![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 16 of 16. This is the beginning of the thread.
Posted by SLS on March 14, 2014, at 19:31:15
NIH rethinks psychiatry trials
Mental-health division will no longer fund research aiming to relieve symptoms without probing underlying causes.
http://www.nature.com/news/nih-rethinks-psychiatry-trials-1.14877
- Scott
Posted by Phillipa on March 14, 2014, at 22:16:55
In reply to NIMH funding - a new paradigm., posted by SLS on March 14, 2014, at 19:31:15
Scott so what are your thoughts on this? Phillipa
Posted by LostBoyinNC45 on March 15, 2014, at 9:23:26
In reply to NIMH funding - a new paradigm., posted by SLS on March 14, 2014, at 19:31:15
One of the commentors at the bottom, "Kevin Owen," he sounds like a fruitcake. He posts, "What they don't realise is that many of the symptoms maybe biological but have a Psychosomatic Cause. You can't treat Psychosomatic Illness with Physical Treatments, Current trends have shown that having no cure for any illness."
WTF? I never heard that Axis 1 level, major psychiatric illnesses were/are caused by "psychosomatic" causes. LOL This is the thinking of a fruitcake, this Owens poster.Axis 1 level, psychiatric disorders ARE physical illnesses of the brain. PERIOD. Ive been saying it for years. Once you become clinically depressed that first time, once you experience that very first major depressive breakdown, serotonin levels tend to stay down for the rest of your life. The trick, the key, is to find drugs/treatments that will reverse by pharmacological force this sort of chronic nervous system deterioration.
We also need to get rid of these "is mostly the environment" versus the genes and the nervous system crowd in psychiatry and psychology. Those people need to take a hike...they hold us all back with their refusal to let go of their "its the environment, stupid" attitude. Most of them are left wingers who dont like genetics studies to begin with.
Ive been saying it for years and years and I know I am right. Until this sh*t starts getting taken seriously as a real brain illness, we will all just be spinning our gears so to speak, taking prescription drugs with a shot in the dark approach. Sometimes the drugs work great, sometimes the drugs barely work at all and probably most, the drugs work fairly decently but nowhere near as well as the drug companies would lead us all to believe with their marketing.
Id also like to see MORE research linking sleep disorders to mental health. Ive read so much research that says that untreated sleep apnea leads to decreased serotinin levels, increased adrenaline and cortisol during sleep...psychiatry ignores an entire 1/3 of the day of whats going on in our bodies by ignoring aggressive research of sleep disorders, instead leaving it totally to pulmonary specialist sleep medicine physicians and to Neurologists...whose main interests are cardiopulmonary diseases and not "mood and thinking."
It is FUBAR, IMO. Its also obvious NIMH has no real leadership, psychiatry has poor leadership as an institution. Just shoddy, low quality.
Eric AKA "LostBoyinNC"
Posted by SLS on March 15, 2014, at 12:22:24
In reply to Re: NIMH funding - a new paradigm., posted by LostBoyinNC45 on March 15, 2014, at 9:23:26
> One of the commentors at the bottom, "Kevin Owen," he sounds like a fruitcake.
What does a fruitcake sound like?
It seems to me that you could use some more research on psychosomatic medicine in order to produce a cogent commentary.
As for the rest...
I hate hate.
- Scott
Posted by SLS on March 15, 2014, at 13:44:11
In reply to Re: NIMH funding - a new paradigm. » SLS, posted by Phillipa on March 14, 2014, at 22:16:55
> Scott so what are your thoughts on this? Phillipa
My initial reaction was one of resistance to the idea. However, I think it makes a great deal of sense. The pharmaceutical companies are fully capable of funding their own research into producing effective drugs. I think that there could be more oversight of their studies, though. The proposed change will affect only those studies that are to be funded by the NIH. The requirement that the design of an investigation of a drug includes the elucidation of its mechanisms of action and the pathology that produces the disorder being studied is important if we are to advance our understanding of mental illness.
When I was a research patient at the NIH clinical center, they had me try idazoxan, an experimental compound known to act somewhat like Remeron. It was a NE alpha-2 antagonist. Part of the deal was that, in order to receive this medication, I had to submit myself to a weekly battery of blood and urine tests. I also agreed to have cerebrospinal fluid collected via lumbar puncture (spinal-tap). However, the most salient observations were made during PET scans of how my brain reacted to idazoxan. Of course, they wanted clinical data to see if it would work for me. It actually made me worse. This study would be eligible for funding under the new criteria. They used idazoxan as a probe into the workings of the brain. A simple clinical trial focused on symptomatology only would not be eligible.
- Scott
Posted by LostBoyinNC45 on March 15, 2014, at 13:53:34
In reply to Re: NIMH funding - a new paradigm. » LostBoyinNC45, posted by SLS on March 15, 2014, at 12:22:24
Honestly, a fruitcake sounds kinda like you sound on here. You sound like a nut. You should move to California, if you dont already live there.
Eric AKA "LostBoyinNC"
> > One of the commentors at the bottom, "Kevin Owen," he sounds like a fruitcake.
>
> What does a fruitcake sound like?
>
> It seems to me that you could use some more research on psychosomatic medicine in order to produce a cogent commentary.
>
> As for the rest...
>
> I hate hate.
>
>
> - Scott
Posted by Toph on March 15, 2014, at 14:55:29
In reply to Re: NIMH funding - a new paradigm., posted by LostBoyinNC45 on March 15, 2014, at 9:23:26
> Those people need to take a hike...they hold us all back with their refusal to let go of their "its the environment, stupid" attitude. Most of them are left wingers who dont like genetics studies to begin with.
