Posted by rod on August 2, 2002, at 12:24:12
In reply to Re: Neurokinin Substance P Antagonist MK-869 Study, posted by denise528 on August 2, 2002, at 6:43:35
> Are you still about? Do you have any updates on your experience with this Substance P Antagonist?
>
> DeniseSorry for not informing you, but I did quit after one day.
How it started:
Quitted Cloimipramine 75 mg to 0 mg. This made me very uncomfortable and caused great dizzyness, and other symptoms of withdrawal.
I got 3 bottles of pills.
2 of them labeled MK-869 and 1 paroxetine. Had to take 1 of each bottle. One (or two) of these bottles contained placebos. So i looked up in the internet how paroxetine tbblets look like, and yes they had the shape of real ones, but somehow they looked "like pressed pills of flour with big corn size". And they tasted like tasteless flour (crunched the tablet with my teeth). I opened the capsules of MK-869, it had a mild taste of soap.
So I really thought I have "the real ones", because I expected the paroxetine to taste "organic chemistry bitter".
So i started taking it, but felt very bad because i did quit my Cloimipramine very quick.
And after a few hours I began to fell slightly more relaxed, but this may only be the placebo effect. Went to bed, and then had this horrible experience. Like waking up, getting back to consciousness, but not able to move a lousy finger, being paralyzed. And then I got ahorrible panic attack, wanted to scream out for my mother to help me, but was not able to open my mouth. I was really frightened to death. But somehow it went away and felt to sleep again. Maybe this was "just" a nightmare, but the next morning I was very scared and the dizziness I had form quiting cloimipramine got heavier. So i called the doctor conducting the study, and told him about all, and he answerd "Okay, i will inform Merck about it." That was all he had to tell me, and i felt like a little test rat!
This was just a very bad start, and I didnt want to take part in this study any more. Just had a bad feeling about this, and I had little nausea, maybe a sign for paroxetine, because MK-869 is an "anti nausea" drug for cancer patients with chemo therapy too. And maybe this nightly experience was a panic attack (not unlikely for paroxetine).So I went back to common drugs, and for whom interested, found a mixture that changed my life. This is also the reason I didnt told you about quitting, because I really feel better now and "dont spend all the time in fromt of my computer performing some drug research", or whatever you call it. I am just working on getting my life back to how I want it to be.
My mixture I found for myself:
100 mg Amitryptiline at night (extended release form)
100 mg Effexor (immediate release)
Vitamin B combi (300 mg B1, 600mg B6, 600ug B12), yes this one is really high, but I this is a "med" intended for people having a damaged nerve system caused by injuries or equal (That is what is written on the prescription info leaf). This one really helps, and I really feel bad when I do not take them.
And finally 4-8g of omega 3 fatty acids (1g containig 280mg EPA, 190 mg DHA)Each of them did some good the first time I took them, and the real benefits showed up later.
So, good luck folks, in finding the right med for you! hope mine last
bye
poster:rod
thread:102731
URL: http://www.dr-bob.org/babble/20020731/msgs/114947.html