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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 13 of 13. This is the beginning of the thread.
Posted by jealibeanz on August 26, 2006, at 22:29:16
Why do most sources state that MAOI's cause weight gain? Is this because most of the MAOI's, until now, prescribed in the US were MAOI-A's? Those are more likely to cause weight gain than MAOI-B's, right?
Seriously, there is wayyy too much conflicting, hidden, and misinformation. Oh yeah, by the way, every (even copywrite 2006) text you'll ever see mentioning an SSRI says no weight gain, I've got about 5 right here that claim this to be true. I could understand reporting that in 1990, but come on, in 2006, we all know better.
It's not always because the patient become happier and decides to eat. (Who decides to over-eat continiuously to the point of becoming overweight or obese?) Sometimes, it's just the drug!
Well, anyway, my real question is, do MAOI-A's cause weight gain, while MAOI-B's do not? Are there any MAOI-B's available in the US, beside EMSAM at a lose dose?
Posted by willyee on August 26, 2006, at 23:42:14
In reply to MAOI's + Weight Gain, posted by jealibeanz on August 26, 2006, at 22:29:16
> Why do most sources state that MAOI's cause weight gain? Is this because most of the MAOI's, until now, prescribed in the US were MAOI-A's? Those are more likely to cause weight gain than MAOI-B's, right?
>
> Seriously, there is wayyy too much conflicting, hidden, and misinformation. Oh yeah, by the way, every (even copywrite 2006) text you'll ever see mentioning an SSRI says no weight gain, I've got about 5 right here that claim this to be true. I could understand reporting that in 1990, but come on, in 2006, we all know better.
>
> It's not always because the patient become happier and decides to eat. (Who decides to over-eat continiuously to the point of becoming overweight or obese?) Sometimes, it's just the drug!
>
> Well, anyway, my real question is, do MAOI-A's cause weight gain, while MAOI-B's do not? Are there any MAOI-B's available in the US, beside EMSAM at a lose dose?Well obviously im on parnate,and while i absolutly notice a DECREASE in actual appetite,my overall body mass has increased so much i literaly grew out of my sneakers,my parents think seriously im on some form of steroids,i lift weights so although the mass seems to be neither fat,nor pure ripped muslce,it is a general mass,i went from 180 to 25,my entire body widened,in all honesty im glad i do lift im also glad i have a lil hieght on me,i can imagine the struggle of someone who simply doesent live that lifstyle,it must be totaly confusing to see ur appetite drop yet see this mass appear that doesent seem to respond to tradional weight loss methods.
Posted by Racer on August 27, 2006, at 0:21:47
In reply to MAOI's + Weight Gain, posted by jealibeanz on August 26, 2006, at 22:29:16
>
> It's not always because the patient become happier and decides to eat. (Who decides to over-eat continiuously to the point of becoming overweight or obese?) Sometimes, it's just the drug!
>I can't answer the question about MAOIs, but I wanted to tell you something I heard from a T a few years ago:
"These medications don't make you gain weight. They're like birth control pills -- you gain weight because when you take them, you eat more and don't exercise."
Not a very good T, as you can imagine. {shakes head} Kinda like the pdoc who told me that SSRIs only cause sexual side effects for men. Not for women.
HAHAHAHAHAHAHAHAHA!!!
Not.
It's amazing how much disinformation is out there about these things. You're right -- there's no excuse for anything to say that SSRIs don't cause weight gain. Ugh. I can't talk about this one anymore. It's An Issue for me, ya know?
Posted by jealibeanz on August 27, 2006, at 2:57:41
In reply to Re: MAOI's + Weight Gain, posted by willyee on August 26, 2006, at 23:42:14
sounds like me and effexor :)
Posted by jealibeanz on August 27, 2006, at 3:03:51
In reply to Re: MAOI's + Weight Gain » jealibeanz, posted by Racer on August 27, 2006, at 0:21:47
I think I'm right about the MAOI-B's. Since they have no involvement in serotonin, which seems to be the main culprit in me for weight gain, it shouuuuld be neutral, but who knows...
It's understandable that the doctors don't know why it happens or how to predict who will or won't gain. It's another thing entirely to ignore that it happens and make the patient feel like a circus freak because the literature says the SSRI's cause weight loss!
Hahaha, birth control... oh yeah there's another fun one. I'm actually lucky enough not to be in the group who gains, but it's clear that some do. It's obvious why... you're playing with female hormones! Low dose or not, one of their main purposes is to promote fat accumulation (it's tricking the body into thinking it's pregnant, what should we expect?)
Posted by llrrrpp on August 27, 2006, at 11:29:43
In reply to Re: MAOI's + Weight Gain, posted by willyee on August 26, 2006, at 23:42:14
geez willee,
I wouldn't want to run into you on a bad day!! you sound pretty strong!-ll
Posted by Phillipa on August 27, 2006, at 17:48:19
In reply to Re: MAOI's + Weight Gain, posted by willyee on August 26, 2006, at 23:42:14
Willyee post you're website and let them see your muscles. Love Phillipa
Posted by willyee on August 27, 2006, at 22:06:56
In reply to Re: MAOI's + Weight Gain » willyee, posted by Phillipa on August 27, 2006, at 17:48:19
> Willyee post you're website and let them see your muscles. Love Phillipa
Ha i dont feel comfortable having anyone see my sight i dont wanna direct people anymore to what might offend them,i really dont know any longer,besides,this is the net,its not hard to find anything on it,unfortunatly having a big mouth im all over the internet in archives and such.
