Posted by SLS on December 4, 2001, at 7:41:42
In reply to Re: crf antagonists in the pipeline? » JohnX2, posted by Cam W. on December 4, 2001, at 0:22:54
> John - None of the crf antagonists have panned out. The one's tested so far only work short term. If they will be of any use at all, the may be used to kcik start antidepressants (ie. give a fater onset of action). Dr.F.Holsboer has a couple studies out in the past couple years explaining why they don't work longer than 2 weeks, but I can't remember the reasoning. All I remember is that the one's that have been tested probably won't be marketed as antidepressants. - Cam
Hi Cam.That's ashame. I am always hopeful that drugs with mechanisms of action completely different from currently available antidepressants will be discovered. I guess one can think of the monoamine reuptake inhibitors as "me too" drugs. It seems that many people just don't respond to this strategy. Since I am one of those who don't, I get excited when something novel appears.
Re: CRH (formally called CRF) and cortisol.
How thoroughly have you investigated the possible efficacy of ketaconozole in treating depression? Has it ever been used as an adjunct?
- Scott
poster:SLS
thread:85895
URL: http://www.dr-bob.org/babble/20011202/msgs/85951.html