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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 3 of 3. This is the beginning of the thread.
Posted by jen on December 2, 1999, at 17:06:19
i have a question. i have been in the hospital 3 times now
for what they say is sertonin syndrome. the first i was
on the following meds:celexa,remeron,depakote,and neurontin
when i got out they took me off those meds. i had a period of
a 3 week washout. then i was put on valium,neurontin,and parnate
i did fine and then seroquel was added. i then developed
sertonin syndrome again. i went back to the hospital.
they then took me off seroquel and lowered the doses of
my other meds. they then increased my parnate to 50mg
once a day and increased my valium to 30mg. a day which
i was fine for another month. then they added seroquel
again and within 2 weeks i was back in the hospital. my
question is could the seroquel be causing the sertonin
syndrome?
Posted by Adam on December 2, 1999, at 20:15:29
In reply to sertonin syndrome, posted by jen on December 2, 1999, at 17:06:19
Serotonin binds to a large family of receptors on neurons. They are referred to
collectively as 5-HT receptors, and are usually denoted by a number (x) meaning a
major subtype, and a letter (n) denoting an isoform within that subclass. So you
often see 5-HT receptors referred to in this form: 5-HTxn, ex. 5-HT1A.Seroquel (quetiaprine) is a potent 5-HT1A agonist and also a 5-HT2A/2C antagonist.
Stimulation of 5-HT1A might be a problem if you are experiencing serotonin syndrome,
so, yes, I think seroquel administration could perhaps contribute to serotonin
syndrome.> i have a question. i have been in the hospital 3 times now
> for what they say is sertonin syndrome. the first i was
> on the following meds:celexa,remeron,depakote,and neurontin
> when i got out they took me off those meds. i had a period of
> a 3 week washout. then i was put on valium,neurontin,and parnate
> i did fine and then seroquel was added. i then developed
> sertonin syndrome again. i went back to the hospital.
> they then took me off seroquel and lowered the doses of
> my other meds. they then increased my parnate to 50mg
> once a day and increased my valium to 30mg. a day which
> i was fine for another month. then they added seroquel
> again and within 2 weeks i was back in the hospital. my
> question is could the seroquel be causing the sertonin
> syndrome?
Posted by Elizabeth on December 2, 1999, at 20:38:02
In reply to Re: sertonin syndrome, posted by Adam on December 2, 1999, at 20:15:29
Jen,
As Adam says, it's plausible for either of those combinations to cause then serotonin syndrome. Your sensitivity probably has to do with your particular serotonin receptor characteristics.
Out of curiosity, what symptoms did you have these three times? (I've been diagnosed with serotonin syndrome before as well so I'm interested to compare notes.)
This is the end of the thread.
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