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Dr. Bob is Robert Hsiung, MD,
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Posted by ed_uk on January 1, 2005, at 16:48:32
Hello,
Has anyone tried both of these medications? How did their effects compare? What did you take them for?
I noticed that there have been quite a lot of posts about adrafinil in the past, has anyone taken it recently?
Thanks,
Ed.
Posted by Michael Bell on January 1, 2005, at 19:16:26
In reply to Adrafinil (Olmifon) and Modafinil (Provigil), posted by ed_uk on January 1, 2005, at 16:48:32
> Hello,
>
> Has anyone tried both of these medications? How did their effects compare? What did you take them for?
>
> I noticed that there have been quite a lot of posts about adrafinil in the past, has anyone taken it recently?
>Hey ed,
Adrafinil can be a great adjunctive medication, at least as far as SP is concerned. It helps with focus and is particularly good when added with Klonopin and/or prozac. Problem is it can be quite pricey, the effects are not consistent, tolerance builds up rather quickly, and it can cause hyperfocusing. It's one of those drugs that feels like its really working one day then its like a sugar pill the next. This is all from personal experience, by the way.
> Thanks,
> Ed.
Posted by pablo1 on January 22, 2005, at 0:00:06
In reply to Adrafinil (Olmifon) and Modafinil (Provigil), posted by ed_uk on January 1, 2005, at 16:48:32
I just got some a few days ago. It's amazing how similar it is to other meds based on the NT effects. Tastes a lot like the norepenephrine effect of Wellbutrin to me plus the GABA effect of neurontin/phenibut. I am not real excited initially. It's also similar to the effect of stimulants plus benzos which is sort of middle-ground drugged. Supposedly Provigil does not give a 'high' but only promotes wakefullness; adrafinil achieves this through a combo of stimulant/sedative effect. I don't know, it kind of left me feeling odd. I was worried that it would cause insomnia but that wasn't a problem due to the perhaps mildly ghb-like GABA sleepfullness effect.
Posted by jujube on January 22, 2005, at 16:02:16
In reply to Re: Adrafinil (Olmifon) and Modafinil (Provigil), posted by pablo1 on January 22, 2005, at 0:00:06
I have been doing research on Provigil as well as gathering information on people's experiences with the drug as I am hoping to use it to augment the Celexa I am on.
If you don't mind, could you please tell me what you mean by "it left me feeling odd"? Also, in the short time you have been on it, have you noticed an effect in terms of motivation and mood brightening? Finally, what dose are you currently using?
Thanks in advance.
> I just got some a few days ago. It's amazing how similar it is to other meds based on the NT effects. Tastes a lot like the norepenephrine effect of Wellbutrin to me plus the GABA effect of neurontin/phenibut. I am not real excited initially. It's also similar to the effect of stimulants plus benzos which is sort of middle-ground drugged. Supposedly Provigil does not give a 'high' but only promotes wakefullness; adrafinil achieves this through a combo of stimulant/sedative effect. I don't know, it kind of left me feeling odd. I was worried that it would cause insomnia but that wasn't a problem due to the perhaps mildly ghb-like GABA sleepfullness effect.
Posted by pablo1 on January 22, 2005, at 16:51:36
In reply to Re: Adrafinil (Olmifon) and Modafinil (Provigil) » pablo1, posted by jujube on January 22, 2005, at 16:02:16
Sorry I guess 'feel odd' is a bit ambiguous. I could definitely feel something but it didn't feel stimulating like wellbutrin, ritalin, etc nor was it sedating like knonopin, neurontin, etc. But, I could feel it, maybe a little detatched feeling.
My issue is depression with a bit of ADHD & I'm not that depressed, my real problem is computer/internet addiction leaving me totally unmotivated. I didn't get the sense that this stuff was making me want to get up & go at all, but nothing really seems to help with that much.
I did have some good results from amisulpride & ameneptine boosting my sense for pleasure, for instance, I went out & got a guitar & started playing that & enjoying it & listening to music. But those also did kind of get me a bit 'high' & not always thinking real straight. The adanafril doesn't cloud my head like that, just a bit of sensation in my body & the 'taste' of both wellbutrin & neurontin. By taste, I mean literally and also similar feeling. I guess I was feeling a bit of the stimulation like wellbutrin but maybe the sedating effect left it overall neutral.
