![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 11 of 11. This is the beginning of the thread.
Posted by McPac on May 27, 2003, at 21:21:56
I've been reading Dr. Heller's site......he says that some folks have an overactive 5HT1a receptor which can cause generalized anxiety....he says that when these people take SSRI's that all serotonin receptors become activated, including the 5HT1a receptors...this makes those people even MORE anxious, irritable, or angry.....so, I need to know what effect Remeron has on 5HT1a receptors---does it BLOCK those receptors OR does it further activate those receptors? Very important to me...please help if you can...Thanks!
Posted by ace on May 27, 2003, at 22:13:35
In reply to Need some help....really appreciate an answer!, posted by McPac on May 27, 2003, at 21:21:56
> I've been reading Dr. Heller's site......he says that some folks have an overactive 5HT1a receptor which can cause generalized anxiety....he says that when these people take SSRI's that all serotonin receptors become activated, including the 5HT1a receptors...this makes those people even MORE anxious, irritable, or angry.....so, I need to know what effect Remeron has on 5HT1a receptors---does it BLOCK those receptors OR does it further activate those receptors? Very important to me...please help if you can...Thanks!
Made a note of this and will print out. Will go through my psychopharmacology books tonight. Will have answer tommorrow.
You are a legend, McPac!
BTW, any thoughts about going to Nardil again?
Ace.
Posted by McPac on May 27, 2003, at 23:01:26
In reply to Re: Need some help....really appreciate an answer! » McPac, posted by ace on May 27, 2003, at 22:13:35
Ace, GREAT to hear that your Nardil is working so well for you!
I've been searching the 'net and it looks like Remeron indirectly acts as a partial agonist at the 5HT1a receptor site. So that should be pretty good for me (that should lessen anxiety). The ssri's have the opposite effect at that site; by raising serotonin at all sites, they increase or further activate that site (making some people feel worse anxiety/anger). I'm so glad that the Nardil is working so good for you Ace---if I were you I'd stay on it for life! I did briefly take Nardil many years ago and it worked VERY GOOD for me too....but I was always so afraid of eating anything...I was afraid I'd eat something that would cause problems....I remember my doctor at the time saying to even watch out for meat tenderizers...it made me afraid to eat burgers or meats....I eat out a lot and was always worried that I'd eat something that would make me have a bad reaction...got to go...need some sleep! Take care Ace!
Posted by Caleb462 on May 28, 2003, at 0:41:59
In reply to Ace,Need some help....really appreciate an answer!, posted by McPac on May 27, 2003, at 23:01:26
> Ace, GREAT to hear that your Nardil is working so well for you!
> I've been searching the 'net and it looks like Remeron indirectly acts as a partial agonist at the 5HT1a receptor site. So that should be pretty good for me (that should lessen anxiety). The ssri's have the opposite effect at that site; by raising serotonin at all sites, they increase or further activate that site (making some people feel worse anxiety/anger). I'm so glad that the Nardil is working so good for you Ace---if I were you I'd stay on it for life! I did briefly take Nardil many years ago and it worked VERY GOOD for me too....but I was always so afraid of eating anything...I was afraid I'd eat something that would cause problems....I remember my doctor at the time saying to even watch out for meat tenderizers...it made me afraid to eat burgers or meats....I eat out a lot and was always worried that I'd eat something that would make me have a bad reaction...got to go...need some sleep! Take care Ace!From my understanding... Remeron, by antagonizing alpha-2 receptors, increases serotonin release. And since Remeron blocks both 5-HT2 and 5-HT3 receptors, much of that serotonin gets directed to the 5-HT1a site. So, yeah, an indirect agonist of sorts.
The serotonin receptors are mighty confusing - particularly since some forms (like 5-HT1a, I THINK), appear both pre-synaptically and post-synaptically, and can have different actions depending on this (again, I THINK). I think the 5-HT2c receptor is really the only receptor I have a definite grasp on.
I love pharmacology, and am probably going to go into the field as my career - but I'm only beginning to understand it, can be very complex stuff.
Posted by ace on May 28, 2003, at 1:59:02
In reply to Ace,Need some help....really appreciate an answer!, posted by McPac on May 27, 2003, at 23:01:26
I'm so glad that the Nardil is working so good for you Ace---if I were you I'd stay on it for life!
