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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 16 of 16. This is the beginning of the thread.
Posted by Johnny32 on October 27, 2009, at 17:00:59
Anybody has a clue?
Posted by Phillipa on October 28, 2009, at 0:25:13
In reply to Triple Reuptake Inhibitors. When?, posted by Johnny32 on October 27, 2009, at 17:00:59
Umm my ignorance is showing what are they supposed to do? Phillipa
Posted by softheprairie on October 28, 2009, at 1:41:49
In reply to Triple Reuptake Inhibitors. When?, posted by Johnny32 on October 27, 2009, at 17:00:59
MAO inhibitors already act on serotonin, norepinephrine, and dopamine, I believe.
But, as to the specific question you asked, I'm not sure.
Posted by hopefullynow on October 28, 2009, at 6:08:05
In reply to Re: Triple Reuptake Inhibitors. When?, posted by softheprairie on October 28, 2009, at 1:41:49
As a matter of fact if I'm not wrong there is a med,an triple reuptake inhibitor: Sibutramine (Meridia)which is claimed to affect all the three neurotransmitters, at various degrees.When it came up, it was clinically tested for depression but shown up as a better appetite suppresant.Looks that it have a short half-life, but it's metabolites named M1 and M2 have a longer hal-life (15h, or so).I tried it and I felt the dopaminergic side, slight but sesizable.Indeed, as an antidepressant wasn't as strong as an TCA, more like an SSRI.For me, was so and so.I trialed it as an appetite suppresant and being as generic and sold without prescription, I gave it a go.Look here:
http://en.wikipedia.org/wiki/Sibutramine
Posted by Netch on October 28, 2009, at 8:01:02
In reply to Re: Triple Reuptake Inhibitors. When?, posted by hopefullynow on October 28, 2009, at 6:08:05
A couple of years. DOV Pharmaceutical has done Phase I and Phase II tests.
" DOV Pharmaceutical, Inc. is a biopharmaceutical company historically focused on the development of novel product candidates for disorders of the central nervous system. The Company has previously funded drug development programs that are now at the preclinical, Phase I and Phase II clinical stages, including DOV 21,947 (which has completed a pilot Phase 2 clinical trial), DOV 102,677 (which has completed a Phase I clinical trial) and a preclinical discovery program in reuptake inhibitors and GABA modulators. The Company has sublicensing agreements for the development and commercialization of certain product candidates with XTL Biopharmaceuticals, for bicifadine, with Blue Note Pharmaceuticals, for DOV diltiazem and with Neurocrine Biosciences, or Neurocrine, for indiplon..
DOV 21,947, is a triple reuptake inhibitor (serotonin, norepinephrine and dopamine inhibitor), or TRI, with potential efficacy in the treatment of depression and obesity. DOV 102,677 is another TRI, with potential efficacy in the treatment of alcohol abuse.. "
Posted by uncouth on October 28, 2009, at 11:29:41
In reply to Re: Triple Reuptake Inhibitors. When?, posted by Netch on October 28, 2009, at 8:01:02
In my opinion, I wouldn't put too much fo your hope in a triple reuptake inhibitor. you can emulate triple reuptake with a combination of SSRI and bupoprion ,which is a safe combo used for many years. or, there are MAOIs, atypical antipsychotics, and lithium.
And dont' forget about agomelatine!
Lots of choices out there. Instead of waiting for a drug that simply combines known methods of actions, I think it's better to try hitting things from different angles. that's why i'm on my particular cocktail:
wellbutrin
lithium
agomelatine
deplin
zyprexanote: there is no SSRI. but this has been working for me. i'm BP2, primarily depressive. SSRIs tend to put me in a mixed/impulsive state. i say and do things i later regret.
anyway ,good luck.
Posted by bulldog2 on October 28, 2009, at 14:26:31
In reply to Re: Triple Reuptake Inhibitors. When?, posted by uncouth on October 28, 2009, at 11:29:41
> In my opinion, I wouldn't put too much fo your hope in a triple reuptake inhibitor. you can emulate triple reuptake with a combination of SSRI and bupoprion ,which is a safe combo used for many years. or, there are MAOIs, atypical antipsychotics, and lithium.
>
> And dont' forget about agomelatine!