I only tried for a few days between 150 & 600mg (1/2 to 2 tabs). I guess I've given up because I could feel it was doing something but I didn't particularly like anything about it & couldn't sense any improvement or potential for such. It stays in my system for at least a couple days somewhat.
Other people said it's better combined with other meds & not so special by itself so maybe I'll try it again with something else like amisulpride or ritalin. I didn't have any bad side effects though, just felt sort of uneasy that it was noticeable in my system having some effect. My doc wants me to try Strattera & that has all sorts of common bad side effects so I thought I'd try this first. Both are popular for not having any euphoric 'high' effect but still improving concentration/motivation.
Anyways, maybe that gives you some clue how I felt on adrafinil.
> I have been doing research on Provigil as well as gathering information on people's experiences with the drug as I am hoping to use it to augment the Celexa I am on.
>
> If you don't mind, could you please tell me what you mean by "it left me feeling odd"? Also, in the short time you have been on it, have you noticed an effect in terms of motivation and mood brightening? Finally, what dose are you currently using?
>
> Thanks in advance.
>
> > I just got some a few days ago. It's amazing how similar it is to other meds based on the NT effects. Tastes a lot like the norepenephrine effect of Wellbutrin to me plus the GABA effect of neurontin/phenibut. I am not real excited initially. It's also similar to the effect of stimulants plus benzos which is sort of middle-ground drugged. Supposedly Provigil does not give a 'high' but only promotes wakefullness; adrafinil achieves this through a combo of stimulant/sedative effect. I don't know, it kind of left me feeling odd. I was worried that it would cause insomnia but that wasn't a problem due to the perhaps mildly ghb-like GABA sleepfullness effect.
>
>
Posted by ed_uk on January 22, 2005, at 16:59:35
In reply to Re: Adrafinil (Olmifon) and Modafinil (Provigil), posted by pablo1 on January 22, 2005, at 16:51:36
You got 'high' on amisulpride??? What do you mean?
Ed.
Posted by pablo1 on January 22, 2005, at 18:52:57
In reply to Re: Adrafinil (Olmifon) and Modafinil (Provigil) » pablo1, posted by ed_uk on January 22, 2005, at 16:59:35
> You got 'high' on amisulpride???
> What do you mean?Yes, it's a stimulant rather like amphetamine at low doses (I don't know about high doses for antipsychotic treatment) but without the jittery norepenephrine, just the euphoric dopamine effect. I don't know if it's comparable for abusing but somewhat similar. I'm not fond of speed for getting high anyways. What I'm talking about though is 'cognitive impairment' like drinking makes you stupid & slow. amisulpride did make me kind of dizzy headed like that somewhat.
Posted by jujube on January 22, 2005, at 20:14:35
In reply to Re: Adrafinil (Olmifon) and Modafinil (Provigil), posted by pablo1 on January 22, 2005, at 16:51:36
Posted by ed_uk on January 23, 2005, at 9:22:03
In reply to Re: Adrafinil (Olmifon) and Modafinil (Provigil), posted by pablo1 on January 22, 2005, at 18:52:57
Hello,
What dose of amisulpride did you take? Did it loose it's effect over time?
Regards,
Ed.
Posted by pablo1 on January 23, 2005, at 10:42:20
In reply to Re: Solian » pablo1, posted by ed_uk on January 23, 2005, at 9:22:03
About 25mg each of amisulpride & amineptine for more than a month I think before I ran out. I don't think they lost effectiveness though I was less 'happy' toward the end. Maybe the ameneptine had some tolerance but the amisulpride tended to just give me that dizzy spacey feeling rather than happy but you know there is just so much a pill can do when I continue to sit on my *ss & procrastinate my life away. I played with larger doses without many major dramatic effects, still fairly subtle speedy feeling with an odd feeling of pressure on my heart though my blood pressure checked out OK. I never had trouble sleeping on these either. I also tried ritalin in the same period & that was definitely more abusable with a more obvious effect but the amisulpride was more of a smooth euphoric happy pill, less 'wired' feeling. I found I was content with ami at a very low dose.
