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Re: cymbalta » joe f

Posted by SLS on December 30, 2014, at 14:26:26

In reply to cymbalta, posted by joe f on December 30, 2014, at 13:02:04

> even though Cymbalta has norephrinephrine for many it is not activating...any thoughts

It is tricky to try to predict the behavior of a drug in real life based upon what is observed in the laboratory or the theories offered by researchers. Often, a new property will be discovered for an old drug that which comes to explain inconsistencies in previous theories. Nortriptyline, a drug that was categorized primarily as a norepinephrine reuptake inhibitor was found to be soporific and anxiolytic in some people. As technology and understanding grew, it was found that nortriptyline was also a potent serotonin 5-HT2a antagonist.

Even if we were able to offer a guess about Cymbalta based upon a simple model, it is important to note that Cymbalta is at least 10 times stronger as a reuptake inhibitor of serotonin than of norepinephrine.


- Scott


Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw

 

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