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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 20 of 20. This is the beginning of the thread.
Posted by SLS on October 14, 2016, at 8:09:50
Does Saphris work to reduce psychotic symptoms?
Does Saphris work to improve depression?
Have you gained weight with Saphris?
- Scott
Posted by PeterMartin on October 15, 2016, at 13:53:06
In reply to How many people take Saphris (asenapine)?, posted by SLS on October 14, 2016, at 8:09:50
I'm sorry Scott I don't take it but I'd like to add a question if I may:
Is is true that its not a typical pill and you have to suck on it for 10minutes? (Take it sublingually). Was the taste/time to take it a deal breaker for anyone?
I think my doctor told me that when I brought it up once but I've never seen it mentioned here....
Posted by jonhed on October 15, 2016, at 17:04:16
In reply to Re: How many people take Saphris (asenapine)?, posted by PeterMartin on October 15, 2016, at 13:53:06
I'm also very interested in this particular drug.
It's been a long time since i was on an anti-psychotic but this one here seems like a well tolerated due to it's not so strong antagonism on dopamine = a small risk for eps and dystonia like symptoms.
I will be on dexamphetamine SIC for amphetamine addiction and I really need one AP that is not messing with the dopamine as much as lets say fluphenazine or perphenazine that I've been on before. I really likes trilafon though but the occular crisis is unbearable..But when i took trilafon and metylphenidate, it worked pretty well actually.
First and most important = no medications the first clean month too see if my delusional thinking fades, then if they're still there, yeah asenapine is definetly an option.
But what i long for the day that it will be nmda-antagonism instead of dopamine-blockade.
I was doing so very very good on memantine but my doctor don't want to write a script.
Sorry for hijacking your thread.
Hope someone with information writes a journal or just they're experiences.
Kind regards/J
Ps. Trilafon completely eliminated the paranoid thinking when i was in a drug induced psychosis for a long time. Too bad on the side effects though. [tip]
Posted by Jonhed on October 16, 2016, at 8:29:37
In reply to i'm on my way back from my relapse., posted by jonhed on October 15, 2016, at 17:04:16
Posted by Jeroen on October 17, 2016, at 13:52:59
In reply to sorry for rambling.. (nm), posted by Jonhed on October 16, 2016, at 8:29:37
sarcosine 2 ram gives me
vibrations in my penis
Posted by Jonhed on October 17, 2016, at 15:44:36
In reply to i wanna try saphris too, posted by Jeroen on October 17, 2016, at 13:52:59
Haha, what do you mean by that?
Are there any medications used to cope with akathisia?
I mean, Asenapine sounds really good.
Posted by SLS on October 17, 2016, at 15:54:53
In reply to i wanna try saphris too, posted by Jeroen on October 17, 2016, at 13:52:59
I tried Saphris for only a few weeks. I experienced a rather strong improvement in my bipolar depression, but it eventually disappeared - something that very often happens to me. My friend with schizoaffective disorder added Saphris to ongoing Navane (thiothixene) treatment. She responded to Saphris immediately. She experienced a dramatic improvement in depression and clarity of thought. She has been in remission for 3 years. She also lost the 30 pounds she gained when taking Abilify and Seroquel. My doctor has observed that Saphris is particularly effective when treating paranoia.
Good luck, Jeroen.
- Scott
Posted by SLS on October 17, 2016, at 15:57:04
In reply to Re: i wanna try saphris too, posted by Jonhed on October 17, 2016, at 15:44:36
Nice article.
http://bjp.rcpsych.org/content/196/2/89
- Scott
Posted by Jeroen on October 17, 2016, at 16:55:39
In reply to Re: i wanna try saphris too » Jeroen, posted by SLS on October 17, 2016, at 15:54:53
SLS, does Saphris give cardiac side effects?
i've read from various sources it has low cardiac problems, but some sources i've read some very bad stuff
dunno what to think of it, i think it's atleast better then seroquel that's sh*t and poison for me, it ruins my social life entirely because of the sedation.
Posted by Jonhed on October 18, 2016, at 7:14:04
In reply to Re: i wanna try saphris too » Jonhed, posted by SLS on October 17, 2016, at 15:57:04
Thanks Scott!
I've been on everything except amantadine and I must say that perphenazine decanoate 0.75-1.5ml (lower in the end) + 45mg diazepam was a very good regimen to cope with akathisia.Sadly when I tapered the diazepam I was starting to feel the akathisia from just 0.75ml perphenazine.. too bad.
Amantadine sounds interesting though, I've always liked natural alkaloids.
Thanks again!
Posted by Jeroen on October 18, 2016, at 7:30:47
In reply to Re: i wanna try saphris too, posted by Jonhed on October 18, 2016, at 7:14:04
be carefull with amantadine it helped me at first then psychotic symptoms came, then i tried seroquel normal one back in the days (it worked for 2 months) then pooped out in 2004
Posted by Christ_empowered on October 18, 2016, at 7:42:37
In reply to To Johned, posted by Jeroen on October 18, 2016, at 7:30:47
I don't think suppressing akathisia long term is the best idea. Tardive akathisia happens, its under-studied, and treatment is...difficult, assuming its even properly diagnosed.
