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Dr. Bob is Robert Hsiung, MD,
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Posted by Phillipa on January 6, 2008, at 20:01:40
In reply to Re: When meds don't work » johnj, posted by SteelyDan on January 6, 2008, at 19:13:15
Thought low dose was sedating and high dose stimulating? What is low dose Thanks Phillipa
Posted by SteelyDan on January 6, 2008, at 20:11:52
In reply to Re: When meds don't work » SteelyDan, posted by Phillipa on January 6, 2008, at 20:01:40
> Thought low dose was sedating and high dose stimulating? What is low dose Thanks Phillipa
Yes, low dose 100-200mgs. is sedating...increasing to 300-600mgs. is somewhat stimulating, but in a nice smooth way, if that makes sence?
Posted by johnj on January 6, 2008, at 20:23:53
In reply to Re: When meds don't work, posted by bleauberry on January 6, 2008, at 18:12:10
"Have you had a full thyroid workup? TSH, free T3, free T4, and thyroid antibodies? If not, you need one to rule it out or confirm."
Everything checks out.
How about a 24 hour 4 sample saliva cortisol test? That would be very informative in which way to go with treatment.
"Right now you need FAST relief. I mean, family, work, wife. Wife. Very important. The more you suffer, the more she doesn't understand (and she never will so don't push that) the more you guys drift apart. Not cool. You need relief now, and a longer term solution after that."
We had a long talk today. Thank you. My ocd goes haywire when I can't fall asleep and I make things out to be worse than it really is.
"One thing that can bring both immediate and longterm control of what you are feeling is...Zyprexa. You want to bring all that fast furious worry and OCD down to a soft cushion in a mere 2 hours? Zyprexa. I know your symptoms. Been there. I know Zyprexa. Been there."
Seroqeul gave me akathisia would zyprexa too. Anti-P scare me to be honest.
"Maybe it is a week or a month until you can see the doc. What until then? The healtfood store. Get a tincture bottle of Passionflower and Skullcap, and maybe Valerian. Try passionflower first, add the others if you want. They can really take the edge off in just an hour or so. They can be your ticket to buy some time and not lose ground. They have saved me several times when I did not have pharmaceuticals handy."
THANK YOU, great suggestions I am going tomorrow.
"After so many years of mood stabilization control, it may take just as many years to fully recover, if at all. I wonder, why not lithium again? You should do a google search on Magnesium and Taurine for anxiety and bipolar. Those are often effective longterm cures, and not surprisingly the actual root cause all along. Your symptoms are hard to pinpoint in terms of cause, but they sure fit the low serotonin profile."
I don't feel too well on magnesium, but i have some taurine I have never tried. I will break it out.
"5htp in 10mg to 25mg doses for a few days would be a telling test"
What do you mean telling?
"Depakote or lithium takes weeks to be therapeutic, and months to actually cause the brain changes needed. A short trial of a mood stabilizer tells you nothing, other than whether maybe you can handle a starting dose or not. Same with the SSRIs. If anxiety was worse, odds are it would have resolved in 6 to 10 weeks, but your doc should have given you a bandaid drug to get that far while waiting."
Depakote is too depressionogenic. I get the fever chills that affects sleep, it was really odd. That said, maybe I am giving up too soon? I was taking 250. If the chills were not so bad I could probably handle it. I think that kept me from sleeping.
Lithium didn't make me feel well and kind of reved me up a bit. The doctor wants to try lamictal. I wonder about tegretol?
"Based on your symptoms, I do believe in the gut that a longterm solution is found in one of these things...Zyprexa, lithium, depakote, magnesium, taurine, or any combination of 2 or 3 of them. For short term immediate relief, passionflower, skullcap, valerian, and of course the star of the show zyprexa. "
What about lamactil, lyrica, neurotnin? I would like something to help sleep that doesn't make me feel depressed.
The thing I know NOTHING about is what do bipolars do for the sleep issues? Can they take small doses of AD's? I was thinking something to slow me down and then some type of AD adjunct for sleep, etc., like anafranil for it's ocd help and anxiety help.
