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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 8 of 8. This is the beginning of the thread.
Posted by buffalo1 on January 17, 2001, at 16:20:47
Does anyone know if there are any new meds due out soon, specificlly, AD. I know that Phifzer has Zoldox coming out, but that's a neuroleptic.
Posted by JohnL on January 17, 2001, at 17:45:45
In reply to Any new meds in the pipeline? , posted by buffalo1 on January 17, 2001, at 16:20:47
> Does anyone know if there are any new meds due out soon, specificlly, AD. I know that Phifzer has Zoldox coming out, but that's a neuroleptic.
I'm not familiar with what's in the pipeline. I know a company called Sepracor is constantly working on creating new versions of existing drugs, except without the side effects.
Of course, it depends on what country you're talking about. New drugs for the USA? I can tell you for sure there are wonderful meds throughout the world that will never be subjected to the 15 years and 15 million dollars it takes to get through the overstuffed suits of the FDA. The cool part though is that we don't need to wait for the FDA's approval. Millions of people over decades have already proven the medicines' worth and safety. It's simply a matter of getting them from there to here, which is easy with a computer, a credit card, and a mailbox. :-)
John
Posted by kazoo on January 18, 2001, at 0:56:15
In reply to Re: Any new meds in the pipeline? , posted by JohnL on January 17, 2001, at 17:45:45
> ...15 million dollars it takes to get through the overstuffed suits of the FDA.
^^^^^^^^^^
Fifteen million clams? A mere bag of shells, Sir! The fact is that it takes approximately $250 million bucks to get a new drug to market. Check out the fiasco Knoll Pharmaceuticals went through with MERIDIA, developed first as an SSRI, but later changed to an anorectic agent (diet pill) when it failed all sorts of studies and tests. A double whammy, and waste, in this caseYou're probably thinking of the usual 15 million dollar yearly bonuses these drug CEOs so casually pocket, without remorse or compunction. Oink! Oink!
Greetz to John: your message was excellent.
kazoo
Posted by MarkinBoston on January 18, 2001, at 18:11:11
In reply to Any new meds in the pipeline? , posted by buffalo1 on January 17, 2001, at 16:20:47
> Does anyone know if there are any new meds due out soon, specificlly, AD. I know that Phifzer has Zoldox coming out, but that's a neuroleptic.
There was an article this week in the Boston Globe about Pfizer and drugs in the pipeline. They said two were going to Phase III trials later this year and no sexual dysfunction was one quality remarked upon in the chart.
From a press release on their web site about drugs in the pipeline:
http://www.pfizer.com/pfizerinc/investing/analystrelease1211.html...and Pagoclone, a novel Gaba A receptor modulator for the treatment of panic disorders.
He also reported that Pfizer is investigating four mechanistically distinct antidepressants in early stages of development, and is beginning Phase III trials in 2001 for CP-122,721, an NK-1 antagonist. This compound demonstrated robust antidepressive effects in a Phase II trial in depressed patients.
Phase II trials are ongoing for CP-526,555, an oral treatment for smoking cessation. Smoking causes 400,000 deaths a year and generates annual healthcare system costs of $50 billion each year. As a partial agonist, CP-526,555 partially stimulates the nicotine receptor in the brain to satisfy a smoker's nicotine craving while, at the same time, blocking the nicotine receptor from the reinforcing value of nicotine in smoke.
Posted by roo on January 19, 2001, at 9:16:28
In reply to Re: Any new meds in the pipeline? » buffalo1, posted by MarkinBoston on January 18, 2001, at 18:11:11
Hey JohnL
Is it really that easy ordering drugs from
overseas? Don't you have to have a prescription?
Do you have to pay full price or does health insurance
work?
Posted by kazoo on January 19, 2001, at 11:30:48
In reply to Any new meds in the pipeline? , posted by buffalo1 on January 17, 2001, at 16:20:47
> Does anyone know if there are any new meds due out soon ...
^^^^^^^^
Here's a brief list dated 12/2000
Medications with New Drug Applications submitted to FDA:
ENA-713 (Exelon)
Metrifonate
Physostigmine LA (Synapton)
Medications in Phase III trials:
Idebenone
Linopirdine
AF 102B
Propentofylline
Galanthamine (Reminyl [TM])
ALCAR
Eptastigmine
Medications in Phase II trials:
Xanomeline Skin Patch
AIT-082 (NeoTrofin)
But on the other hand:
Medications Discontinued:
Milameline
Xanomeline Oral Formula
ABT-418
SB 202026 (Memric)
Suritozole
Besipirdine
Sabeluzole
Velnacrine
Oxiracetam
LU 25-109
Posted by Andre Allard on January 20, 2001, at 20:32:01
In reply to Any new meds in the pipeline? , posted by buffalo1 on January 17, 2001, at 16:20:47
go to http://www.nami.org for info on pipline drugs.
Supposidly they are something like 18 ADs and 13 atypical antipsychotics in trials.
Posted by ChrisK on January 21, 2001, at 6:39:16
In reply to Any new meds in the pipeline? , posted by buffalo1 on January 17, 2001, at 16:20:47
From another BBS is a link:
http://www.phrma.org/searchcures/newmeds/mentalillsurv2000/mental00.pdf
Lots of information but most of the "new" drugs are either "me too" types or getting off label usage approved.
> Does anyone know if there are any new meds due out soon, specificlly, AD. I know that Phifzer has Zoldox coming out, but that's a neuroleptic.
This is the end of the thread.
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