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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 11 of 11. This is the beginning of the thread.
Posted by rod on April 11, 2002, at 7:29:38
Hi all there,
I am currently starting to take part in the study of a novle antidepressant MK-869.Has anyone first experineces with it (relating depression)? Anyone else taking part in it?
bye
Posted by Ritch on April 11, 2002, at 10:53:26
In reply to Neurokinin Substance P Antagonist MK-869 Study, posted by rod on April 11, 2002, at 7:29:38
> Hi all there,
>
> I am currently starting to take part in the study of a novle antidepressant MK-869.Has anyone first experineces with it (relating depression)? Anyone else taking part in it?
>
> byeRod,
I doubt if you will find many who are also in the study that will post here, however, if you would tell us about what is going on (how you are feeling, etc.) that would be really cool. There are many here who are watching the development of alternative antidepressants, etc.
MItch
Posted by johnj on April 11, 2002, at 11:44:26
In reply to Neurokinin Substance P Antagonist MK-869 Study, posted by rod on April 11, 2002, at 7:29:38
I have not heard of anyone else here, but I would love to hear how it goes. There are a lot of people here, including me, that follow new meds and studies. Thanks for posting. John
Posted by Anna Laura on April 11, 2002, at 23:23:51
In reply to Neurokinin Substance P Antagonist MK-869 Study, posted by rod on April 11, 2002, at 7:29:38
> Hi all there,
>
> I am currently starting to take part in the study of a novle antidepressant MK-869.Has anyone first experineces with it (relating depression)? Anyone else taking part in it?
>
> bye
Good to know! Keep us updated!Wishing you the best
Posted by IsoM on April 12, 2002, at 0:01:40
In reply to Neurokinin Substance P Antagonist MK-869 Study, posted by rod on April 11, 2002, at 7:29:38
Rod,
1. Is this a double-blind study, or do you know for a certainty that you're receiving the new antidepressant?
2. Can you tell us what research lab/university is conducting this study?
3. How long will this study last for you & how many others are included in the study?
4. Have you got a web link for us to check on its progress?Sorry for all the questions but I'm real curious.
Posted by rod on April 12, 2002, at 2:51:54
In reply to Your Role in the Study » rod, posted by IsoM on April 12, 2002, at 0:01:40
> Rod,
> 1. Is this a double-blind study, or do you know for a certainty that you're receiving the new antidepressant?double blind compare study to paroxetine.
MK-869 80mg 33%
MK-869 160mg 33%
MK-869 240mg 16.6%
Paroxetine 16.6%I dont know what I will be getting. I am currently in wash out phase of my last medication, cloimipramine. I will recieve the med (unprinted bottle of pills) on thursday the 16.4.02
> 2. Can you tell us what research lab/university is conducting this study?
Europe/ Austria / Vienna
University Clinic for Psychiatry> 3. How long will this study last for you & how many others are included in the study?
If I stick to it, it will go on for 13 months.
900 persons world wide.> 4. Have you got a web link for us to check on its progress?
No, sorry. As for Europe in gerneral, you dont get acces to any information regarding medications wich is intended for medical professoionals only.
>
> Sorry for all the questions but I'm real curious.
Posted by denise528 on August 2, 2002, at 6:43:35
In reply to Neurokinin Substance P Antagonist MK-869 Study, posted by rod on April 11, 2002, at 7:29:38
> Hi all there,
>
> I am currently starting to take part in the study of a novle antidepressant MK-869.Has anyone first experineces with it (relating depression)? Anyone else taking part in it?
>
> byeRich,
Are you still about? Do you have any updates on your experience with this Substance P Antagonist?
Denise
Posted by Ritch on August 2, 2002, at 9:52:38
In reply to Re: Neurokinin Substance P Antagonist MK-869 Study, posted by denise528 on August 2, 2002, at 6:43:35
> > Hi all there,
> >
> > I am currently starting to take part in the study of a novle antidepressant MK-869.Has anyone first experineces with it (relating depression)? Anyone else taking part in it?
> >
> > bye
>
> Rich,
>
> Are you still about? Do you have any updates on your experience with this Substance P Antagonist?