That is definately the plan! If it takes a few years off my life due to organ damage...oh well..too bad. I prefer physical pain to the misery of my mental pain (I'm not a cutter but).
It's quality not quantity of life too.
I did briefly take Nardil many years ago and it worked VERY GOOD for me too....but I was always so afraid of eating anything...I was afraid I'd eat something that would cause problems....I remember my doctor at the time saying to even watch out for meat tenderizers...it made me afraid to eat burgers or meats....I eat out a lot and was always worried that I'd eat something that would make me have a bad reaction...got to go...need some sleep! Take care Ace!From personal experience I don't even notice the restrictions...they bother me not one bit. But I don't eat out hardly at all. The diet is overrated seriously!
Dude, if there ever is a time you want to change consider it...it is majic!!!!!
Stay happy my brother,
Ace.
Posted by McPac on May 28, 2003, at 16:07:06
In reply to Re: Ace,Need some help....really appreciate an answer!, posted by Caleb462 on May 28, 2003, at 0:41:59
Thanks for the info Caleb!
The serotonin receptors are mighty confusing
>>>>>>Yes....this stuff really drives me bonkers some times, it can get VERY confusing, lol
- particularly since some forms (like 5-HT1a, I THINK), appear both pre-synaptically and post-synaptically,
>>>>>>>>Yes! I remember reading that last night.
and can have different actions depending on this (again, I THINK). I think the 5-HT2c receptor is really the only receptor I have a definite grasp on.
>>>>>>>>>>I don't have a grasp on any receptors, lol
I love pharmacology, and am probably going to go into the field as my career - but I'm only beginning to understand it, can be very complex stuff.
>>>>>>Good luck to you...best wishes!
Posted by McPac on May 28, 2003, at 16:13:16
In reply to Re: Ace,Need some help....really appreciate an answer! » McPac, posted by ace on May 28, 2003, at 1:59:02
"The Undisputed Nardil Champion of the World"!
Anxiety, depression and derealization had you reeling and against the ropes..........but......
a few doses of that powerful and magical MAOI once again has you standing at the top of the mountain......so glad to see you happy again Ace! Stay well my fearless OCD brother!
Posted by ace on May 29, 2003, at 21:42:54
In reply to Ace, you have your Title back!, posted by McPac on May 28, 2003, at 16:13:16
> "The Undisputed Nardil Champion of the World"!
>
> Anxiety, depression and derealization had you reeling and against the ropes..........but......
> a few doses of that powerful and magical MAOI once again has you standing at the top of the mountain......so glad to see you happy again Ace! Stay well my fearless OCD brother!Thanks mate! BTW, you forgot the 'Heavyweight' part in my Title! How dare you!!!
Also bro, the anti-OCD effect has been remarkable - at 60mg! This carbon compound is a miracle of psychopharmacology!
Stay well legend...oh, by the way did you get enough info on Remeron?
Ace
The Undisputed Nardil Heavyweight Champion of the Universe!
Posted by McPac on May 29, 2003, at 22:29:39
In reply to Re: Ace, you have your Title back! » McPac, posted by ace on May 29, 2003, at 21:42:54
Stay well legend...oh, by the way did you get enough info on Remeron?
>>>>>>Yes, thanks, so far so good!
Ace
The Undisputed Nardil Heavyweight Champion of the Universe!>>>>>>>>Ace, I can tell from your posts that not only are you a great, caring person but you are TOO COOL! You and Nardil make the perfect couple---it's a match made in Heaven!!
Posted by McPac on May 29, 2003, at 22:35:08
In reply to Re: Ace, you have your Title back! » McPac, posted by ace on May 29, 2003, at 21:42:54
"The Undisputed Nardil Heavyweight Champion of the Universe"
Lennox Lewis heard about your Heavyweight title and wants you in the ring........
I think you can take him!
Posted by ace on May 30, 2003, at 2:28:43
In reply to Ace....Lennox Lewis wants a piece of you......, posted by McPac on May 29, 2003, at 22:35:08
This is the end of the thread.
Psycho-Babble Medication | Extras | FAQ
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.org
Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.