Posted by jedi on August 28, 2006, at 4:42:05
In reply to MAOI's + Weight Gain, posted by jealibeanz on August 26, 2006, at 22:29:16
...
> Well, anyway, my real question is, do MAOI-A's cause weight gain, while MAOI-B's do not? Are there any MAOI-B's available in the US, beside EMSAM at a lose dose?
...
Hi,
Parnate and Nardil, the most popular irreversible MAOIs in the US, affect both MAO-A and MAO-B. Selegiline in low doses only affects MAO-B, at higher doses it affects both. I'm not sure about the lowest dose of EMSAM, I haven't studied it enough. Nardil is noted for weight gain, in my case massive weight gain. Parnate is more stimulating and usually causes some weight loss. I've only had one trial of Parnate and unfortunately it did not work for my atypical depression. Nardil works for me but really seems to cause a craving for sweet carbohydrates. I believe it also interfers with the feedback mechanism that tells your body when it is full. The only things that have controlled the Nardil weight gain for me are the complete elimination of carbohydrates, or exercising for 2+ hours per day.
Good Luck,
Jedi
Posted by gardenergirl on August 28, 2006, at 7:16:01
In reply to Re: MAOI's + Weight Gain » jealibeanz, posted by jedi on August 28, 2006, at 4:42:05
> ...
> > Well, anyway, my real question is, do MAOI-A's cause weight gain, while MAOI-B's do not? Are there any MAOI-B's available in the US, beside EMSAM at a lose dose?
> ...
> I believe it also interfers with the feedback mechanism that tells your body when it is full. The only things that have controlled the Nardil weight gain for me are the complete elimination of carbohydrates, or exercising for 2+ hours per day.That's exactly what it feels like. I remember noting when I was eating a great deal of carbs that it felt as if there was something "missing" in my brain. Something that used to kick in was not, and I "felt" the void.
Chromium picolinate (600 mcg) and Provigil seem to counter that a bit. I've lost 10 pounds from my peak weight, and I don't binge as much as I used to.
gg
Posted by silvercoin on August 28, 2006, at 7:58:49
In reply to Re: MAOI's + Weight Gain » jedi, posted by gardenergirl on August 28, 2006, at 7:16:01
> > ...
> > > Well, anyway, my real question is, do MAOI-A's cause weight gain, while MAOI-B's do not? Are there any MAOI-B's available in the US, beside EMSAM at a lose dose?
> > ...
> > I believe it also interfers with the feedback mechanism that tells your body when it is full. The only things that have controlled the Nardil weight gain for me are the complete elimination of carbohydrates, or exercising for 2+ hours per day.
>
> That's exactly what it feels like. I remember noting when I was eating a great deal of carbs that it felt as if there was something "missing" in my brain. Something that used to kick in was not, and I "felt" the void.
>
> Chromium picolinate (600 mcg) and Provigil seem to counter that a bit. I've lost 10 pounds from my peak weight, and I don't binge as much as I used to.
>
> gg
Nardil and Marplan are both hydrazine derivatives, and it has been known for close to 100 years that hydrazine derivatives can cause hypoglycemia (low blood sugar). One of the major symptoms is hunger. They can also interfere with glycogen metabolism, which can make it harder for the body to utilize energy.Todd
Posted by Another Phil on October 23, 2006, at 23:01:53
In reply to Re: MAOI's + Weight Gain, posted by silvercoin on August 28, 2006, at 7:58:49
For what it's worth, I'm one of the unlucky few who have gained weight while on Parnate. I've gained about 10 lbs that I can't seem to make a dent in. I eat sensibly and work out regularly, but I can't make any progress on the weight loss. I was only 150 lbs to begin with, so the extra 10 lbs gives me a noticeable little gut (at least when I look at myself in the mirror without a shirt on. It's quite unattractive.
Posted by elanor roosevelt on October 25, 2006, at 14:34:45
In reply to Re: MAOI's + Weight Gain, posted by silvercoin on August 28, 2006, at 7:58:49
on medicatins i went from 120 to 170 lbs in about 2 years
seems it started with the buspar, then some ad's that crashed me in the afternoon requiring ingestion of coffee and sugar to get through the workday, then the neurontin (might be mis-spelled should be banned) that just keep the pounds coming no matter what
i have been working out and buiding muscle. managed to get to 150 where i have been captive for 3 years -- i have struggle to stay at 150 bc over that the problems with my knees and feet start
the weight has caused many health issues for me
parnate has allowed me to lose weight at last
unfortunately i don't like the parnate
are you on other medications besides the parnate?
This is the end of the thread.
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