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Dr. Bob is Robert Hsiung, MD,
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Posted by Margit on August 31, 2001, at 20:01:37
I was wondering if Amisulpride helps with the above? Zyprexa which I am currently on seems to do that. My problem with it though is sedation and acid reflux. So, I thought I give Amisulpride a try and have better luck in regard to side efeects. But I would like it to help for depression and anxiety. Anybody know.
Thanks for any responses.
Margit
Posted by SalArmy4me on August 31, 2001, at 20:16:33
In reply to Does Amisulpride help with depression, anxiety?, posted by Margit on August 31, 2001, at 20:01:37
Its worth a try. Order it from Farmacia Cerati: http://www.farmaciacerati.it/
Smeraldi E. Amisulpride versus fluoxetine in patients with dysthymia or major depression in partial remission: a double-blind, comparative study. J Affect Disord. 1998;48:47-56:
"In a multicentre, double blind, parallel group study 281 patients with DSM III-R diagnosis of dysthymia or a single episode of major depression in partial remission were randomised to 3 months of treatment with amisulpride 50 mg/day or fluoxetine 20 mg/day. The baseline Montgomery and Asberg Depression Rating Scale (MADRS) total score was reduced by at least 50% in 74.1% of patients (103/139) with amisulpride and 67.4% (87/129) with fluoxetine (P =0.230). No significant differences between treatment groups were found in the reductions in mean total score with the MADRS, Widlocher psychomotor retardation scale, Sheehan disability scale, and CGI. Anxiety measured by HAM-A total mean score decreased significantly more with amisulpride (63%) than with fluoxetine (54%; P = 0.021). There were 13 dropouts due to adverse events with amisulpride and ten with fluoxetine. The number of patients reporting at least one adverse event was similar in the two groups (amisulpride 47.5%; fluoxetine 40.9%)..."
Rihmer, Zoltan. Dysthymic disorder: implications for diagnosis and treatment. Current Opinion in Psychiatry. 12(1):69-75, January 1999:
"As dysthymic disorder is a chronic condition, it has been pointed out that the patients need full-dose maintenance pharmacotherapy, preferably with new compounds, which are much better tolerated. Amisulpride (an atypical neuroleptic, which in low dose acts as a dopamine enhancer) has also been found to be quite effective in dysthymic disorder..."
Lecrubier Y, Boyer P, Turjanski S, Rein W. Amisulpride Study Group. Amisulpride versus imipramine and placebo in dysthymia and major depression. J Affect Disord 1997; 43:95-103:
"Amisulpride, a selective antagonist of D2 and D3 dopamine receptors, acts preferentially on presynaptic receptors increasing dopaminergic transmission at low doses. In a multicentre, 6 months, placebo-controlled trial, amisulpride (50 mg/daily) was compared to imipramine (100 mg/daily) in the treatment of patients with DSM-III-R criteria for primary dysthymia, dysthymia with major depression or major depression in partial remission. A total of 219 patients were included. Both analyses (intention-to-treat and "per protocol' analysis) detected significant differences between groups (active treatment vs. placebo) on all main rating scales (CGI, MADRS, ERD, and SANS). The number of patients reporting at least one adverse event was higher in the imipramine group than in the two other, mainly due to anticholinergic effects. Endocrine symptoms were more frequent in female patients treated with amisulpride. These results confirm the interest of a drug acting on dopaminergic transmission such as amisulpride in the treatment of depressed patients..."
Posted by JohnL on September 1, 2001, at 5:43:04
In reply to Does Amisulpride help with depression, anxiety?, posted by Margit on August 31, 2001, at 20:01:37
> I was wondering if Amisulpride helps with the above? Zyprexa which I am currently on seems to do that. My problem with it though is sedation and acid reflux. So, I thought I give Amisulpride a try and have better luck in regard to side efeects. But I would like it to help for depression and anxiety. Anybody know.
> Thanks for any responses.
> MargitHi Margit,
Amisulpride is absolutely wonderful for the symptoms you described. I have tried them all, and Amisulpride was my favorite. I am currently on Zyprexa, which is my second favorite of the bunch. I switched merely because Amisulpride did not help me with sleep. I needed help with sleep. Zyprexa is great for my sleep. The two drugs seem to work fairly similar, though I must admit Amisulpride was better.Clinical studies look promising with Amisulpride. It is at least as good, and often better, than antidepressants.
It was a while ago, but one of the regular psychobabblers recorded and studied the results of other psychobabblers who had tried Amisulpride. I don't remember the exact numbers, but it was something like 70% experienced significant improvement. Though those numbers are similar to what can be expected from any drug, the real interesting and encouraging part is that ALL the people who tried Amisulpride were very difficult treatment resistant patients. For one drug to help 70% of the people in a very difficult population is quite amazing, as I see it.
I still take Amisulpride from time to time. Here's why. My current cocktail of Prozac+Adrafinil+Zyprexa does a wonderful job. But, every now and then I experience a sinking spell. When that happens, I take one dose of Amisulpride. It lifts me right back up in about three hours, and then I am fine for weeks.
Amisulpride can work quickly, or it may come on slowly over a period of weeks. But I just wanted to say that if you have responded well to Zyprexa, then you could likely respond well to Amisulpride as well. I respond well to either one. Amisulpride is more stimulative at low doses (25mg to 75mg). Ironically, you could possibly experience increased anxiety at first, which will later disappear on its own. I think the greatest benefit I ever noticed from Amisulpride was the calm and cool relaxed feeling I had in anxious situations. But that didn't happen overnight. It took a few weeks.
Hope this helps.
John
Posted by KarenRB53 on June 26, 2006, at 13:06:27
In reply to Re: Does Amisulpride help with depression, anxiety?, posted by JohnL on September 1, 2001, at 5:43:04
Do you still use the Amulsidpride?
Thanks, Karen
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