Psycho-Babble Medication Thread 63903

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Benzodiazepines/OCD

Posted by PaulB on May 22, 2001, at 12:14:56

It is my understanding that only seroternergic drugs, particularly Clomipramine and certain SSRI's are effective for the anxiety disorder Obsessive Compulsive Disorder and the benzodiazepines are of little use. But for panic disorder, both the benzodiazepines and SSRI'S are effective. I would be interested to hear from people who suffer OCD and their experience with the benzodiazepines for this mental health problem.

 

Re: Benzodiazepines/OCD

Posted by Mr.Scott on May 22, 2001, at 12:30:47

In reply to Benzodiazepines/OCD, posted by PaulB on May 22, 2001, at 12:14:56

My understanding is that Klonopin (a potent anticonvulsant benzodiazepine) has some utility in treating OCD.

 

Re: Benzodiazepines/OCD PaulB

Posted by SalArmy4me on May 22, 2001, at 14:35:56

In reply to Benzodiazepines/OCD, posted by PaulB on May 22, 2001, at 12:14:56

GREIST, JOHN H.. JEFFERSON, JAMES W.. Pharmacotherapy for OCD. British Journal of Psychiatry. 173(35S) Supplement:64-70, August 98:
Because it is usually classified as an anxiety disorder, there would be semantic logic in using an anti-anxiety drug for OCD. A recent review (Hewlett, 1993) summarises positive case reports over many years. Interpretation of these reports is difficult as the distinction between quelling of anxiety and specific anti-OCD effects is not clear, and abnormalities in benzodiazepine receptors have not been identified in people with OCD (Weizman et al, 1993).
The only controlled trial of a benzodiazepine compared clonidine, clonazepam, clomipramine and diphenhydramine (Hewlett et al, 1992). In this six week crossover design, clonazepam was significnatly more effective at three weeks than nay of the other treatments but plateaued thereafter. Clomipramine evinced a numeric but not statistical superiority that was still increasing when the study concluded at six weeks. Diphenhydramine was as effective as clonazepam at six weeks while clonidine was less effective than the other three treatments. Dropouts because of side-effects were greatest for clonazepam. Interestingly, among benzodiazepines, clonazepam may have unique effects upon serotonin (Hwang & Van Woert, 1979; Pranzatelli, 1989).

 

Re: Benzodiazepines/OCD

Posted by PaulB on May 22, 2001, at 17:46:23

In reply to Re: Benzodiazepines/OCD PaulB, posted by SalArmy4me on May 22, 2001, at 14:35:56

> GREIST, JOHN H.. JEFFERSON, JAMES W.. Pharmacotherapy for OCD. British Journal of Psychiatry. 173(35S) Supplement:64-70, August 98:
> Because it is usually classified as an anxiety disorder, there would be semantic logic in using an anti-anxiety drug for OCD. A recent review (Hewlett, 1993) summarises positive case reports over many years. Interpretation of these reports is difficult as the distinction between quelling of anxiety and specific anti-OCD effects is not clear, and abnormalities in benzodiazepine receptors have not been identified in people with OCD (Weizman et al, 1993).
> The only controlled trial of a benzodiazepine compared clonidine, clonazepam, clomipramine and diphenhydramine (Hewlett et al, 1992). In this six week crossover design, clonazepam was significnatly more effective at three weeks than nay of the other treatments but plateaued thereafter. Clomipramine evinced a numeric but not statistical superiority that was still increasing when the study concluded at six weeks. Diphenhydramine was as effective as clonazepam at six weeks while clonidine was less effective than the other three treatments. Dropouts because of side-effects were greatest for clonazepam. Interestingly, among benzodiazepines, clonazepam may have unique effects upon serotonin (Hwang & Van Woert, 1979; Pranzatelli, 1989).

There does seem to be talk here of Clonazepam, as having some utility for OCD sufferers but not because of its classical tranquillising properties but because of the fact that a metabolite of Clonazepam is a serotonin agonist. Im not going to go look up its name. For the first few weeks a benzodiazepine seems to be a cure for all that ails thee, so claimed Roche in the early 60s but I dont think they help OCD sufferers much. Any more views on GABA/OCD welcomed?

 

Re: Benzodiazepines/OCD

Posted by rogdog on May 22, 2001, at 18:32:43

In reply to Benzodiazepines/OCD, posted by PaulB on May 22, 2001, at 12:14:56

PAUL, I HAVE HAD PRETTY GOOD SUCCESS WITH XANAX FOR OCD, I DOKNT KNOW ABOUT YOUR SCENARIO, BUT IT SEEMS THAT THERE ARE SOME INIVIDUALS WHO RESPOND TO BENZO'S AND NOTHING ELSE. I TAKE 2X50MGS ULTRAM AND 4 MGS OF XANAX THROUGH OUT THE DAY AND IT SEEMS TO WORK WELL, HOPE THIS IS OF SOME HELP... GOD BLESS, ROGDOG


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