![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 13 of 13. This is the beginning of the thread.
Posted by B2chica on August 13, 2008, at 8:37:31
its a long time before they're out (if they come out)i'm sure but one is in clinical trials at least right now.
there are three new meds being worked on right now. a new Class of AD called SNDRI (serotonin, norepinephrine DOPAMINE reuptake inhibitors)...just what 'I' am looking for.
the three i found are called:
tesofensine (currently in clnical trials)
brasofensine (under development)
and
GlaxoSmithKline's NS2359 (under development)however Tesofensine will most likely be marketed as a treatment for obesity (as reserached in phase II trials) now they are in phase III but it didn't say what for, if they've switched to look at potentially depression/bipolar or staying with appetite suppressant. it was originally researched for treatment of alzheimer's and parkinson's.
Brasofensine was researched for treatment of parkinson's and depression. the bad news is Phase II trials were conducted in 1996 and though was shown to be well tolerated the current status of this drug is unknown.
and i couldn't find any info on the GSK drug, so i don't know the status of this.
i'm writing about these meds incase anyone out there has more information about these meds.
i think the key to my issue is dopamine and if i could find a different drug that targets dopamine i'm thinking specificially D1 it could really help.
thanks
B2c
Posted by B2chica on August 13, 2008, at 14:09:15
In reply to will there be new meds...SNDRIs, posted by B2chica on August 13, 2008, at 8:37:31
Posted by better drugs on August 13, 2008, at 17:32:27
In reply to will there be new meds...SNDRIs, posted by B2chica on August 13, 2008, at 8:37:31
Brasofensine is no longer in trials. Its been closed down.
Tesofensine will start phase 3 trials in obesity around yearend
And NS2359 is currently in 2 big phase 2 trials for depression under the name gsk372475. Results is due in 6 month time
http://clinicaltrials.gov/ct2/results?term=gsk372475
Both NS2359 and Tesofensine is from the company Neurosearch. So you can find more here
Posted by Dade on August 13, 2008, at 21:09:51
In reply to will there be new meds...SNDRIs, posted by B2chica on August 13, 2008, at 8:37:31
"however Tesofensine will most likely be marketed as a treatment for obesity"
-any indication for ADD/HD, Narcolepsy?MMMM a 5ht, Dop, Norp reuptake inhibitor? any releasing affinity for these?
Sounds similar to Desoxyns (M-amphetamine) MOA, which is also indicated for obesity.
Posted by SLS on August 13, 2008, at 22:32:47
In reply to Re: will there be new meds...SNDRIs » B2chica, posted by better drugs on August 13, 2008, at 17:32:27
> Brasofensine is no longer in trials. Its been closed down.
>
> Tesofensine will start phase 3 trials in obesity around yearendAre these compounds related to nomifensine?
- Scott
Posted by B2chica on August 14, 2008, at 7:55:00
In reply to Re: will there be new meds...SNDRIs » B2chica, posted by better drugs on August 13, 2008, at 17:32:27
Posted by B2chica on August 14, 2008, at 8:16:42
In reply to ANYONE HEARD OF THESE?...SNDRIs (nm), posted by B2chica on August 13, 2008, at 14:09:15
here's a webpage i found a long time ago. not sure how accurate it still is. but its got a listing of drugs in the works for various disorders (depression, anxiety, sleep, bipolar...)
http://www.neurotransmitter.net/newdrugs.html
Posted by B2chica on August 14, 2008, at 8:35:25
In reply to Re: LIST of new upcomers, posted by B2chica on August 14, 2008, at 8:16:42
sorry for posting so much but i searched that website i just posted and realized that it is pretty old and doesn't seem to have been updated.
it shows mirapex as phase II which has been out for a while now, also a new one Valdoxan, which i think i've heard a few people here mention already
(5-HT2C antagonist, f-HT2B antagonist, melatonin M1/M2 receptor agonist)then there are two others that i would like to know more about if others have heard more of. they were specifically listed under bipolar. (psychosis) but also used for schizophrenia i believe.
zimaril (iloperidone)
(selective DA/NE/5-HT antagonist) at the time it was NDA submitted, which is one step away from being approved (though it would still take forever)the second is
Asenapine (ORG 5222)
5-HT2 antagonst, D2partial agonist
also NDA submitted
though this one looked a lot at schizophrenia and i think bipolar mania more so than depression.
http://clinicaltrials.gov/ct2/results?term=Asenapine
Posted by better drugs on August 14, 2008, at 9:01:25
In reply to Re: will there be new meds...SNDRIs » B2chica, posted by Dade on August 13, 2008, at 21:09:51
You can see the affinity here http://groups.google.dk/group/hochemicals/web/phenyltropanewiki
Tesofensine
dopamine 8nm
Noradrenaline 3,2nm
Serotonin 11nm
Posted by dcruik518 on August 16, 2008, at 15:10:31
In reply to Re: will there be new meds...SNDRIs, posted by better drugs on August 14, 2008, at 9:01:25
> You can see the affinity here http://groups.google.dk/group/hochemicals/web/phenyltropanewiki
>
> Tesofensine
> dopamine 8nm
> Noradrenaline 3,2nm
> Serotonin 11nm
>
I'm afraid that link is going to be way over most people's heads on here. What was your point? Are you recommending Tesofensine as an anti-depressant because it works on all three major neurotransmitters. What is the drug currently used for?
>
Posted by better drugs on August 19, 2008, at 13:14:49
In reply to Re: will there be new meds...SNDRIs, posted by dcruik518 on August 16, 2008, at 15:10:31
The link was just a reply to the question about affinity for Tesofensine.
Although there also should be some quiet compelling preclinical data there suggest using Tesofensine as an anti depressant, it will not be developed in that direction. The focus is on obesity and possible also type 2 diabetes. But it is still 3-4 years from the marked.
NS2359/GSK372475 on the other hand is developed for depression. And it works more or less in a similar way as Tesofensine by altering the 3 neurotransmitters dopamine, serotonin and noradrenaline. The affinity for NS2359 is
Dopamine 8nm
Noradrenaline 0,6nm
Serotonin 5nmGlaxoSmithKline plans to start several large phase 3 depression trials with NS2359/GSK372475 in the middle of 09. And they think that this new mechanism will be the next new big anti depression drug class and thereby overtake the SSRI class. Only time will show if thats true.
Posted by B2chica on August 20, 2008, at 8:02:06
In reply to Re: will there be new meds...SNDRIs, posted by better drugs on August 19, 2008, at 13:14:49
> GlaxoSmithKline plans to start several large phase 3 depression trials with NS2359/GSK372475 in the middle of 09.
>thanks i was looking for this info.
if all runs well, when do you think theyll try to get it on the market? 2010/11? or lateri really have my hopes for this drug since it has more effect with dopamine and with me this seems to be key.
and maybe, just maybe with this in mind, i can hang in there a while longer.thanks
b2c.
Posted by aussie_jon on August 22, 2008, at 22:40:05
In reply to Re: will there be new meds...SNDRIs, posted by better drugs on August 19, 2008, at 13:14:49
We have a SNDRI already, by taking Welbutrin with an SSRI or Effexor
This is the end of the thread.
Psycho-Babble Medication | Extras | FAQ
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.org
Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.