Psycho-Babble Medication Thread 367535

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Maprotiline (Ludiomil) - Comments?

Posted by SLS on July 18, 2004, at 20:34:18

Maprotiline (Ludiomil)

This is one of the few drugs I haven't tried. I keep forgetting about it.


- Scott

 

Re: Maprotiline (Ludiomil) - Comments?

Posted by KaraS on July 18, 2004, at 21:47:48

In reply to Maprotiline (Ludiomil) - Comments?, posted by SLS on July 18, 2004, at 20:34:18

> Maprotiline (Ludiomil)
>
> This is one of the few drugs I haven't tried. I keep forgetting about it.
>
>
> - Scott


I took a small amount of it for many years to help me sleep and prevent panic attacks. It had far fewer side effects (at least for me) and was mildly sedating (didn't leave me as groggy in the morning as doxepin had). It worked for me on the level that I used it for. I don't know about its efficacy as an AD but it may be worth trying - esp. considering it's tolerability. The only downside is it lowers the seizure threshold more - in line with Wellbutrin - so not excessively.

-k

 

Re: Maprotiline (Ludiomil) - Comments?

Posted by zeebop on July 19, 2004, at 6:39:54

In reply to Re: Maprotiline (Ludiomil) - Comments?, posted by KaraS on July 18, 2004, at 21:47:48

I took 25-50mg of Ludiomil with Prozac for a few monthes,and it got rid of prozac-induced anxiety,insomnia and cold feet...I think it is the most selective NE in the market (even more than reboxetine),and has mild antihistaminic effects(good for sleep-bad for weight),and very mild AC effect....it was one of the easiest AD to take for me,and I think it is hardly mentioned now because it is cheap,but it was one of the best selling AD's in europe before the "SSRIs revoluotion!"

 

Re: Maprotiline (Ludiomil) - Comments?

Posted by King Vultan on July 19, 2004, at 7:32:19

In reply to Maprotiline (Ludiomil) - Comments?, posted by SLS on July 18, 2004, at 20:34:18

> Maprotiline (Ludiomil)
>
> This is one of the few drugs I haven't tried. I keep forgetting about it.
>
>
> - Scott

The receptor chart in "Psychotropic Drugs" shows it as a selective NE reuptake inhibitor similar to desipramine or nortriptyline but somewhat more sedating. Structurally, it is a secondary amine similar in that way to those two drugs--no doubt, this is where the NE selectivity comes from--but it is a non-tricyclic, having a weird bridged center ring. There is a superficial resemblance to a tricyclic, however.

Todd

 

Re: Maprotiline (Ludiomil) - Comments?

Posted by KaraS on July 19, 2004, at 16:26:11

In reply to Re: Maprotiline (Ludiomil) - Comments?, posted by King Vultan on July 19, 2004, at 7:32:19

> > Maprotiline (Ludiomil)
> >
> > This is one of the few drugs I haven't tried. I keep forgetting about it.
> >
> >
> > - Scott
>
> The receptor chart in "Psychotropic Drugs" shows it as a selective NE reuptake inhibitor similar to desipramine or nortriptyline but somewhat more sedating. Structurally, it is a secondary amine similar in that way to those two drugs--no doubt, this is where the NE selectivity comes from--but it is a non-tricyclic, having a weird bridged center ring. There is a superficial resemblance to a tricyclic, however.
>
> Todd


Actually I think I've seen it referred to as a tetracyclic.

 

Re: Maprotiline (Ludiomil) - Comments? KaraS

Posted by King Vultan on July 19, 2004, at 17:20:10

In reply to Re: Maprotiline (Ludiomil) - Comments?, posted by KaraS on July 19, 2004, at 16:26:11

> > > Maprotiline (Ludiomil)
>
>
> Actually I think I've seen it referred to as a tetracyclic.

Yes, or heterocyclic. Technically, there are four rings in maprotiline because the bridge cuts the center ring in half. However, just glancing at the thing, it very much resembles a typical tricyclic. OTOH, the amoxapine and mirtazapine structures resemble tricyclic structures with another ring attached--I think both of these could also be called tetracyclic if one wanted to.

Todd


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