I read about one guy with a history of stimulant abuse & mild psychosic problems in AU prescribed amisulpride & he thought his doc was crazy because it felt like cocaine for the first month or so at high dose of maybe 300mg but he said that wore off. At doses above 300mg it reduces dopamine, maybe he should have had even more & was at the top pro-dopamine dose. I tried maybe 150mg & didn't think it was that great but it did feel very speedy & too much so for my taste. About 25mg was very nice subtle happy pill, more than that made me not-so-clear-thinking. Ritalin was less subtle & nice, yet more tempting to overdo. Amineptine was less of a euphoric happy pill but still smoother than ritalin & combined nicely with amisulpride. Alone at low doses it had little effect but was quite speedy at higher doses.
A couple glasses of wine with amisulpride & I was feeling very good. A bottle or more of wine & some extra ami & I tended to stumble, slurr & pass out (which I never do otherwise).
Posted by ed_uk on January 23, 2005, at 11:04:39
In reply to Re: Solian, posted by pablo1 on January 23, 2005, at 10:42:20
Hi pablo1!
Thank you for the information :-)
Did you ever take the amisulpride alone or did you always take it with amineptine?
Did you feel 'spaced out' even at doses as low as 25mg amisulpride?
Regards,
Ed.
Posted by pablo1 on January 23, 2005, at 13:58:13
In reply to Re: Solian » pablo1, posted by ed_uk on January 23, 2005, at 11:04:39
Yes I tried them alone though not much. I thought amisulpride was more spacey/euphoric & ameneptine had a 'thinner' feeling, the amisulpride was more rich but maybe the more 'sensible' feeling of the amineptine counterbalanced that. At low doses the spacey feeling was no problem at all until I got more depressed & lethargic then I guess it might have made me feel a little helpless, you know like even yummy food doesn't satisfy sometimes it just makes you nauseous. But I really wasn't trying at all to get off my butt and I guess no pill is going to do that for me. A little bit of ADD & a lot of bad habits & laziness, it's hard not to get kind of depressed, plus too much drinking. When I went out & did things I still liked these meds though. I probably wouldn't have quit had I not run out.
The wife called them my 'happy pills'.
Posted by ed_uk on January 23, 2005, at 14:26:09
In reply to Re: Solian, posted by pablo1 on January 23, 2005, at 13:58:13
Hi pablo1,
>A little bit of ADD & a lot of bad habits & laziness
What effect (if any) would you say 25mg of amisulpride had on your motivation and concentration/attention? Did it make you more lazy or less lazy?
Also, what did you mean when you said that the high dose of amisulpride was speedy? I thought you found that it made you feel spaced out.
Why aren't you taking amisulpride anymore? Isn't it available in the country where you live?
>The wife called them my 'happy pills'.
Well, in some countries amisulpride is approved for the treatment of depression! Here in the UK it's just used for schizophrenia.
Thanks for your help,
Ed.
Posted by pablo1 on January 23, 2005, at 17:40:20
In reply to Re: Solian » pablo1, posted by ed_uk on January 23, 2005, at 14:26:09
> What effect (if any) would you say 25mg of
> amisulpride had on your motivation and
> concentration/attention?
> Did it make you more lazy or less lazy?Well, my attention problems have more to do with avoiding things I don't like to do so maybe it's not even ADHD at all (though that scenario is also described). That said, it helped at high doses while driving all day but not as much as ritalin and for motivation, yes it motivated me to enjoy myself more like playing the guitar though I did go back to being a zombie in front of the computer even before I ran out.
>
> Also, what did you mean when you said that the
> high dose of amisulpride was speedy?
> I thought you found that it made you feel spaced out.
Just like too high a dose of ritalin gets you high & makes you speedy. Therapeutic dose helps concentration, too much impairs thinking.>
> Why aren't you taking amisulpride anymore?
> Isn't it available in the country where you live?
> Well, in some countries amisulpride is approved for the treatment of depression! Here in the UK it's just used for schizophrenia.
Nope, not approved for anything here.: - (
Posted by ed_uk on January 24, 2005, at 6:54:05
In reply to Re: Solian, posted by pablo1 on January 23, 2005, at 17:40:20
Hi,
>Well, my attention problems have more to do with avoiding things I don't like to do....
Yes, me too. Have you found a solution? Have you found anything better than Ritalin? Have you ever tried selegiline?
>Nope, not approved for anything here.