>
> Lots of choices out there. Instead of waiting for a drug that simply combines known methods of actions, I think it's better to try hitting things from different angles. that's why i'm on my particular cocktail:
>
> wellbutrin
> lithium
> agomelatine
> deplin
> zyprexa
>
> note: there is no SSRI. but this has been working for me. i'm BP2, primarily depressive. SSRIs tend to put me in a mixed/impulsive state. i say and do things i later regret.
>
> anyway ,good luck.Also use a stimulant such as ritalin, adderrall or the new vyvanse. Combine withan ssri. The problem with snri or a triple reuptake drug is you can't control the ratios as you can with multiple drugs.
Posted by Johnny32 on October 28, 2009, at 17:19:30
In reply to Re: Triple Reuptake Inhibitors. When?, posted by uncouth on October 28, 2009, at 11:29:41
I'm afraid that combining multiple pills will increase side effects, that's why I was asking about triple uptake inhibitors (In trials, they had fewer side effects than SSRIs)
Posted by Larry Hoover on October 28, 2009, at 21:40:09
In reply to Triple Reuptake Inhibitors. When?, posted by Johnny32 on October 27, 2009, at 17:00:59
St. John's wort exerts reuptake inhibition in a non-specific way. So, it is definitely one. It likely has other modes of action, also.
Lar
Posted by Phillipa on October 28, 2009, at 23:11:11
In reply to Re: Triple Reuptake Inhibitors. When? » Johnny32, posted by Larry Hoover on October 28, 2009, at 21:40:09
Lar would this work as a mild ad, antianxiety. Which could you combine how to get off the 50 luvox any suggestions and what to do about osteoporosis pretty bad. Thanks Phillipa
Posted by bulldog2 on October 29, 2009, at 15:33:25
In reply to Re: Triple Reuptake Inhibitors. When? » Larry Hoover, posted by Phillipa on October 28, 2009, at 23:11:11
> Lar would this work as a mild ad, antianxiety. Which could you combine how to get off the 50 luvox any suggestions and what to do about osteoporosis pretty bad. Thanks Phillipa
You cannot take sjw if you are on thyroid as it disrupts your med levels which can be dangerous. Also has been associated with cataracts.
Posted by Phillipa on October 29, 2009, at 21:32:09
In reply to Re: Triple Reuptake Inhibitors. When? » Phillipa, posted by bulldog2 on October 29, 2009, at 15:33:25
Bulldog it does? Got cataracts but small. But seriously didn't know it disrupted thyroid. Thanks. Phillipa
Posted by TenMan on October 29, 2009, at 21:39:30
In reply to Re: Triple Reuptake Inhibitors. When? » bulldog2, posted by Phillipa on October 29, 2009, at 21:32:09
You can take SJW with thyroid. The risk of interaction is theoretical. I know someone who combines synthroid with SJW is does fine. Just monitor how you feel and keep on your TSH with your doctor.
Posted by Phillipa on October 29, 2009, at 21:52:37
In reply to Re: Triple Reuptake Inhibitors. When?, posted by TenMan on October 29, 2009, at 21:39:30
Thanks Ten man. Love Phillipa
Posted by West on November 1, 2009, at 14:09:51
In reply to Re: Triple Reuptake Inhibitors. When?, posted by Johnny32 on October 28, 2009, at 17:19:30
> I'm afraid that combining multiple pills will increase side effects, that's why I was asking about triple uptake inhibitors (In trials, they had fewer side effects than SSRIs)
Would you happen to remember where you came across these trials. Even better, do you have any available links?
I would agree with you on the matter of problems arising from multiple medicine use. Currently those who require it, however, are left with little choice at a point in time when a sound knowledge of the underlying pathology of many affective disorders has yet to be elucidated.
This will provide a framework onto which a new generation of rationally designed drugs can be hinged. Psychopharmacology's relative infancy/primacy currently means that drug cocktails will be around for some time; as drugs counter the side effects of drugs or aim to target separate transmitters.
Worth noting too is the dominance towards selectivity over the past 25 years in drug design, mostly as a reaction to perceptions regarding the undesirability of existing multi-targeting drugs, the tricyclics.
I keep learning about MAOIs and multiple RIs that have existed since the 1970s but aren't in clinical use. Pyrizadol is a RIMA of 5-HT and NE in use since the 70s for depression in Russia.
Posted by West on November 1, 2009, at 15:59:55
In reply to Re: Triple Reuptake Inhibitors. When? Johnny, posted by West on November 1, 2009, at 14:09:51
Correction - primitiveness not primacy. Two quite different things.
This is the end of the thread.
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