>
> DeniseDenise,
Rod was the one in the study. Maybe he will read this and give us some kind of update?
Posted by rod on August 2, 2002, at 12:24:12
In reply to Re: Neurokinin Substance P Antagonist MK-869 Study, posted by denise528 on August 2, 2002, at 6:43:35
> Are you still about? Do you have any updates on your experience with this Substance P Antagonist?
>
> DeniseSorry for not informing you, but I did quit after one day.
How it started:
Quitted Cloimipramine 75 mg to 0 mg. This made me very uncomfortable and caused great dizzyness, and other symptoms of withdrawal.
I got 3 bottles of pills.
2 of them labeled MK-869 and 1 paroxetine. Had to take 1 of each bottle. One (or two) of these bottles contained placebos. So i looked up in the internet how paroxetine tbblets look like, and yes they had the shape of real ones, but somehow they looked "like pressed pills of flour with big corn size". And they tasted like tasteless flour (crunched the tablet with my teeth). I opened the capsules of MK-869, it had a mild taste of soap.
So I really thought I have "the real ones", because I expected the paroxetine to taste "organic chemistry bitter".
So i started taking it, but felt very bad because i did quit my Cloimipramine very quick.
And after a few hours I began to fell slightly more relaxed, but this may only be the placebo effect. Went to bed, and then had this horrible experience. Like waking up, getting back to consciousness, but not able to move a lousy finger, being paralyzed. And then I got ahorrible panic attack, wanted to scream out for my mother to help me, but was not able to open my mouth. I was really frightened to death. But somehow it went away and felt to sleep again. Maybe this was "just" a nightmare, but the next morning I was very scared and the dizziness I had form quiting cloimipramine got heavier. So i called the doctor conducting the study, and told him about all, and he answerd "Okay, i will inform Merck about it." That was all he had to tell me, and i felt like a little test rat!
This was just a very bad start, and I didnt want to take part in this study any more. Just had a bad feeling about this, and I had little nausea, maybe a sign for paroxetine, because MK-869 is an "anti nausea" drug for cancer patients with chemo therapy too. And maybe this nightly experience was a panic attack (not unlikely for paroxetine).So I went back to common drugs, and for whom interested, found a mixture that changed my life. This is also the reason I didnt told you about quitting, because I really feel better now and "dont spend all the time in fromt of my computer performing some drug research", or whatever you call it. I am just working on getting my life back to how I want it to be.
My mixture I found for myself:
100 mg Amitryptiline at night (extended release form)
100 mg Effexor (immediate release)
Vitamin B combi (300 mg B1, 600mg B6, 600ug B12), yes this one is really high, but I this is a "med" intended for people having a damaged nerve system caused by injuries or equal (That is what is written on the prescription info leaf). This one really helps, and I really feel bad when I do not take them.
And finally 4-8g of omega 3 fatty acids (1g containig 280mg EPA, 190 mg DHA)Each of them did some good the first time I took them, and the real benefits showed up later.
So, good luck folks, in finding the right med for you! hope mine last
bye
Posted by BarbaraCat on August 5, 2002, at 12:56:33
In reply to Neurokinin Substance P Antagonist MK-869 Study, posted by rod on April 11, 2002, at 7:29:38
Pleeeeeze keep us posted. I have fibromyalgia which is suspected to be a too high substance P condition. Looking forward to any and all feedback. Best of luck with your trial.
> Hi all there,
>
> I am currently starting to take part in the study of a novle antidepressant MK-869.Has anyone first experineces with it (relating depression)? Anyone else taking part in it?
>
> bye
Posted by BarbaraCat on August 5, 2002, at 13:04:42
In reply to Re: Neurokinin Substance P Antagonist MK-869 Study, posted by rod on August 2, 2002, at 12:24:12
Sorry, didn't see your previous post. I'm glad you found a helpful combo. I take 12 g fish oil and found that it helps alot. Thanks for you vit B feedback. I've never tried that high a dosage, but my nervous system is very definitely damaged. I'll give it a short trial.
And last, I commend you on your sleuthing skills with the pills. Double blind studies do seem pretty heartless for the 'lab rats'.
This is the end of the thread.
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