Posted by linkadge on September 3, 2007, at 15:02:33
In reply to Linkage, posted by bipolarspectrum1 on September 3, 2007, at 14:06:08
What was your responce to tamoxafin ?
A number of antimanic agents will supress PKC. Reducing the activity of PKC-epsilon in particular, will enhance the brains responce to GABA.
Quercetin does have a calming effect. It is a strong PKC inhibitor.
Quercetin is also a MAOI, and a COMT inhibitor, which may exaserbate some mania for some people.
I have thought of quercetin as almost like a mood stabilizer. It is active as an antidepressant in animal models of depression, it is neuroprotective.I know that there are similar cellular effects of other flavanoids. I think a number of citrus bioflavanoids can reduce PKC activity.
Green tea also reduces PKC. I would speculate there to be a synergy between the PKC inibition, and the GABA effect of theanine. Also, green tea is an acetycholinsterase inhibitor, which can help mania for some people.
But, green tea is also a COMT inhibitor which may make some mania worse. Also theanine is a NMDA antagonist, which may agrevate some psychotic like states.
Hard to say what the net effect is.
I find green tea really helps take the edge off.
Linkadge
poster:linkadge
thread:780565
URL: http://www.dr-bob.org/babble/20070831/msgs/780578.html