![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 8 of 8. This is the beginning of the thread.
Posted by bipolarspectrum1 on September 3, 2007, at 14:06:08
Hey Link,
wondering what happened to ur foray into protein kinase inhibition.. http://large-group.org/babble/20030723/msgs/245266.htmlI tried tamoxifen and had an interesting response to it.. I'm wondering what you thought of quercetin?? I need something to help with my mixed mania...
bps
Posted by linkadge on September 3, 2007, at 15:02:33
In reply to Linkage, posted by bipolarspectrum1 on September 3, 2007, at 14:06:08
What was your responce to tamoxafin ?
A number of antimanic agents will supress PKC. Reducing the activity of PKC-epsilon in particular, will enhance the brains responce to GABA.
Quercetin does have a calming effect. It is a strong PKC inhibitor.
Quercetin is also a MAOI, and a COMT inhibitor, which may exaserbate some mania for some people.
I have thought of quercetin as almost like a mood stabilizer. It is active as an antidepressant in animal models of depression, it is neuroprotective.I know that there are similar cellular effects of other flavanoids. I think a number of citrus bioflavanoids can reduce PKC activity.
Green tea also reduces PKC. I would speculate there to be a synergy between the PKC inibition, and the GABA effect of theanine. Also, green tea is an acetycholinsterase inhibitor, which can help mania for some people.
But, green tea is also a COMT inhibitor which may make some mania worse. Also theanine is a NMDA antagonist, which may agrevate some psychotic like states.
Hard to say what the net effect is.
I find green tea really helps take the edge off.
Linkadge
Posted by Phillipa on September 3, 2007, at 18:14:06
In reply to Re: Linkage, posted by linkadge on September 3, 2007, at 15:02:33
Link the only thing I drink is green tea. Does it help anxiety also? Phillipa
Posted by linkadge on September 3, 2007, at 19:50:21
In reply to Re: Linkage » linkadge, posted by Phillipa on September 3, 2007, at 18:14:06
Yes, green tea can help anxiety.
Linkadge
Posted by Phillipa on September 3, 2007, at 22:17:13
In reply to Re: Linkage, posted by linkadge on September 3, 2007, at 19:50:21
Link thanks so much as I love to drink it. So the caffeine in it is negligable? Love Phillipa
Posted by Dragon Black on September 3, 2007, at 23:28:23
In reply to Re: Linkage » linkadge, posted by Phillipa on September 3, 2007, at 22:17:13
No, there's caffeine, but it's stimulating effect is generally cancelled out by the L-theanine, which is anxiolytic.
> Link thanks so much as I love to drink it. So the caffeine in it is negligable? Love Phillipa
Posted by Phillipa on September 4, 2007, at 19:27:55
In reply to Re: Linkage, posted by Dragon Black on September 3, 2007, at 23:28:23
Thank-you both. Phillipa
Posted by finelinebob on September 7, 2007, at 11:10:06
In reply to Re: Linkage, posted by Phillipa on September 4, 2007, at 19:27:55
Sorry about hijaking a thread here, but saw the name of the poster (bipolarspectrum1) and here I was thinking, as a Babblelander old f*rt, that I was like the only one talking about this.
That'll teach me for staying away too long. Pleased to meet ya, fellow BSD'er!
flb
This is the end of the thread.
Psycho-Babble Medication | Extras | FAQ
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.org
Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.