>Thank God for the right wingers, most of whom I'm told support genetic studies. Where would we be without them?
Posted by Dr. Bob on March 15, 2014, at 15:09:42
In reply to Re: SLS is a fruitcake, posted by LostBoyinNC45 on March 15, 2014, at 13:53:34
> SLS is a fruitcake
Calling someone a fruitcake could lead them to feel put down.
More information about posting policies and tips on alternative ways to express yourself, including a link to a nice post by Dinah on I-statements, are in the FAQ:
http://www.dr-bob.org/babble/faq.html#civil
http://www.dr-bob.org/babble/faq.html#enforceFollow-ups regarding these issues should be redirected to Psycho-Babble Administration. They, as well as replies to the above post, should of course themselves be civil.
Thanks,
Bob
PS: This block is the result of one action, but its length is the result of a pattern of actions. The block length formula:
http://www.dr-bob.org/babble/faq.html#enforce
takes into account how long the previous block was, how long it's been since the previous block, and how uncivil the current post is:
duration of previous block = 1 week
period of time since previous block = 1 week
severity = 2 (default)+ 1 (uncivil toward particular individual)= 3
block length = 2.94 rounded = 3 weeks
Posted by 10derheart on March 15, 2014, at 19:06:32
In reply to Re: SLS is a fruitcake, posted by LostBoyinNC45 on March 15, 2014, at 13:53:34
Eric...Eric...Eric...
Oh well.
See ya next time.
I still hold out hope, somehow.
Posted by Phillipa on March 15, 2014, at 20:35:53
In reply to Re: NIMH funding - a new paradigm. » Phillipa, posted by SLS on March 15, 2014, at 13:44:11
In other words seeing is believing. Phillipa
Posted by phidippus on March 15, 2014, at 22:20:17
In reply to Re: SLS is a fruitcake, posted by LostBoyinNC45 on March 15, 2014, at 13:53:34
We're all fruitcakes here, mr. poopy pants.
Eric
Posted by SLS on March 15, 2014, at 22:39:28
In reply to Re: NIMH funding - a new paradigm. » SLS, posted by Phillipa on March 15, 2014, at 20:35:53
> In other words seeing is believing. Phillipa
I'm not sure what you mean by that.
- Scott
Posted by Phillipa on March 15, 2014, at 22:48:17
In reply to Re: NIMH funding - a new paradigm. » Phillipa, posted by SLS on March 15, 2014, at 22:39:28
Scientific imaging of brain shows changes hence person responds either well or bad. Phillipa
Posted by SLS on March 15, 2014, at 23:32:12
In reply to Re: NIMH funding - a new paradigm. » SLS, posted by Phillipa on March 15, 2014, at 22:48:17
> Scientific imaging of brain shows changes hence person responds either well or bad. Phillipa
This is a great idea, Phillipa. I agree. I think that an algorithm can be developed to use imaging to observe how an individual's brain reacts to a series of biological and behavioral challenges. The results of this examination might very well allow doctors to choose treatments with greater precision. For example, if a NE alpha-2 receptor antagonist probe causes the prefrontal cortices to "light up", one might then choose Remeron first as a treatment for depression. I would think PET scans would produce more useful information than the SPECT scans endorsed by Daniel Amen. I believe there are some facilities that can superimpose PET onto MRI.
Thanks to contemporary translational medicine, pure neuroscience research is producing information that has clinical relevance. One of my NIH doctors has made a career of this. I am proud to say that I was his first attempt at lumbar puncture. In certain circumstances, it is not so good to be number one. Ouch.
- Scott
Posted by SLS on March 16, 2014, at 0:39:33
In reply to Re: SLS is a fruitcake, posted by LostBoyinNC45 on March 15, 2014, at 13:53:34
> Honestly, a fruitcake sounds kinda like you sound on here. You sound like a nut. You should move to California, if you dont already live there.
So, you managed to disparage me, fruitcakes, nuts, and the state of California in just a handful of words. That's impressive. I don't care what you say about me, but I think fruitcakes deserve more respect. They are the butt of an endless procession of jokes during the holiday season. I happen to love fruitcakes. The heavier, the better, especially when they contain nuts. Should I receive a fruitcake from my relatives from California, I would still enjoy it. Fruitcakes never seem to go bad. So, it seems that your commentary on my sounding like a fruitcake is really quite a compliment when you consider that I should never go bad. I must infer from your words that you do not consider yourself to be a fruitcake. Don't be so hard on yourself.
I'm not a real big fan of bashing people while they are being blocked, so I tried to keep things civil in my desire to package and sequester these issues until you return, if that be your intention.
We both know why your posts so often animate people to respond to them. You should expect nothing less as a consequence of your posts than to have people challenge you using the best tools that they have available to them. I know that you can do better than to call someone a fruitcake when your words and ideas are challenged.
I see two types of writing coming from you. One is intelligent, sophisicated, well-informed, and reasonably objective in approach. It deserves a great deal of respect, even if others offer alternative opinions. Your writing and the perspectives it portrays often encourage thought. As for the second type of writing that you produce, I shall try not to opine on it until you return. Perhaps you can consider it in the interim.
- Scott
Posted by Willful on March 17, 2014, at 10:49:31
In reply to Re: SLS is a fruitcake » LostBoyinNC45, posted by SLS on March 16, 2014, at 0:39:33
I like fruitcakes too!
This is the end of the thread.
Psycho-Babble Medication | Extras | FAQ
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.org
Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.