What country?
Best Regards,
Ed.
Posted by pablo1 on January 24, 2005, at 8:21:32
In reply to Re: Solian » pablo1, posted by ed_uk on January 24, 2005, at 6:54:05
> > Well, my attention problems have more to do
> > with avoiding things I don't like to do....
>
> Yes, me too. Have you found a solution?
> Have you found anything better than Ritalin?
> Have you ever tried selegiline?
Segeline sounds interesting though the MAOI thing is scary.
I'm at a loss, ritalin is kind of nice (amisulpride is nicer)
but doesn't do much for avoidance.
I'm in the US.
Posted by ed_uk on January 24, 2005, at 9:23:17
In reply to Re: Solian, posted by pablo1 on January 24, 2005, at 8:21:32
Hi,
Have you tried to order the amisulpride from abroad? Have you ever tried sulpiride?
Ed.
Posted by pablo1 on January 24, 2005, at 10:47:25
In reply to Re: Solian » pablo1, posted by ed_uk on January 24, 2005, at 9:23:17
I got them overpriced from Canada, shipped through the US, amisulpride no longer available.
I have not tried sulpride.
Posted by ed_uk on January 24, 2005, at 11:06:36
In reply to Re: Solian, posted by pablo1 on January 24, 2005, at 10:47:25
Hi,
Sulpiride is available in many more countries than amisulpride so perhaps it would be easier to get hold of.
25mg amisulpride is similar to 50mg sulpiride
Here is a lost of countries where sulpiride is used...........
The symbol ¤ denotes a preparation which is discontinued or no longer actively marketed.
Arg.: Nivelan; Vipral;
Austria: Dogmatil; Meresa;
Belg.: Dogmatil; Levopraid;Braz.: Dogmatil; Equilid;
Chile: Aplacid; Dislep; Sanblex; Sulpilan;
Denm.: Dogmatil; Sulpril¤;
Fin.: Suprium;
Fr.: Aiglonyl; Dogmatil; Synedil;
Ger.: Arminol; Desisulpid¤; Dogmatil; Intrasil¤; Meresa; neogama D novo; neogama; Sulp;
Sulpivert; Vertigo-Meresa; vertigo-neogama;Gr.: Calmoflorine; Darleton; Dogmatyl; Eclorion; Noneston; Nufarol; Nylipark; Restful; Stamoneyrol; Valirem;
Hong Kong: Dogmatil; Sulpiren¤;
Hung.: Depral;
Irl.: Dolmatil;
Israel: Modal;
Ital.: Championyl; Confidan¤; Dobren; Equilid; Eusulpid¤; Isnamide¤; Levobren; Levopraid; Normum¤; Quiridil¤;
Jpn: Dogmatyl;
Mex.: Dogmatil¤; Ekilid; Pontiride; Rimastine;
Neth.: Dogmatil;
Port.: Dogmatil; Lisopride;
S.Afr.: Depex¤; Eglonyl; Espiride;
Singapore: Dogmatil¤;
Spain: Digton; Dixibon¤; Dogmatil; Guastil;
Lebopride; Mirbanil¤; Pausedal; Psicocen; Sulkine; Tepavil;Switz.: Dogmatil;
UK: Dolmatil; Sulparex¤; Sulpitil; Sulpor.
Ed.
Posted by pablo1 on January 24, 2005, at 12:37:27
In reply to Re: Solian » pablo1, posted by ed_uk on January 24, 2005, at 11:06:36
Jeeze, all those places but not the US.
Thanks for the suggestion. Does sulpiride have the same effect of pro-dopamine at low doses, anti-dopamine at higher doses? What I could find seemed to imply it's just an antagonist but had the different dosage for depression vs AP. What is the difference?
Posted by lars1 on January 25, 2005, at 5:42:02
In reply to Re: Solian » pablo1, posted by ed_uk on January 24, 2005, at 11:06:36
> Gr.: Calmoflorine; Darleton; Dogmatyl; Eclorion; Noneston; Nufarol; Nylipark; Restful; Stamoneyrol; Valirem;
These must be the strangest medication names I have ever heard. Why would anybody want to take 'Dogmatyl'?
