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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 12 of 12. This is the beginning of the thread.
Posted by joe f on December 30, 2014, at 13:02:04
even though Cymbalta has norephrinephrine for many it is not activating...any thoughts
Posted by former poster on December 30, 2014, at 13:51:38
In reply to cymbalta, posted by joe f on December 30, 2014, at 13:02:04
I miss Cymbalta. The most effective AD in my opinion. Sadly, almost destroyed my love life.
Posted by SLS on December 30, 2014, at 14:06:16
In reply to Re: cymbalta » joe f, posted by former poster on December 30, 2014, at 13:51:38
> I miss Cymbalta. The most effective AD in my opinion. Sadly, almost destroyed my love life.
What about combining Cymbalta or Pristiq with Wellbutrin? Some people even find Buspar helpful to recover libido.
- Scott
Posted by SLS on December 30, 2014, at 14:26:26
In reply to cymbalta, posted by joe f on December 30, 2014, at 13:02:04
> even though Cymbalta has norephrinephrine for many it is not activating...any thoughts
It is tricky to try to predict the behavior of a drug in real life based upon what is observed in the laboratory or the theories offered by researchers. Often, a new property will be discovered for an old drug that which comes to explain inconsistencies in previous theories. Nortriptyline, a drug that was categorized primarily as a norepinephrine reuptake inhibitor was found to be soporific and anxiolytic in some people. As technology and understanding grew, it was found that nortriptyline was also a potent serotonin 5-HT2a antagonist.
Even if we were able to offer a guess about Cymbalta based upon a simple model, it is important to note that Cymbalta is at least 10 times stronger as a reuptake inhibitor of serotonin than of norepinephrine.
- Scott
Posted by joe f on December 30, 2014, at 15:41:31
In reply to Re: cymbalta » joe f, posted by SLS on December 30, 2014, at 14:26:26
so 10:1 in favor of serotonin is it weaker than Effexor and pristique on norephrinine....did your body feel better as a whole on it?
Posted by Phillipa on December 30, 2014, at 16:19:58
In reply to Re: cymbalta, posted by joe f on December 30, 2014, at 15:41:31
No back or body pain when took 60mg when living at beach. Was only when got a computer that I scared myself off it. And I did not ever have an withdrawal problems in the past with any med. Back when 24 given mepbrobamate 450 mg with 15mg of valium and one day dropped the mepbrobamate and never missed it. Phillipa
Posted by vbs on December 30, 2014, at 16:31:59
In reply to cymbalta, posted by joe f on December 30, 2014, at 13:02:04
I take 90 mg /day and find that it does not jazz me up. Overall effective, especially when combined with some coffee.
Posted by former poster on December 30, 2014, at 17:09:01
In reply to Re: cymbalta, posted by SLS on December 30, 2014, at 14:06:16
I tried combining Cymbalta with bupropion and it was marginally beneficial for mood, libido and dysfunction. Definitely a plus. I may try it again someday. Tried Pristiq alone after stopping Cymbalta and it was the same or worse for sexual side effects with little benefit for anxiety.
Posted by SLS on December 30, 2014, at 17:34:38
In reply to Re: cymbalta » SLS, posted by former poster on December 30, 2014, at 17:09:01
What about Viibryd (vilazodone)?
Viibryd acts as a serotonin reuptake inhibitor and 5-HT1A receptor partial agonist. It is known for not producing a reduction in sex-drive. When I took it, I experienced no sexual side effects at all.
- Scott
Posted by joe f on December 30, 2014, at 17:53:02
In reply to Re: cymbalta » former poster, posted by SLS on December 30, 2014, at 17:34:38
phillipa what do you mean you scared yourself off of it?
Posted by Phillipa on December 30, 2014, at 19:51:36
In reply to Re: cymbalta, posted by joe f on December 30, 2014, at 17:53:02
Found this site and saw what others were writing about the med at the time. Was newly released then. P
Posted by joe f on December 31, 2014, at 5:21:16
In reply to Re: cymbalta » joe f, posted by Phillipa on December 30, 2014, at 19:51:36
would you be scared now?
This is the end of the thread.
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