![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 7 of 7. This is the beginning of the thread.
Posted by SLS on July 8, 2013, at 6:45:36
Lurasidone Approved for Bipolar Depression
June 28, 2013
The US Food and Drug Administration (FDA) has approved lurasidone (Latuda, Sunovion Pharmaceuticals), already indicated for schizophrenia, to treat major depressive episodes in adults with bipolar 1 disorder, the manufacturer announced last Friday.
Clinicians can prescribe lurasidone by itself or together with either lithium or valproate for this new indication.
Sunovion Pharmaceuticals stated in a news release that the FDA decision was supported by 2 clinical trials, one for lurasidone as an adjunctive therapy (PREVAIL1), and the other for the drug as a monotherapy (PREVAIL2).
In both trials, patients taking lurasidone experienced a reduction in depressive symptoms as measured by the Montgomery-Asberg Depression Rating Scale after 6 weeks compared with the group on a placebo. Patients taking lurasidone scored statistically significant improvements on other measures of mental health that consider such things as remission rates, anxiety symptoms, and enjoyment and quality of life, according to the manufacturer.
Akathisia, extrapyramidal symptoms, somnolence, nausea, vomiting, diarrhea, and anxiety were the most common adverse events for patients taking lurasidone as a monotherapy. In the study of lurasidone as an adjunctive therapy, the most common adverse reactions were akathisia and somnolence. Discontinuation rates stemming from adverse events were 6% for patients taking lurasidone by itself and 5.8% for those taking it along with lithium or valproate. Among patients in both studies who received a placebo, the discontinuation rate was about 5%.
Posted by bk2va32 on July 8, 2013, at 9:31:11
In reply to Latuda (lurasidone) Approved - Bipolar Depression, posted by SLS on July 8, 2013, at 6:45:36
I tried it for a few weeks and noticed nothing but anger....so im on zyprexa at night but wafers which i HOPE HOLD TRUE that wafers lack the weight gain
Posted by Phil on July 8, 2013, at 15:03:15
In reply to Re: Latuda (lurasidone) Approved - Bipolar Depression, posted by bk2va32 on July 8, 2013, at 9:31:11
It's listed as causing weight gain. Maybe they mean 50 pounds instead of 60 in the first 4 months.
I'm not a real big fan of Zyprexa. Six days in the hospital does that to you. But good luck and I can't wait to hear how this does for you.
If you like the drug but are piling on weight Metformin took 30 pounds off of me in around 60 days. Friggin miracle.
Headaches
Drowsiness or dizziness
Increased appetite or unusual weight gain
Memory problems
Loss of bladder control
Upset stomach or constipation
Back or muscle pain
Tingling or numbness
Swelling or discharge from the breast area
Disrupted menstrual cycle
Posted by bk2va32 on July 8, 2013, at 18:26:29
In reply to Re: Latuda (lurasidone) Approved - Bipolar Depression » bk2va32, posted by Phil on July 8, 2013, at 15:03:15
I agree i dident like it either
Posted by Beckett on July 8, 2013, at 20:11:49
In reply to Re: Latuda (lurasidone) Approved - Bipolar Depression, posted by bk2va32 on July 8, 2013, at 18:26:29
I had one of the worst reactions to that med. Deepened my depression.
Yes, I know we are all different .
Posted by SLS on July 8, 2013, at 20:20:02
In reply to Re: Latuda (lurasidone) Approved - Bipolar Depression, posted by Beckett on July 8, 2013, at 20:11:49
> I had one of the worst reactions to that med. Deepened my depression.
>
> Yes, I know we are all different .We'll have to see how well Latuda works in the real world. I did not react well to it. I experienced brain-fog cognitive blunting early in treatment with it. I may have discontinued it prematurely, though.
- Scott
Posted by porkpiehat on July 14, 2013, at 12:42:13
In reply to Re: Latuda (lurasidone) Approved - Bipolar Depression, posted by SLS on July 8, 2013, at 20:20:02
I added it my small dose of Celexa as an adjunct a few weeks ago and it helped with the depression almost immediately. Not sure if I will stay on it due to grogginess and anger/aggressiveness and drop in sex drive.
Strangely my Lamictal, which was always activating in conjunction with the Celexa, now seems to exaccerbate the mind fog.
YMMV of course!
This is the end of the thread.
Psycho-Babble Medication | Extras | FAQ
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.org
Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.