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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by jlbl2l on April 27, 2004, at 1:02:07
chemist,
can you please site some references (proefessional pref.) articles etc.. or trials on xanax being investigated or used as an anti-depressant because of your thoughts on its 5ht and probably d2 activating/binding? I've researched on the net, newsgroups etc , and the closest thing i could find is a small article noting its effects (but only concerning anxiety/panic) on norep. and sero. ->
http://www3.interscience.wiley.com/cgi-bin/abstract/66004550/ABSTRACT
It also mentions some other "intriguing" benzos that I have not heard of. comments?
all the best :-)
jlbl2l
P.S. - Working On that email to you...
Posted by chemist on April 27, 2004, at 1:21:07
In reply to chemist, references... on xanax's anti-d effects.?, posted by jlbl2l on April 27, 2004, at 1:02:07
> chemist,
>
> can you please site some references (proefessional pref.) articles etc.. or trials on xanax being investigated or used as an anti-depressant because of your thoughts on its 5ht and probably d2 activating/binding? I've researched on the net, newsgroups etc , and the closest thing i could find is a small article noting its effects (but only concerning anxiety/panic) on norep. and sero. ->
>
> http://www3.interscience.wiley.com/cgi-bin/abstract/66004550/ABSTRACT
>
> It also mentions some other "intriguing" benzos that I have not heard of. comments?
>
> all the best :-)
> jlbl2l
> P.S. - Working On that email to you...rickels and rynn, j. clin. psy. 2002; neuropharmacology 43:1269-1279, 2002;
am. fam. physician 66:1239-1248, 2002;
behav. pharmacol. 3:229-237, 1992;
psychopharmacology (berlin) 148:146-152, 2000;
...and the list goes on and on......all the best, chemist
Posted by SLS on April 27, 2004, at 6:13:33
In reply to chemist, references... on xanax's anti-d effects.?, posted by jlbl2l on April 27, 2004, at 1:02:07
> can you please site some references (proefessional pref.) articles etc.. or trials on xanax being investigated or used as an anti-depressant
I haven't really studied the proposed mechanisms by which Xanax (alprazolam) exerts its antidepressant effects, but it definitely does, how ever mild these effects may be. Even more intriguing is a drug called adinazolam (Deracyn). Both Xanax and adinazolam belong to the subfamily of benzodiazepines known as triazalobenzodiazepines. Adinazolam is an antidepressant devoid of hypnotic and sedative properties. It can be quite energizing. I guess these two triazalo's have some pharmacodynamic properties in common. The other triazolo currently available is triazolam (Halcion), which is the most potent of the benzodiazepines. It has not demonstrated any antidepressant effects that I know of.
- Scott
Posted by chemist on April 27, 2004, at 16:37:42
In reply to Re: chemist, references... on xanax's anti-d effects.?, posted by SLS on April 27, 2004, at 6:13:33
> > can you please site some references (proefessional pref.) articles etc.. or trials on xanax being investigated or used as an anti-depressant
>
>
> I haven't really studied the proposed mechanisms by which Xanax (alprazolam) exerts its antidepressant effects, but it definitely does, how ever mild these effects may be. Even more intriguing is a drug called adinazolam (Deracyn). Both Xanax and adinazolam belong to the subfamily of benzodiazepines known as triazalobenzodiazepines. Adinazolam is an antidepressant devoid of hypnotic and sedative properties. It can be quite energizing. I guess these two triazalo's have some pharmacodynamic properties in common. The other triazolo currently available is triazolam (Halcion), which is the most potent of the benzodiazepines. It has not demonstrated any antidepressant effects that I know of.
>
>
> - Scott
>
>
>
>
>
hi there, from chemist....the other triazolobenzodiazepene (in addition to the 3 named above) is estazolam....as for adinazolam being devoid of sedative or hypnotic effects, there is a wealth of literature that indicate otherwise. i note that adinazolam is not the active drug with affinity for the benzodiazepine site(s): it is N-desmethyladinazolam, and it has a very short half-life, which might be why one is tempted to say that the use of the parent drug is devoid of sedative/hypnotic effects. if y'all need references, let me know.....all the best, chemist
Posted by SLS on April 27, 2004, at 17:50:24
In reply to Re: chemist, references... on xanax's anti-d effects.? » SLS, posted by chemist on April 27, 2004, at 16:37:42
> ..as for adinazolam being devoid of sedative or hypnotic effects, there is a wealth of literature that indicate otherwise.That was not my experience with this drug. I was treated with adinazolam in 1985. Unfortunately, I don’t remember the dosages used, so I can’t comment on the drug’s behavior throughout its clinical range. With respect to sedative and hypnotic effects, it didn’t affect me in the slightest. It was incredible. The drug was remarkably clean. That isn’t to say that it doesn’t possess anxiolytic properties. It probably does. On this, I can’t comment either since I did not suffer from anxiety at the time.
> i note that adinazolam is not the active drug with affinity for the benzodiazepine site(s): it is N-desmethyladinazolam, and it has a very short half-life, which might be why one is tempted to say that the use of the parent drug is devoid of sedative/hypnotic effects. if y'all need references, let me know.....all the best, chemist
Sure. I’d love to see some more stuff about adinazolam. It is a very interesting drug that should probably have been pursued further.
- Scott
Posted by chemist on April 27, 2004, at 23:05:06
In reply to Re: chemist, references... on xanax's anti-d effects.?, posted by SLS on April 27, 2004, at 17:50:24
>
> > ..as for adinazolam being devoid of sedative or hypnotic effects, there is a wealth of literature that indicate otherwise.
>
> That was not my experience with this drug. I was treated with adinazolam in 1985. Unfortunately, I don’t remember the dosages used, so I can’t comment on the drug’s behavior throughout its clinical range. With respect to sedative and hypnotic effects, it didn’t affect me in the slightest. It was incredible. The drug was remarkably clean. That isn’t to say that it doesn’t possess anxiolytic properties. It probably does. On this, I can’t comment either since I did not suffer from anxiety at the time.
>
> > i note that adinazolam is not the active drug with affinity for the benzodiazepine site(s): it is N-desmethyladinazolam, and it has a very short half-life, which might be why one is tempted to say that the use of the parent drug is devoid of sedative/hypnotic effects. if y'all need references, let me know.....all the best, chemist
>
> Sure. I’d love to see some more stuff about adinazolam. It is a very interesting drug that should probably have been pursued further.
>
>
> - Scott
>
hi scott, sounds like you were in the early days of trials after upjohn released....my info comes (mostly) from www.pubmed.org on this one, single keyword adinazolam, and you can peruse abstracts that support your claims as well as those that supprt mine...all the best, chemist
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