Thank you for such a long response, I appreciate it.
johnj
Posted by johnj on January 6, 2008, at 20:25:03
In reply to Re: When meds don't work » johnj, posted by SteelyDan on January 6, 2008, at 19:13:15
What have you been taking? What is your diagnosis? I was thinking of lyrica
Posted by SteelyDan on January 6, 2008, at 20:29:45
In reply to Re: When meds don't work » SteelyDan, posted by johnj on January 6, 2008, at 20:25:03
> What have you been taking? What is your diagnosis? I was thinking of lyrica
Chronic TR Atypical depression, and GAD. I would highly recommend you give it a try, be patient with it because at starting dose it will sedate you, as you ramp up it's almost euphoric at the 500-600 range. Good luck!
Posted by Phillipa on January 6, 2008, at 20:47:00
In reply to Re: When meds don't work » johnj, posted by SteelyDan on January 6, 2008, at 20:29:45
Thank-you Dan. Phillipa
Posted by bleauberry on January 8, 2008, at 19:19:15
In reply to Re: When meds don't work » bleauberry, posted by johnj on January 6, 2008, at 20:23:53
> Seroqeul gave me akathisia would zyprexa too. Anti-P scare me to be honest.
Yeah I know. Actually, all these drugs scare me. I was on zyprexa 8 years. Even though it is a powerful drug, it felt friendlier than all the rest, if that makes any sense. Seroquel gave me some akathisia too, but zyprexa never did.
> I don't feel too well on magnesium, but i have some taurine I have never tried. I will break it out.Yeah, magnesium bums me out bigtime. I can't take it. Instant depression worsener for me, though it is very calming. Taurine I liked, but only when combined with Tyrosine. Unpreictable though. I think these supps are good for longterm health and healing, but not as powerful for rightnow relief.
>
> "5htp in 10mg to 25mg doses for a few days would be a telling test"
>
> What do you mean telling?Well, if you have a low serotonin situation, getting the serotonin up immediately will show things to you. The first 3 days or so are adjustment periods and need to be ignored. After that though you can tell what is happening. One of several things will happen...you will feel calmer and better; you will feel calmer and more depressed; you will feel great all around; you will feel more anxious and irritable; you will feel nothing. It definitely calms me down, but gets a bit depressing too, probably because I need something else besides just serotonin alone. Sleep is much better, deep and yet with vivid dreams.
The herbs can help but please understand I am not endorsing them as longterm cures. Some people might. I see them more as stepping stone crutches to get through rough moments, to get from here to there, all the while knowing something else needs to be done longterm. No need to suffer the entire duration though. There is an herb that you can rely on kind of like a spare tire for a flat.
Posted by Phillipa on January 8, 2008, at 20:38:24
In reply to Re: When meds don't work, posted by bleauberry on January 8, 2008, at 19:19:15
Wait have a female problem that makes pooping hard to do so take extra magnesium not good? Could it affect anxiety? Thought it was calming? Phillipa
Posted by tecknohed on January 8, 2008, at 21:33:11
In reply to Re: When meds don't work » bleauberry, posted by Phillipa on January 8, 2008, at 20:38:24
> Wait have a female problem that makes pooping hard to do so take extra magnesium not good? Could it affect anxiety? Thought it was calming? Phillipa
For constipation I always use lactulose solution. Its the mildest yet most effective laxative I've used. Though it can take a week to settle. It tastes nice too - all it is is an undigestable sugar. Senna does nothing for me & fibre gels make things worse.
How much magnesium are you taking & what form? Even though its essential & the RDA/RDI is 3-400mg I cant tolerate much more than 100mg of Mag citrate per day. Plus, I actually find anything that slows me down actually INCREASES my anxiety. Of course the sedative effects of my Klonopin have worn off a long time ago. Mag seems too keep that calming/sedating effect even over time. In fact it seemed to actually increase the longer I took 300mg.
teck
Posted by Phillipa on January 8, 2008, at 23:44:32
In reply to Re: When meds don't work » Phillipa, posted by tecknohed on January 8, 2008, at 21:33:11
Teck taking less than l00mg with my calcium/magnesium l:2 ratio as should be. I stay in a state of almost diarrhea can't believe we're talking about this. Love Phillipa
Posted by tecknohed on January 9, 2008, at 8:38:29
In reply to Re: When meds don't work » tecknohed, posted by Phillipa on January 8, 2008, at 23:44:32
> Teck taking less than l00mg with my calcium/magnesium l:2 ratio as should be. I stay in a state of almost diarrhea can't believe we're talking about this. Love Phillipa
What form of mag are you taking? Some poorly absorbable forms go strait through you and act as laxatives, hence why some magnesium salts are sold as laxatives.
