Posted by Brainbeard on October 18, 2009, at 14:44:48
In reply to amisulpride-how to avoid insomnia etc.?, posted by rovers95 on October 16, 2009, at 17:25:04
> Having used amisulpride 25mg for 5 days I have had to quit due to increasing insomnia and irritability?
>Weird. You take it in the morning, I presume? It never gave me insomnia, nor irritability. It does tend to boost my libido.
> Does anyone think amisulpride could be effective at a quarter tab (6.25mg) and perhaps, as others have suggested the side effects of this drug may dissipate over time?
Anything below 50mg seems to be effective when you're using amisulpride as a pro-dopaminergic drug (through blocking of presynaptic dopamine autoreceptors).
Not only may these side-effects dissipate, the impressive boost of the first day(s) will dissipate sooner rather than later. After that, amisulpride's effects will be more subtle.
In fact, to counter irritability and insomnia, you might be better off taking MORE than 25mg, perhaps even more than 50. If your dopamine is going overboard, amisulpride's higher dose D2-antagonism could quiet things down. At some point though, the benefits of presynaptic autoreceptor blockade will be lost. That point probably lies somewhere between 100 and 400mg.
According to an age old thread here, if one continues using the drug, its effects may seem to disappear for a couple of weeks, but after that an anxiolytic (anxiety relieving) and moodlifting effect will emerge. I haven't used the drug long-term on a daily basis myself, so I can't corroborate this.
poster:Brainbeard
thread:921165
URL: http://www.dr-bob.org/babble/20091012/msgs/921422.html