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Re: Sulpiride » pablo1

Posted by ed_uk on January 25, 2005, at 9:18:14

In reply to Re: Solian, posted by pablo1 on January 24, 2005, at 12:37:27

Hi,

>Does sulpiride have the same effect of pro-dopamine at low doses, anti-dopamine at higher doses?

Yes, this is thought to be the case. From PubMed... 'At low dosages (50 to 150 mg/day), sulpiride produces a disinhibiting and antidepressant effect, which is probably related to its action on D2 presynaptic autoreceptors, thus facilitating dopaminergic neurotransmission.'

Also... 'Dopamine release can be modulated by ....... inhibitory presynaptic D2 receptors since ....... sulpiride....... elevated stimulation-induced dopamine release.'


What I could find seemed to imply it's just an antagonist but had the different dosage for depression vs AP. What is the difference?

Sulpiride is thought to act as an antidepressant at low doses by increasing dopamine release.

Ed.


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URL: http://www.dr-bob.org/babble/20050124/msgs/447335.html