> Ital.: Championyl; Confidan¤; Dobren; Equilid; Eusulpid¤; Isnamide¤; Levobren; Levopraid; Normum¤; Quiridil¤;Championyl, I would take.
Lars
Posted by ed_uk on January 25, 2005, at 9:18:14
In reply to Re: Solian, posted by pablo1 on January 24, 2005, at 12:37:27
Hi,
>Does sulpiride have the same effect of pro-dopamine at low doses, anti-dopamine at higher doses?
Yes, this is thought to be the case. From PubMed... 'At low dosages (50 to 150 mg/day), sulpiride produces a disinhibiting and antidepressant effect, which is probably related to its action on D2 presynaptic autoreceptors, thus facilitating dopaminergic neurotransmission.'
Also... 'Dopamine release can be modulated by ....... inhibitory presynaptic D2 receptors since ....... sulpiride....... elevated stimulation-induced dopamine release.'
What I could find seemed to imply it's just an antagonist but had the different dosage for depression vs AP. What is the difference?Sulpiride is thought to act as an antidepressant at low doses by increasing dopamine release.
Ed.
Posted by ed_uk on January 25, 2005, at 9:19:35
In reply to Re: Dogmatyl » ed_uk, posted by lars1 on January 25, 2005, at 5:42:02
Hi,
I guess the Italians have more style!
Ed.
Posted by michael on December 5, 2005, at 20:07:23
In reply to Re: Solian » pablo1, posted by ed_uk on January 24, 2005, at 11:06:36
Ed-
Just wondering if you might have a list (like the one below) of countries where amisulpride is available?
...any other/additional suggestions regarding where these two meds might be found would also be appreciated. Thanks for any feedback, or further info.
michael
mplsmtl@uscorp.net> Hi,
>
> Sulpiride is available in many more countries than amisulpride so perhaps it would be easier to get hold of.
>
> 25mg amisulpride is similar to 50mg sulpiride
>
> Here is a lost of countries where sulpiride is used...........
>
> The symbol ¤ denotes a preparation which is discontinued or no longer actively marketed.
>
> Arg.: Nivelan; Vipral;
>
> Austria: Dogmatil; Meresa;
>
> Belg.: Dogmatil; Levopraid;
>
> Braz.: Dogmatil; Equilid;
>
> Chile: Aplacid; Dislep; Sanblex; Sulpilan;
>
> Denm.: Dogmatil; Sulpril¤;
>
> Fin.: Suprium;
>
> Fr.: Aiglonyl; Dogmatil; Synedil;
>
> Ger.: Arminol; Desisulpid¤; Dogmatil; Intrasil¤; Meresa; neogama D novo; neogama; Sulp;
> Sulpivert; Vertigo-Meresa; vertigo-neogama;
>
> Gr.: Calmoflorine; Darleton; Dogmatyl; Eclorion; Noneston; Nufarol; Nylipark; Restful; Stamoneyrol; Valirem;
>
> Hong Kong: Dogmatil; Sulpiren¤;
>
> Hung.: Depral;
>
> Irl.: Dolmatil;
>
> Israel: Modal;
>
> Ital.: Championyl; Confidan¤; Dobren; Equilid; Eusulpid¤; Isnamide¤; Levobren; Levopraid; Normum¤; Quiridil¤;
>
> Jpn: Dogmatyl;
>
> Mex.: Dogmatil¤; Ekilid; Pontiride; Rimastine;
>
> Neth.: Dogmatil;
>
> Port.: Dogmatil; Lisopride;
>
> S.Afr.: Depex¤; Eglonyl; Espiride;
>
> Singapore: Dogmatil¤;
>
> Spain: Digton; Dixibon¤; Dogmatil; Guastil;
> Lebopride; Mirbanil¤; Pausedal; Psicocen; Sulkine; Tepavil;
>
> Switz.: Dogmatil;
>
> UK: Dolmatil; Sulparex¤; Sulpitil; Sulpor.
>
> Ed.
Posted by ed_uk on December 6, 2005, at 13:54:54
In reply to Re: Solian » ed_uk, posted by michael on December 5, 2005, at 20:07:23
Hi Michael
Amisulpride is available in Italy, Portugal, France, the UK etc. Lots of places really except in the US!
Regards
Ed
PS. Amisulpride and sulpiride are both available as generics in the UK.
This is the end of the thread.
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