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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by ace on May 11, 2003, at 21:03:11
Saturday night at around 7.30 pm. first dose 25mg.
2 hours later my derealization was terrible. My sight was hazy, I was sweating and very scared. To exclude the possibility of a serotonin syndrome I called an ambulance. At hospital It was clear to me that it was just an anxiety response (I took 4 Valium at 9.30pm when it happened) - I was calm and there was not as many physical symptoms. I left the hospital by myself.
Last night I took 25mg. No probs!! Tonight I up it to 50mg.
Good news, the OCD has become slightly worse since I began it. Two notable OCD authorities (one being Michael Jenike MD) have noted this is uasually always a good indicator for excellant respones.
It hasn't really helped derealization/phobic anxiety yet. Also waiting for it's AD response.
But, then again, I've only been on it 2 days!!
Ace.
Posted by justyourlaugh on May 11, 2003, at 22:29:37
In reply to Anafranil begun! The good and bad...., posted by ace on May 11, 2003, at 21:03:11
oh ace,,sorry you had to go through that "er "
horror...
i amnot having any luck with zoloft....
i cant function in the odd time with family unless i am drunk....
i am not stupid,,but i shake so bad around them,,,
i dont ever want to go back
i know you will get through..
you are so strong
Posted by freedom2001 on May 12, 2003, at 23:19:13
In reply to Anafranil begun! The good and bad...., posted by ace on May 11, 2003, at 21:03:11
> Saturday night at around 7.30 pm. first dose 25mg.
>
> 2 hours later my derealization was terrible. My sight was hazy, I was sweating and very scared. To exclude the possibility of a serotonin syndrome I called an ambulance. At hospital It was clear to me that it was just an anxiety response (I took 4 Valium at 9.30pm when it happened) - I was calm and there was not as many physical symptoms. I left the hospital by myself.
>
> Last night I took 25mg. No probs!! Tonight I up it to 50mg.
>
> Good news, the OCD has become slightly worse since I began it. Two notable OCD authorities (one being Michael Jenike MD) have noted this is uasually always a good indicator for excellant respones.Ace, why does the OCD has to get worse to become a good indicator for excellent responses??????
>
> It hasn't really helped derealization/phobic anxiety yet. Also waiting for it's AD response.
>
> But, then again, I've only been on it 2 days!!
>
>
> Ace.
Posted by ace on May 13, 2003, at 2:23:09
In reply to Re: Anafranil begun! The good and bad.... » ace, posted by freedom2001 on May 12, 2003, at 23:19:13
Posted by freedom2001 on May 13, 2003, at 4:41:47
In reply to I have no idea! (nm) » freedom2001, posted by ace on May 13, 2003, at 2:23:09
Hi
but why do u say that two notable authorities one being michael jenike MD has noted this.Can you show me any links or documentation on OCD being worse being good indicator of excellent response?
Coz i'm interested.
Thanks.
Freedom.
Posted by Questionmark on May 14, 2003, at 1:23:14
In reply to Re: Anafranil begun! The good and bad.... » ace, posted by freedom2001 on May 12, 2003, at 23:19:13
>"why does the OCD has to get worse to become a good indicator for excellent responses??????"
i think it's because of the stimulation of 5-HT (serotonin) autoreceptors that occurs early on (bcz of that extra serotonin floating around from the reuptake inhibition), which results in decreased 5-HT release. Eventually (within about a month) the autoreceptors downregulate and there is an increase in 5-HT release. . That's how i understand it anyway; i could be wrong.
i guess we're lucky that the autoreceptors apparently downregulate so much faster than the postsynaptic receptors-- otherwise SRIs wouldn't work, right? Weird.
This is the end of the thread.
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