Posted by Phillipa on January 9, 2008, at 19:45:19
In reply to Re: When meds don't work » Phillipa, posted by tecknohed on January 9, 2008, at 8:38:29
Tech mag citrate. Phillipa
Posted by tecknohed on January 10, 2008, at 7:51:17
In reply to Re: When meds don't work » tecknohed, posted by Phillipa on January 9, 2008, at 19:45:19
> Tech mag citrate. Phillipa
Same as me. Do you really need it? Make sure you're not drinking tea with it. Better laxatives to keep you regular without diarheo :)
Posted by Phillipa on January 10, 2008, at 22:47:21
In reply to Re: When meds don't work » Phillipa, posted by tecknohed on January 10, 2008, at 7:51:17
Thanks Teck no I take it at night before bed. Used to take an herbal laxative. Love Phillipa
Posted by bissie66 on January 18, 2008, at 14:43:29
In reply to Re: When meds don't work, posted by bleauberry on January 6, 2008, at 18:12:10
Same with the SSRIs. If anxiety was worse, odds are it would have resolved in 6 to 10 weeks, but your doc should have given you a bandaid drug to get that far while waiting.
>
I've been browsing and reading on anxiety bc I've been experiencing some lately. So you think anxiety really gets better on SSRI's after 6-10 weeks? I started Zoloft recently but have backed away bc of anxiety, and yet it helped me SO much in the past (with depression AND anxiety).Thanks!
Posted by deniseuk190466 on January 21, 2008, at 6:42:05
In reply to Re: When meds don't work » bleauberry, posted by bissie66 on January 18, 2008, at 14:43:29
Hi,
The first antidepressant medication I ever took was at the age of 24, it was a tricyclic and after 24 hours I felt so much better, no anxiety, no depression, I felt like I had died and gone to heaven.
Then later in my 20s I was switched to Seroxat, again no anxiety and they worked well within 4 days. Infact I wondered at the time if I felt too good.
Then I came off them at the age of around 31. Four years later the depression resurfaced and I tried many of the SSRIs, they all increased the anxiety, suicidal feelings and never ever really worked the same again.
I really don't know why that happened and I'd give anything to know because since the age of 35 my life has never been the same.
Denise
Posted by tecknohed on January 21, 2008, at 9:32:11
In reply to To Bissie66, posted by deniseuk190466 on January 21, 2008, at 6:42:05
> Hi,
>
> The first antidepressant medication I ever took was at the age of 24, it was a tricyclic and after 24 hours I felt so much better, no anxiety, no depression, I felt like I had died and gone to heaven.
>
> Then later in my 20s I was switched to Seroxat, again no anxiety and they worked well within 4 days. Infact I wondered at the time if I felt too good.
>
> Then I came off them at the age of around 31. Four years later the depression resurfaced and I tried many of the SSRIs, they all increased the anxiety, suicidal feelings and never ever really worked the same again.
>
> I really don't know why that happened and I'd give anything to know because since the age of 35 my life has never been the same.
>
>
>
> DeniseHormone issues I suspect. They change with age. Have you had them tested (esp Thyroid, Adrenal & sex hormones)? That might be a worthy next step.
teck
Posted by deniseuk190466 on January 21, 2008, at 14:41:08
In reply to Re: To Bissie66 » deniseuk190466, posted by tecknohed on January 21, 2008, at 9:32:11
Hi,
Do you think it is really that simple. I've had all of the tests and they all came back ok, apart from my oestrogen being a bit low that was all.
My theory is that in time and with age your brain just gets more resistant.
Thanks for the advice anyway......Denise
Posted by tecknohed on January 21, 2008, at 19:42:55
In reply to tecknohed, posted by deniseuk190466 on January 21, 2008, at 14:41:08
> Hi,
>
> Do you think it is really that simple. I've had all of the tests and they all came back ok, apart from my oestrogen being a bit low that was all.
>
> My theory is that in time and with age your brain just gets more resistant.
>
> Thanks for the advice anyway......DeniseObviously I was wrong, sorry. I didn't know you've already had such tests but it obviously isn't hormones (or at least the ones I mentioned). For anyone in your position who hasn't had those tests I think its still a good idea to have them to rule it out. Are you on any HRT for your slightly low oestrogen?
