Psycho-Babble Medication Thread 1012100

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Nortriptyline for 10 days now. Update

Posted by Laney on March 1, 2012, at 11:13:54

So I've been on it like 10 days. It's not working yet. It seems like it worked so quickly last time. How long do you think I should give it? My doc wants me up to 75mg. I'm at 50mg.

What are the main differences between Nort. and Clomiprimine? Just looking ahead.

Thanks as usual,

Laney

Re: Nortriptyline for 10 days now. Update » Laney

Posted by Phillipa on March 1, 2012, at 12:02:45

In reply to Nortriptyline for 10 days now. Update, posted by Laney on March 1, 2012, at 11:13:54

Clomipramine is very strong used a lot for OCD. I'm sorry it's doing nothing yet. Phillipa

Re: Nortriptyline for 10 days now. Update » Laney

Posted by SLS on March 1, 2012, at 13:00:10

In reply to Nortriptyline for 10 days now. Update, posted by Laney on March 1, 2012, at 11:13:54

> So I've been on it like 10 days. It's not working yet. It seems like it worked so quickly last time. How long do you think I should give it? My doc wants me up to 75mg. I'm at 50mg.
>
> What are the main differences between Nort. and Clomiprimine? Just looking ahead.
>
> Thanks as usual,
>
> Laney

Most people do not respond to nortriptyline until they reach a dosage of 75 mg. If you have a fast metabolism, you might need as much as 150 mg. For nortriptyline, it is worth getting a blood test for drug levels. I need 150 mg in order to respond. I am an "extensive metabolizer". My blood levels at 150 mg are still below the maximum. The reference range for the blood test is between 50 - 150 ng/ml.

Nortriptyline is a unique drug among the tricyclics. Unlike the others, one can actually lose the antidepressant response if the dosage is too high. This phenomenon is known as a "therapeutic window".

I think it is too early to be worried at this point. It is unlikely that you would respond to 50 mg, even if you stayed at that dosage for a month.

I hope you are able to recapture you original response to nortriptyline. You'll let us know?

Good luck.

- Scott

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