![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 8 of 8. This is the beginning of the thread.
Posted by JohnX2 on December 3, 2001, at 18:00:33
Anyone know of crf anatagonists in the pipeline?
It would be fun to enter a clinical trial
(but not be on placebo).-john
Posted by IsoM on December 3, 2001, at 19:32:18
In reply to crf antagonists in the pipeline?, posted by JohnX2 on December 3, 2001, at 18:00:33
As far as anything I've read, CRF antagonists are just really being tested on rats still. There was a study done in Munich, Germany on a few people but not enough to be conclusive.
Here's an e-mail address of a person from the The Salk Institute for Biological Studies which is doing research on it right now. It says to direct any inquiries to her. amueller@salk.edu
Anne-Marie Mueller
Technology Transfer Associate
The Salk Institute
P.O. Box 85800
San Diego, CA 92186-5800
Telephone Number: (858) 453-4100 ext. 1275
Fax Number: (858) 450-0509
> Anyone know of crf anatagonists in the pipeline?
> It would be fun to enter a clinical trial
> (but not be on placebo).
>
> -john
Posted by bob on December 3, 2001, at 22:52:18
In reply to Re: crf antagonists in the pipeline? » JohnX2, posted by IsoM on December 3, 2001, at 19:32:18
What is "crf"?
Posted by IsoM on December 3, 2001, at 23:07:33
In reply to Re: crf antagonists in the pipeline?, posted by bob on December 3, 2001, at 22:52:18
crf is the acronym for corticotropin-releasing factor. It's a peptide hormone produced by the hypothalamus in response to stress. The following site gives a bit more info on it:
http://www.biopsychiatry.com/crfdep.htm> What is "crf"?
Posted by bob on December 3, 2001, at 23:19:32
In reply to Re: crf antagonists in the pipeline? » bob, posted by IsoM on December 3, 2001, at 23:07:33
Posted by Cam W. on December 4, 2001, at 0:22:54
In reply to crf antagonists in the pipeline?, posted by JohnX2 on December 3, 2001, at 18:00:33
John - None of the crf antagonists have panned out. The one's tested so far only work short term. If they will be of any use at all, the may be used to kcik start antidepressants (ie. give a fater onset of action). Dr.F.Holsboer has a couple studies out in the past couple years explaining why they don't work longer than 2 weeks, but I can't remember the reasoning. All I remember is that the one's that have been tested probably won't be marketed as antidepressants. - Cam
Posted by SLS on December 4, 2001, at 7:41:42
In reply to Re: crf antagonists in the pipeline? » JohnX2, posted by Cam W. on December 4, 2001, at 0:22:54
> John - None of the crf antagonists have panned out. The one's tested so far only work short term. If they will be of any use at all, the may be used to kcik start antidepressants (ie. give a fater onset of action). Dr.F.Holsboer has a couple studies out in the past couple years explaining why they don't work longer than 2 weeks, but I can't remember the reasoning. All I remember is that the one's that have been tested probably won't be marketed as antidepressants. - Cam
Hi Cam.That's ashame. I am always hopeful that drugs with mechanisms of action completely different from currently available antidepressants will be discovered. I guess one can think of the monoamine reuptake inhibitors as "me too" drugs. It seems that many people just don't respond to this strategy. Since I am one of those who don't, I get excited when something novel appears.
Re: CRH (formally called CRF) and cortisol.
How thoroughly have you investigated the possible efficacy of ketaconozole in treating depression? Has it ever been used as an adjunct?
- Scott
Posted by Cam W. on December 4, 2001, at 8:19:49
In reply to Re: CRH (crf) antagonists in the pipeline? » Cam W., posted by SLS on December 4, 2001, at 7:41:42
Scott - I haven't directly investigated ketoconazole for depression (too many side effects), but some of the side literature comments (ie. comments made in, and basically general asides in, related "overall Tx of depression" articles) have made me raise an eyebrow.
I really have not read anything that would make me believe that the main mechanism of action of ketoconazole was not really due to cytochrome enzyme induction (perhaps increasing the concentration an unnamed endogenous/exogenous protein/enzyme/molecule relevant to depressive symptomatology). I have thought a fair bit about what the cytochrome system does within the body. We always are hearing about what foreign, man-made chemicals it metabolizes, but never about what it really was designed for. Surely, the CYP system is not a recent evolved system to metabolize Elavil and Prozac; it has to have some homeostatic purpose; possibly metabolizing some environmental compound (eg. dietary constituent?), perhaps relating to mood.
Hmmmm....Cam
This is the end of the thread.
Psycho-Babble Medication | Extras | FAQ
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.org
Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.