Mind you some people do well adding hormones like Thyroid to the mix even if thier levels appear 'normal'.But you're still young anyway - 35-40 isn't old, nor is 50! :) I guess we're all just as old as we feel. I felt OLD in my late teens due to untreated symptoms! Felt like I'd go to sleep & never wake up - every night. Very achey & slowed down. Bags under my eyes. Etc, etc...
I guess you'll just have to keep trying different meds &/or treat your symptoms aggressively. I myself am taking 50mg Marplan + 3mg Klonopin & will soon be adding 300mg Wellbutrin. I also take a whole bundle of supplements (nootropics, herbs, oils, vits & mins) to help boost my meds & control the side effects, & boost my immune system too.
Hope you find some freedome soon! :)
teck
Posted by Phillipa on January 21, 2008, at 20:57:41
In reply to Re: tecknohed » deniseuk190466, posted by tecknohed on January 21, 2008, at 19:42:55
Well you only made it to 50!!!!! Waaaaah. Love Phillipa
Posted by tecknohed on January 21, 2008, at 21:19:22
In reply to Re: tecknohed » tecknohed, posted by Phillipa on January 21, 2008, at 20:57:41
> Well you only made it to 50!!!!! Waaaaah. Love Phillipa
Oops! But you know what I meant ;)
Kev xoxo
Posted by bissie66 on January 22, 2008, at 11:57:19
In reply to To Bissie66, posted by deniseuk190466 on January 21, 2008, at 6:42:05
Thank you for sharing your experience. I can relate to the horrible frustration of medications no longer working. It's hard to describe that disappointment. Just this morning my pdoc decided he's gonna take the approach of switching meds right when they poop out on me (cuz it seems to happen quick lately). We're trying Cymbalta next.
> Hi,
>
> The first antidepressant medication I ever took was at the age of 24, it was a tricyclic and after 24 hours I felt so much better, no anxiety, no depression, I felt like I had died and gone to heaven.
>
> Then later in my 20s I was switched to Seroxat, again no anxiety and they worked well within 4 days. Infact I wondered at the time if I felt too good.
>
> Then I came off them at the age of around 31. Four years later the depression resurfaced and I tried many of the SSRIs, they all increased the anxiety, suicidal feelings and never ever really worked the same again.
>
> I really don't know why that happened and I'd give anything to know because since the age of 35 my life has never been the same.
>
>
>
> Denise
Posted by bissie66 on January 22, 2008, at 12:00:51
In reply to tecknohed, posted by deniseuk190466 on January 21, 2008, at 14:41:08
I have long felt like there is a hormonal piece to it, because my illness got much worse with each pregnancy. My 3rd pregnancy made me bipolar, I swear to God.
Just look at postpartum depression if you want proof for what hormones can do to you! (Not to mention PMS, menopause.) But I'm preaching to the choir.
Posted by Phillipa on January 22, 2008, at 19:21:55
In reply to Re: tecknohed, posted by bissie66 on January 22, 2008, at 12:00:51
Menopause was when all the horrible stuff happened for me the thyroid host of other stuff and look at Brooke Shields. She opened to door for a lot of people I think. Love Phillipa
Posted by deniseuk190466 on February 6, 2008, at 15:47:06
In reply to Re: tecknohed » deniseuk190466, posted by tecknohed on January 21, 2008, at 19:42:55
Tecknohed,
I've just seen your response to me and just want to say thanks for trying to suggest something even if I'm too low really to think anything will ever bring about a true remission.
I've been off all meds now since late December because I keep toying with the idea of participating in a Ketamine trial in the States. To participate in the trial you have to be off medication for at least two weeks. As I'm off it I think I should perhaps just stay off it until I go on the trial but then again I don't even know if I'm going to go on the trial. I don't know what I'm doing.
All I know is that I just feel continually low every day without medication and I am trying herbal supplements, thyanine, folic acid, taurine, valarian, Rhodiala Rhosea and others but they are not helping. I'm also having Therapy which doesn't seem to be helping either.
Every day I feel as though I wish I were dead.
I know I need to get back on medication but then I'm not sure about whether to go on this Ketamine trial, I'm not sure about anything apart from the fact that I'd just love to lie down and never ever wake up.
I haven't tried HRT although I went to see a specialist who prescribed oestrogen patches. I never used them but I have them in my drawer and I think I'll try them tonight.
I just want total remission from this depression. Antidepressants and Zyprexa now and again does help but they just don't work the same as they used to.
Sorry, started rambling again, thanks again for being kind enough to make suggestions.
Denise
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