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Dr. Bob is Robert Hsiung, MD,
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Posted by rovers95 on October 16, 2009, at 17:25:04
Having used amisulpride 25mg for 5 days I have had to quit due to increasing insomnia and irritability?
However, the mood improvement and increase in confidence over the first couple of days has made me feel that this is a med I'd want to give another try too?
Does anyone think amisulpride could be effective at a quarter tab (6.25mg) and perhaps, as others have suggested the side effects of this drug may dissipate over time?
I would be very grateful for any opinions!
Cheers
Rover
Posted by Brainbeard on October 18, 2009, at 14:44:48
In reply to amisulpride-how to avoid insomnia etc.?, posted by rovers95 on October 16, 2009, at 17:25:04
> Having used amisulpride 25mg for 5 days I have had to quit due to increasing insomnia and irritability?
>Weird. You take it in the morning, I presume? It never gave me insomnia, nor irritability. It does tend to boost my libido.
> Does anyone think amisulpride could be effective at a quarter tab (6.25mg) and perhaps, as others have suggested the side effects of this drug may dissipate over time?
Anything below 50mg seems to be effective when you're using amisulpride as a pro-dopaminergic drug (through blocking of presynaptic dopamine autoreceptors).
Not only may these side-effects dissipate, the impressive boost of the first day(s) will dissipate sooner rather than later. After that, amisulpride's effects will be more subtle.
In fact, to counter irritability and insomnia, you might be better off taking MORE than 25mg, perhaps even more than 50. If your dopamine is going overboard, amisulpride's higher dose D2-antagonism could quiet things down. At some point though, the benefits of presynaptic autoreceptor blockade will be lost. That point probably lies somewhere between 100 and 400mg.
According to an age old thread here, if one continues using the drug, its effects may seem to disappear for a couple of weeks, but after that an anxiolytic (anxiety relieving) and moodlifting effect will emerge. I haven't used the drug long-term on a daily basis myself, so I can't corroborate this.
Posted by rovers95 on October 19, 2009, at 14:29:55
In reply to Re: amisulpride-how to avoid insomnia etc.?, posted by Brainbeard on October 18, 2009, at 14:44:48
> > Having used amisulpride 25mg for 5 days I have had to quit due to increasing insomnia and irritability?
> >
>
> Weird. You take it in the morning, I presume? It never gave me insomnia, nor irritability. It does tend to boost my libido.
>
> > Does anyone think amisulpride could be effective at a quarter tab (6.25mg) and perhaps, as others have suggested the side effects of this drug may dissipate over time?
>
> Anything below 50mg seems to be effective when you're using amisulpride as a pro-dopaminergic drug (through blocking of presynaptic dopamine autoreceptors).
>
> Not only may these side-effects dissipate, the impressive boost of the first day(s) will dissipate sooner rather than later. After that, amisulpride's effects will be more subtle.
>
> In fact, to counter irritability and insomnia, you might be better off taking MORE than 25mg, perhaps even more than 50. If your dopamine is going overboard, amisulpride's higher dose D2-antagonism could quiet things down. At some point though, the benefits of presynaptic autoreceptor blockade will be lost. That point probably lies somewhere between 100 and 400mg.
>
> According to an age old thread here, if one continues using the drug, its effects may seem to disappear for a couple of weeks, but after that an anxiolytic (anxiety relieving) and moodlifting effect will emerge. I haven't used the drug long-term on a daily basis myself, so I can't corroborate this.
>Thanks for your advice....yeah i took it in the morning, its been nearly 5 days off it and my sleep still isnt yet back to "normal" and i still feel quite stressed out.
Bit scared to give a retrial but i think you could be right about going up rather than down, im also 6ft 6 and a reasonable build so perhaps i would need a larger dose!
But i think my ultimate goal would be to achieve downregulation of acetylcholine receptors (i believe mine are up-regulated) and improved dopamine through that!
Thanks again
Rover
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