Posted by Adam on December 2, 1999, at 20:15:29
In reply to sertonin syndrome, posted by jen on December 2, 1999, at 17:06:19
Serotonin binds to a large family of receptors on neurons. They are referred to
collectively as 5-HT receptors, and are usually denoted by a number (x) meaning a
major subtype, and a letter (n) denoting an isoform within that subclass. So you
often see 5-HT receptors referred to in this form: 5-HTxn, ex. 5-HT1A.Seroquel (quetiaprine) is a potent 5-HT1A agonist and also a 5-HT2A/2C antagonist.
Stimulation of 5-HT1A might be a problem if you are experiencing serotonin syndrome,
so, yes, I think seroquel administration could perhaps contribute to serotonin
syndrome.> i have a question. i have been in the hospital 3 times now
> for what they say is sertonin syndrome. the first i was
> on the following meds:celexa,remeron,depakote,and neurontin
> when i got out they took me off those meds. i had a period of
> a 3 week washout. then i was put on valium,neurontin,and parnate
> i did fine and then seroquel was added. i then developed
> sertonin syndrome again. i went back to the hospital.
> they then took me off seroquel and lowered the doses of
> my other meds. they then increased my parnate to 50mg
> once a day and increased my valium to 30mg. a day which
> i was fine for another month. then they added seroquel
> again and within 2 weeks i was back in the hospital. my
> question is could the seroquel be causing the sertonin
> syndrome?
poster:Adam
thread:16093
URL: http://www.dr-bob.org/babble/19991123/msgs/16099.html