But, I'm not an MD...just sharing my own opinion+fears (the last thing I want is permanent akathisia, personally).
Good luck!
Posted by Jonhed on October 18, 2016, at 8:24:32
In reply to Re: To Johned, posted by Christ_empowered on October 18, 2016, at 7:42:37
Yeah, the good ol fears. What would we be without them?
Yes, I know that to, it's a shame that everything comes with a price.
I will wait for the third generation antipsychotics I think, lol.
Posted by Jeroen on October 18, 2016, at 8:44:44
In reply to Re: To Johned, posted by Jonhed on October 18, 2016, at 8:24:32
Glycine
SarcosineITI-007 (scheduled for 2018)
Posted by Lamdage22 on October 27, 2016, at 12:43:27
In reply to 3rd generation anti psychotics already exist, posted by Jeroen on October 18, 2016, at 8:44:44
> ITI-007 (scheduled for 2018)
Lumateperone. THanks for sharing.
Posted by SLS on October 27, 2016, at 18:36:31
In reply to 3rd generation anti psychotics already exist, posted by Jeroen on October 18, 2016, at 8:44:44
> ITI-007 (scheduled for 2018)
lumateperone
Interesting drug. I would try it myself if I were not taking a MAOI. Lumateperone is a serotonin reuptake inhibitor. When it is combined with a MAOI, there is a risk of setoronin syndrome.
The one thing I didn't see was the blockade of 5-HT7 receptors as is seen in aripiprazole and lurasidone. Vortioxetine, an antidepressant, also blocks 5-HT7. Researchers think that this property contributes to antidepressant action.
- Scott
Posted by Lamdage22 on October 28, 2016, at 6:01:55
In reply to Re: 3rd generation anti psychotics already exist, posted by SLS on October 27, 2016, at 18:36:31
Do you think it can be combined with 50mg trazodone?
> > ITI-007 (scheduled for 2018)
>
> lumateperone
>
> Interesting drug. I would try it myself if I were not taking a MAOI. Lumateperone is a serotonin reuptake inhibitor. When it is combined with a MAOI, there is a risk of setoronin syndrome.
>
> The one thing I didn't see was the blockade of 5-HT7 receptors as is seen in aripiprazole and lurasidone. Vortioxetine, an antidepressant, also blocks 5-HT7. Researchers think that this property contributes to antidepressant action.
>
>
>
>
> - Scott
Posted by SLS on October 28, 2016, at 6:36:30
In reply to Re: 3rd generation anti psychotics already exist, posted by Lamdage22 on October 28, 2016, at 6:01:55
> Do you think it can be combined with 50mg trazodone?
I think the risk of developing serotonin syndrome would be small. Doctors will sometimes use trazodone for sleep in people taking Parnate. To my knowledge, MAOIs are the most dangerous drugs when a serotonin reuptake inhibitor like trazodone is added. Trazodone is a moderate SRI at best, though. So, my guess is that it would be safe to combine Trazodone and lumateperone. It would be prudent to put together a list of symptoms of SS. Alternatives for improving sleep would include amitriptyline, Seroquel and Remeron. Weight-gain is a problem with these drugs, though.Can you describe in what ways your sleep is disturbed? Is it more difficult to fall asleep or, rather, to remain asleep?Some people find melatonin to be effective for both. It is usually taken one hour before going to sleep. What time do you wake up in the morning?
- Scott
______________________________________________________________
> > > ITI-007 (scheduled for 2018)> > lumateperone
> >
> > Interesting drug. I would try it myself if I were not taking a MAOI. Lumateperone is a serotonin reuptake inhibitor. When it is combined with a MAOI, there is a risk of setoronin syndrome.
> >
> > The one thing I didn't see was the blockade of 5-HT7 receptors as is seen in aripiprazole and lurasidone. Vortioxetine, an antidepressant, also blocks 5-HT7. Researchers think that this property contributes to antidepressant action.
.
Posted by Lamdage22 on October 28, 2016, at 10:24:49
In reply to Re: 3rd generation anti psychotics already exist, posted by SLS on October 28, 2016, at 6:36:30
> Can you describe in what ways your sleep is disturbed? Is it more difficult to fall asleep or, rather, to remain asleep?Some people find melatonin to be effective for both. It is usually taken one hour before going to sleep. What time do you wake up in the morning?
I dont take trazodone for sleep. It actually makes falling asleep very difficult for me because while falling asleep i feel psychotic on it. Awake its okay, asleep its okay, but in between, its horror.
I lose weight from Trazodone and i get more motivation to do things plus a tad better mood.
I wake up at 9am and take 75mg Trazodone right after. It does not make me tired.
Posted by Lamdage22 on October 28, 2016, at 14:07:35
In reply to Re: 3rd generation anti psychotics already exist, posted by Lamdage22 on October 28, 2016, at 10:24:49
I take it in the morning because then i am awake afterwards and i dont have to feel psychotic like when i took it at bedtime.
This is the end of the thread.
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