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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 11 of 11. This is the beginning of the thread.
Posted by UgottaHaveHope on December 25, 2007, at 3:13:44
I have heard from a good source that there is a study going on somewhere in the USA on a new MAOI drug. The way this person who is one of the pdocs overseeing the study described it, the med was like "Nardil without the Nardil side effects." The person said the study was going very well, but did not indicate anything else, such as impending FDA approval. I'll have to find out more in the near future.
Anyone else heard about this?
Anyway, this is why you should NEVER give up hope, folks! As bad as you and me have felt in past or currently feel, there are always different medicinal combinations you can try, and NEW MEDS coming out. Never, ever, never, ever give up hope.
Merry Christmas. Michael
Posted by Phillipa on December 25, 2007, at 12:26:44
In reply to A new MAOI being tested (Nardil w/o side effects), posted by UgottaHaveHope on December 25, 2007, at 3:13:44
Merry Christmas Michael wouldn't that be wonderful if it's right. Love to you Phillipa
Posted by Netch on December 25, 2007, at 13:06:03
In reply to A new MAOI being tested (Nardil w/o side effects), posted by UgottaHaveHope on December 25, 2007, at 3:13:44
If you are talking about Tyrima, a reversible inhibitor of MAO-A (RIMA); phase I studies has been done this year. Two more to go.
/Netch
Posted by ace on December 25, 2007, at 23:06:42
In reply to A new MAOI being tested (Nardil w/o side effects), posted by UgottaHaveHope on December 25, 2007, at 3:13:44
> I have heard from a good source that there is a study going on somewhere in the USA on a new MAOI drug. The way this person who is one of the pdocs overseeing the study described it, the med was like "Nardil without the Nardil side effects." The person said the study was going very well, but did not indicate anything else, such as impending FDA approval. I'll have to find out more in the near future.
>
> Anyone else heard about this?I find it hard to concieve of a compound which is so similiar to Nardil without the s/effects. In a way it it is not logical, by virtue of the fact that such a similiar compound would, by perforce, have to have an extremely similiar mode of action, and thus effect the same organs in similar ways. But who knows!? All i can say it is great to see people thinking this way.
Also who is funding the study? Unless some Nardil freaks like myself are, I can't see who would put the money in.
> Anyway, this is why you should NEVER give up hope, folks! As bad as you and me have felt in past or currently feel, there are always different medicinal combinations you can try, and NEW MEDS coming out. Never, ever, never, ever give up hope.I agree with this 1000000000000000000.........%!!!!!!!!!!!!!!!
Even when in a state of hatatonic depression in the past (not too many, thank goodness) I try always to see a white light. It's so much easier said than done when you feel so depressed but. But somehow I feel it is best to cling to that one special vector of light, even when all is dark, bleak, and that suicide seems a solution.
Soldier on Brave souls!
Merry Xmas Michael and everyone!!!!!!!!
Ace:)
> Merry Christmas. Michael
Posted by UgottaHaveHope on December 26, 2007, at 3:01:25
In reply to Re: A new MAOI being tested (Nardil w/o side effec, posted by ace on December 25, 2007, at 23:06:42
Ace, the person who told me was also one of the co-founders of Emsam, which apparently is not going to make it. However, with this pdoc involved, I don't see funding being any problem.
Anyways, surely this med will be different enough from Nardil to warrant its own patent, hence a worthy investment for the pharm industry. The pdoc said it was like "Nardil without all the Nardil side effects." That was probably explaining it in laymen's terms where I would understand. I'm sure it has a lot of differences from Nardil (at least enough to warrant an FDA patent :)
But it is a MAOI. And it is something new. And being a big believer in MAOIs, it does excite me. I hope they continue to dedicate funds and research to MAOIs because they help so many. And it's about time. The pharm industry never should've gotten off the MAOI bandwagon since it has worked so well for so many for so long.
I'll try to find out more on my next visit. Hap New Year.
Posted by tecknohed on December 26, 2007, at 20:02:49
In reply to Re: A new MAOI being tested (Nardil w/o side effects), posted by Netch on December 25, 2007, at 13:06:03
> If you are talking about Tyrima, a reversible inhibitor of MAO-A (RIMA); phase I studies has been done this year. Two more to go.
>
> /Netch
>
> http://www.medicalnewstoday.com/articles/61967.phpIf this 'Nardil-like' drug is the RIMA mentioned above then how can it be like Nardil? Nardil inhibits MAO-A & B. That means EXTRA dopamine. Bit like a RIMA plus an MAO-B inhibitor. And where would the GABA effects come from?
Maybe its not the drug mentioned above?
Still, always nice to see new promissing meds. Unless it's just gonna be another 'me too' RIMA, like most of the SSRIs seem to be.
Oops, that was a gloomy reply, sorry!
Posted by clipper40 on December 27, 2007, at 2:41:18
In reply to Re: Who is funding this study? lol » ace, posted by UgottaHaveHope on December 26, 2007, at 3:01:25
So it won't be on the market much longer? That would be awful!
Posted by amigan on December 27, 2007, at 16:37:21
In reply to Re: A new MAOI being tested (Nardil w/o side effec, posted by tecknohed on December 26, 2007, at 20:02:49
> > If you are talking about Tyrima, a reversible inhibitor of MAO-A (RIMA); phase I studies has been done this year. Two more to go.
> >
> > /Netch
> >
> > http://www.medicalnewstoday.com/articles/61967.php
>
> If this 'Nardil-like' drug is the RIMA mentioned above then how can it be like Nardil? Nardil inhibits MAO-A & B. That means EXTRA dopamine. Bit like a RIMA plus an MAO-B inhibitor. And where would the GABA effects come from?How about: Benzodiazepine+moclobemide+selegiline? (GABA+RIMA+MAO-B) Behold the new safe Nardil! :-p
Posted by former trx resistant on December 30, 2007, at 3:59:45
In reply to Re: A new MAOI being tested (Nardil w/o side effec » tecknohed, posted by amigan on December 27, 2007, at 16:37:21
Ok, I'm now slightly SCARED! Don't take my EMSAM away. I was a pharmaceutical rep in late 1970's so I know you can't always believed the Drug company. But I called Bristol and they said no plans, doing fine... but 6mg really seems to produce same benefits as 9 or 12 in most individuals. They're making enough money, maybe those of us on EMSAM could offer our life changing stories. I would go public to save this drug. I'm going to write them next week. Heck, I'll detail all the docs in my area for free patches!
Posted by tecknohed on December 31, 2007, at 20:52:32
In reply to Re: A new MAOI being tested (Nardil w/o side effec » tecknohed, posted by amigan on December 27, 2007, at 16:37:21
> > If this 'Nardil-like' drug is the RIMA mentioned above then how can it be like Nardil? Nardil inhibits MAO-A & B. That means EXTRA dopamine. Bit like a RIMA plus an MAO-B inhibitor. And where would the GABA effects come from?
>
> How about: Benzodiazepine+moclobemide+selegiline? (GABA+RIMA+MAO-B) Behold the new safe Nardil! :-pSounds nice! However, how many doctors would willingly prescribe 2 MAOIs, even if the do work on different MAOs? None that I know of, even though in theory it sounds safe.
Posted by sdb on January 1, 2008, at 21:01:44
In reply to Re: A new MAOI being tested (Nardil w/o side effects), posted by Netch on December 25, 2007, at 13:06:03
> If you are talking about Tyrima, a reversible inhibitor of MAO-A (RIMA); phase I studies has been done this year. Two more to go.
>
> /Netch
>
> http://www.medicalnewstoday.com/articles/61967.php
This is the end of the thread.
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