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Re: chemist, references... on xanax's anti-d effects.? SLS

Posted by chemist on April 27, 2004, at 16:37:42

In reply to Re: chemist, references... on xanax's anti-d effects.?, posted by SLS on April 27, 2004, at 6:13:33

> > can you please site some references (proefessional pref.) articles etc.. or trials on xanax being investigated or used as an anti-depressant
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> I haven't really studied the proposed mechanisms by which Xanax (alprazolam) exerts its antidepressant effects, but it definitely does, how ever mild these effects may be. Even more intriguing is a drug called adinazolam (Deracyn). Both Xanax and adinazolam belong to the subfamily of benzodiazepines known as triazalobenzodiazepines. Adinazolam is an antidepressant devoid of hypnotic and sedative properties. It can be quite energizing. I guess these two triazalo's have some pharmacodynamic properties in common. The other triazolo currently available is triazolam (Halcion), which is the most potent of the benzodiazepines. It has not demonstrated any antidepressant effects that I know of.
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> - Scott
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hi there, from chemist....the other triazolobenzodiazepene (in addition to the 3 named above) is estazolam....as for adinazolam being devoid of sedative or hypnotic effects, there is a wealth of literature that indicate otherwise. i note that adinazolam is not the active drug with affinity for the benzodiazepine site(s): it is N-desmethyladinazolam, and it has a very short half-life, which might be why one is tempted to say that the use of the parent drug is devoid of sedative/hypnotic effects. if y'all need references, let me know.....all the best, chemist


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