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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by linkadge on March 23, 2010, at 0:34:55
The antidepressant citalopram decreases cb1 cannabanoid function while the tricyclic antidepressants appear to increase it.
http://www.springerlink.com/content/2127100x043n3674/
Conclusions These data provide evidence for reduced cannabinoid receptor-mediated G-protein coupling in the hypothalamus, hippocampus and medial geniculate nucleus of rats chronically treated with citalopram, effects which may, in part, underlie the mechanism of action of SSRIs.
http://www.cannabis-med.org/english/bulletin/ww_en_db_cannabis_artikel.php?id=219
Three-week administration of the tricyclic antidepressant desipramine resulted in a significant increase in the density of CB1 receptors in certain brain areas (hippocampus and hypothalamus) without significantly altering endocannabinoid levels. The reduction of stress-induced corticosterone secretion by the antidepressant was blocked by a CB1 receptor antagonist
Linkadge
Posted by europerep on March 23, 2010, at 0:34:56
In reply to differing cannbanoid effects TCA/SSRI, posted by linkadge on March 19, 2010, at 6:55:29
hm, this interesting, though I think I am not smart enough to draw any conclusions from this.. I am glad everytime I see someone is paying attention to the "bad receptors"..
this is not related, since the links do not actually talk about cannabis in depression, but in the past I have experienced a significant benefit from it. whenever I told that to someone I got the usual "yeahh, of course, it's an illegal drug, it's supposed to make you think it's good for you", but this approach is just soo superficial..
I had smoked cannabis occasionally some years ago, then I stopped, and I only resumed when someone offered it to me and I noticed how it helped me with depression. i.e., I did know how it was to just be high, and when I smoked in depression, it was very different from it. moreover, at the beginning especially, I myself mistrusted the effects induced immediately after smoking, but surprisingly, the antidepressant effect lasted throughout the following day.. "all of a sudden" I went to school the next morning, feeling rather good, enjoying talking to people, even participating in class - in short, being me again. I did not make the connection between the consumption and these "delayed" effects after months of smoking every now and then, and only feeling better the same day and the following.. in the end, I ended up smoking tiny amounts (0.1-0.2g of weed) even before school. this was surely not the best way of dealing with the depression, but it was the only way I was able to be myself again, in every aspect - socially, but also, during that time, my grades returned to where they were before depression etc.what I find most striking about these effects, in retrospective, is the immediate onset. there must be something different behind its antidepressant effects when compared to regular medication. I so much wish someone would investigate that - and possibly prove me wrong, maybe it was a high and nothing else, but I'd prefer to hear this from the scientific community instead of people having no idea of either depression or cannabis.
Posted by Laney on April 8, 2010, at 11:29:37
In reply to Re: differing cannbanoid effects TCA/SSRI, posted by europerep on March 23, 2010, at 0:34:56
regarding these articles?
Thanks!
Laney
Posted by Brainbeard on May 23, 2010, at 6:33:27
In reply to differing cannbanoid effects TCA/SSRI, posted by linkadge on March 23, 2010, at 0:34:55
These are just subjective experiences, but on TCA's, I often experience a kind of joyous glow that somehow feels similar to a marihuana high. It's not as strong, of course, but it feels like a mildly euphoric, creative mood. I play guitar and am a singer-songwriter; depression usually robs me of all fun I could have while engaging in playing the guitar and song-writing. Even low doses of a TCA, most notably imipramine and clomipramine, can give me back the glad feeling that there is something enchanting about the tones I hear and produce.
This MAY have something to do with cannabinoid receptors.
Experience often precedes scientific knowledge. I always felt that a marihuana high resembled a state of fever to some extent. Later I learnt that fever can be accompanied by a rush of endocannabinoids.
Posted by sigismund on June 8, 2010, at 17:03:25
In reply to Subjective Experiences: TCA's, Marihuana And Fever, posted by Brainbeard on May 23, 2010, at 6:33:27
>on TCA's, I often experience a kind of joyous glow
Really? How interesting.
This is the end of the thread.
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