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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by Jay_Original1 on January 17, 2014, at 22:18:07
I really hope someone can help me out. I am really afraid of TD, so my doc started me on a low dose of 50mg of Thorazine (chlopromazine) at bedtime. Last night it seemed to work in calming me down, but not tonight. Now, I have to say, I am a pretty big guy, and it takes between 20-30mg of Zyprexa to calm me down. I am afraid of increasing the Thorazine dose because of my fear of td. If I took a couple hundred mg's of Thorazine, would I be alright?
Thanks so much...
Jay
Posted by SLS on January 17, 2014, at 22:41:06
In reply to SLS/anyone. Safest highest dose of Thorazine?, posted by Jay_Original1 on January 17, 2014, at 22:18:07
> I really hope someone can help me out. I am really afraid of TD, so my doc started me on a low dose of 50mg of Thorazine (chlopromazine) at bedtime. Last night it seemed to work in calming me down, but not tonight. Now, I have to say, I am a pretty big guy, and it takes between 20-30mg of Zyprexa to calm me down. I am afraid of increasing the Thorazine dose because of my fear of td. If I took a couple hundred mg's of Thorazine, would I be alright?
>
> Thanks so much...
> JayHi Jay.
I don't know enough about Thorazine to be able to comment on its use.
Is sleep the main issue or are there other issues involving hypomania?
Have you tried Depakote?
- Scott
Posted by sigismund on January 17, 2014, at 22:50:35
In reply to Re: SLS/anyone. Safest highest dose of Thorazine? » Jay_Original1, posted by SLS on January 17, 2014, at 22:41:06
It's not very nice. Try 100 before you go higher.
But people with schizophrenia forever ago were on maybe 800, I dunno. The nurses used to wheel them out into the sunlight so they could burn easliy, some photosensitivity thing that will not be an issue where you are.
Don't go taking 200 or more before you try less.
Posted by rjlockhart37 on January 17, 2014, at 23:26:10
In reply to Re: SLS/anyone. Safest highest dose of Thorazine?, posted by sigismund on January 17, 2014, at 22:50:35
if you take thorazine with zyprexa at 30mgs, thats really confusing because it can defiently cause it....
go to 100mgs and keep the zyprexa at 15mgs, if you do have a TD syndrome, tell your doctor to prescribe Cogentin, or similar drugs to it. It's used for parkinson's disorder but it does the same thing, it levelizes the dopamine levels that anitpsychotics lower and cause TD
this also should be some intrest:
http://www.skeptictank.org/treasure/MEDICAL/ANTIPSYC.HTMseriously ask about Ativan....and if benzos are not in the picture, Kava Kava Root, it will resemble a moderate benzo effect.
take care...
r
Posted by Christ_empowered on January 18, 2014, at 13:38:58
In reply to Re: SLS/anyone. Safest highest dose of Thorazine?, posted by rjlockhart37 on January 17, 2014, at 23:26:10
I did some googling. The atypicals are nicer, usually, than good ole thorazine, but they can still convert them into Thorazine (CPZ) units, just like the old ones.Its works like this: 100mgs/Thorazine=2mgs/Haldol= (according to my googling...)...75/Seroquel, 5/Zyprexa, 7.5 Abilify.
At high doses, Thorazine is the worst thing ever. At lower doses, the EPS is actually comparable to some of the atypials (remember, thorazine has an anti-cholinergic component, so that helps reduce EPS) and the dysphoria isn't so terrible. I seem to recall reading that akathisia is, however, still an issue at lower doses for some people.Anyway, like sigisimund said, I'd try 100 before you go popping a handful. In the US back in the day, docs would commonly go up into several hundreds, even above 1 gram, of Thorazine per day. Not surprisingly...bad things happened :-( Keep in mind, back then docs were taught that Parkinsonism was an important sign that the drug was working. Apparently, dull eyes, stiff gait, and tremor=successful treatment. Thank you, psychiatry.
I'd try, personally, to keep it at or under 300mgs/day. If I recall from "Mad in America" correctly (there was a lot of older literature in there), 300mgs/day was found to be quite useful in "ambulatory" outpatients in the UK and parts of Europe. For whatever reasons (probably cultural), American docs had a tendency to ramp up the doses considerably, especially on poor inpatients.
Good luck!
Posted by SLS on January 18, 2014, at 15:20:38
In reply to Re: SLS/anyone. Safest highest dose of Thorazine?, posted by Christ_empowered on January 18, 2014, at 13:38:58
>
> I did some googling. The atypicals are nicer, usually, than good ole thorazine, but they can still convert them into Thorazine (CPZ) units, just like the old ones.
>
> Its works like this: 100mgs/Thorazine=2mgs/Haldol= (according to my googling...)...75/Seroquel, 5/Zyprexa, 7.5 Abilify.
>
>
> At high doses, Thorazine is the worst thing ever. At lower doses, the EPS is actually comparable to some of the atypials (remember, thorazine has an anti-cholinergic component, so that helps reduce EPS) and the dysphoria isn't so terrible. I seem to recall reading that akathisia is, however, still an issue at lower doses for some people.
>
> Anyway, like sigisimund said, I'd try 100 before you go popping a handful. In the US back in the day, docs would commonly go up into several hundreds, even above 1 gram, of Thorazine per day. Not surprisingly...bad things happened :-( Keep in mind, back then docs were taught that Parkinsonism was an important sign that the drug was working. Apparently, dull eyes, stiff gait, and tremor=successful treatment. Thank you, psychiatry.I didn't know that.
> I'd try, personally, to keep it at or under 300mgs/day. If I recall from "Mad in America" correctly (there was a lot of older literature in there), 300mgs/day was found to be quite useful in "ambulatory" outpatients in the UK and parts of Europe. For whatever reasons (probably cultural), American docs had a tendency to ramp up the doses considerably, especially on poor inpatients.
The history of psychiatry and its treatment of the mentally ill is very, very sad.
- Scott
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