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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by B2chica on June 7, 2011, at 11:00:05
i just sat in on a lecture that was discussing this effect in mice. and would like to know a little more about it in the psychopharmacology aspect.
the discussion was about auditory function and development in mice
it was mentioned that the amount of Acetycholine effects the amount of calcium channel which i guess are an agonist of the slow potassium channels?i was trying to grasp both what he was saying applying to auditory function and both in my mind trying to alter that to psych meds and didnt do either one well...please assist.
how one effects the other?
thanks
b2c.
Posted by B2chica on June 8, 2011, at 11:24:47
In reply to Ach effecting Ca+ and SK, posted by B2chica on June 7, 2011, at 11:00:05
so Ach basically helps with absorption?
thus helping ca+ absorb? which in turns creates more and is an agonist to K?
still trying to understand relationship.thanks to any insights.
b2c.
Posted by desolationrower on June 13, 2011, at 21:55:26
In reply to Re: Ach effecting Ca+ and SK, posted by B2chica on June 8, 2011, at 11:24:47
> so Ach basically helps with absorption?
> thus helping ca+ absorb? which in turns creates more and is an agonist to K?
> still trying to understand relationship.
>
> thanks to any insights.
> b2c.I really haven't heard about these things in relationship before. Sorry I can't help.
-d/r
Posted by B2chica on June 15, 2011, at 10:16:20
In reply to Re: Ach effecting Ca+ and SK, posted by desolationrower on June 13, 2011, at 21:55:26
what about a basic role of Ach.
on zyprexa Ach(m) i've always done really well.
is it that it helps the 5ht-2a absorb more?
or effects the dopamine antagonist?i really wish i understood the workings of zyprexa better and why i've done so well on it in the past. if it werent for the large weight gain i get on it. i would be on it for life with no worries.
right now i'm headed down hill fast.
its bad and i dont think upping perphenazine will help as its only a Dopaminergic drug.
Posted by GoodOlJoe on June 15, 2011, at 17:54:05
In reply to Re: Ach effecting Ca+ and SK, posted by B2chica on June 15, 2011, at 10:16:20
Have you experimented with going on a low carb diet while taking zyprexa. Just a suggestion to you that may allow you to take it without weight gain.
if it werent for the large weight gain i get on it. i would be on it for life with no worries.
>
> right now i'm headed down hill fast.
> its bad and i dont think upping perphenazine will help as its only a Dopaminergic drug.
Posted by desolationrower on June 25, 2011, at 11:07:05
In reply to Re: Ach effecting Ca+ and SK, posted by B2chica on June 15, 2011, at 10:16:20
> what about a basic role of Ach.
> on zyprexa Ach(m) i've always done really well.
> is it that it helps the 5ht-2a absorb more?
> or effects the dopamine antagonist?
>
> i really wish i understood the workings of zyprexa better and why i've done so well on it in the past. if it werent for the large weight gain i get on it. i would be on it for life with no worries.
>
> right now i'm headed down hill fast.
> its bad and i dont think upping perphenazine will help as its only a Dopaminergic drug.olanzapine blocks 5ht2a (and c) receptors. I can't think of any important direct action between serotonin and acetylcholine, or olanzapine and acethylcholine (though it does block some muscarinic receptors. The TCAs do that too). The 5ht2 block is probably more responsible for mood lifting, but d2 might help deaden things too. both are part of the weight gain effect.
-d/r
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