + 2 together and with other research see that Inhibin B is a factor that should not be ignored. I realize I probably come off as being irrational to many of you but I have just followed were the evidence has led me.
> Your ideas on my predicament would be appreciated. Thanks
poster:Maxime
thread:477238
URL: http://www.dr-bob.org/babble/20050326/msgs/477255.html