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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 17 of 17. This is the beginning of the thread.
Posted by Tom Twilight on July 28, 2006, at 15:24:30
Its interesting that high Glutimate levels are implicated in Anxiety and Depression.
Does anyone know if there are any Glutimate antagonists currently available?
Also are there any in development?
I suspect that my Glutimate levels are to high, is there anything that can be done about this?
Posted by Tom Twilight on July 28, 2006, at 15:28:40
In reply to Glutimate Antagonists, posted by Tom Twilight on July 28, 2006, at 15:24:30
a
Posted by Declan on July 28, 2006, at 15:36:01
In reply to Glutimate Antagonists, posted by Tom Twilight on July 28, 2006, at 15:24:30
This is the NMDA excitotoxicity thing?
Posted by JahL on July 28, 2006, at 16:15:59
In reply to Glutimate Antagonists, posted by Tom Twilight on July 28, 2006, at 15:24:30
> Does anyone know if there are any Glutimate antagonists currently available?
Hi Tom.
Riluzole, a antiglutamatergic approved for the treatment of ALS, is currently under investigation for its efficacy in mood disorders:
I tried it last year to no effect. Amazingly, I had it prescribed on The NHS.
Apparently Lamotrigene also has antiglutamatergic properties:
http://www.biopsychiatry.com/glutamate-mood.htm
Still heading for the States?
J.
Posted by silvercoin on July 28, 2006, at 16:22:55
In reply to Glutimate Antagonists, posted by Tom Twilight on July 28, 2006, at 15:24:30
> Its interesting that high Glutimate levels are implicated in Anxiety and Depression.
>
> Does anyone know if there are any Glutimate antagonists currently available?
>
> Also are there any in development?
>
> I suspect that my Glutimate levels are to high, is there anything that can be done about this?
Lamictal reduces glutamate transmission.Todd
Posted by Tom Twilight on July 28, 2006, at 16:42:35
In reply to Re: Glutimate Antagonists, posted by silvercoin on July 28, 2006, at 16:22:55
Hey all
Thanks for information about the Glutamate antagonists Jah
I am still keen to go to the states although I'm really not sure if I'll ever get it together enough to do so.
I've babblemailed you a couple of times about your experience with traveling to the US.
Don't like to do it to much though, I don't like to feel I'm stalking you!
Sorry Declan I'm not aware of NDMA Neurotoxicity theory.
I just know I feel anxious and that high Glutamate levels are linked to anxiety.
Posted by JahL on July 28, 2006, at 17:00:17
In reply to Re: Glutimate Antagonists, posted by Tom Twilight on July 28, 2006, at 16:42:35
> I am still keen to go to the states although I'm really not sure if I'll ever get it together enough to do so.Yeah, there's a lot of money and organisation involved. I suppose it depends on how big a difference it would make. It helped me a lot and there's a good chance I'll be returning since I no longer have a UK pdoc (f@*&%Łg NHS - they sent me to a tree-hugger).
> I've babblemailed you a couple of times about your experience with traveling to the US.
Sorry mate, my PC blew up (literally) recently and I'm borrowing a pal's laptop. I'm PC illiterate and can't access my main email a/c from this. I'll register my hotmail a/c with PB over the weekend.
> Don't like to do it to much though, I don't like to feel I'm stalking you!Hehe. I actually had a real-life stalker once. Pretty girl, but mad as anything.
Gimme a shout when it suits,
J.
Posted by blueberry on July 28, 2006, at 17:47:45
In reply to Glutimate Antagonists, posted by Tom Twilight on July 28, 2006, at 15:24:30
Hi Tom,
My doc said the only way to deal with excess glutamate is to drown it out with inhibitory neurotransmitters like serotonin and gaba. So ssri's and benzos partially work on anxiety through doing that. Antipsychotics also supposedly have some anti-glutamate functions. Lamictal supposedly reduces glutamate release.
On the natural side, taurine is a good glutamate neutralizer. Magnesium is too.
Posted by linkadge on July 28, 2006, at 20:59:22
In reply to Re: Glutimate Antagonists » Tom Twilight, posted by blueberry on July 28, 2006, at 17:47:45
Yeah, like blueberry said, magnesium, zinc too, vitamin c, theanine. Magnesium tends to be low in certain depression.
"My doc said the only way to deal with excess glutamate is to drown it out with inhibitory neurotransmitters like serotonin and gaba"
I don't know about the "only way".
Linakdge
Posted by Phillipa on July 29, 2006, at 12:29:35
In reply to Re: Glutimate Antagonists, posted by silvercoin on July 28, 2006, at 16:22:55
Todd is that good or bad? I'm not well versed in the chemical part of meds. Love Phillipa MDD and high very high anxiety.
Posted by Tom Twilight on July 29, 2006, at 15:31:33
In reply to Re: Glutimate Antagonists, posted by silvercoin on July 28, 2006, at 16:22:55
Hey Philipa
Glutamate antagonism should be good for anxiety in theory.
It depends where and when in the Brain of course!
Glutimate antagonists are in development for anxiety disorders, but its going to be a long time till we see them at this rate :(
Posted by SLS on July 29, 2006, at 19:13:37
In reply to Re: Glutimate Antagonists-Philipa, posted by Tom Twilight on July 29, 2006, at 15:31:33
Don't forget about memantine (Namenda). It is a non-competitive NMDA receptor antagonist. I tried it and experienced a brief improvement in depression. Riluzole didn't help at all. Magnesium supplements might help by providing a sufficient balance of antagonism at the NMDA receptor complex.
- Scott
Posted by linkadge on July 29, 2006, at 21:00:24
In reply to Re: Glutimate Antagonists-Philipa, posted by SLS on July 29, 2006, at 19:13:37
On theory is that all antidepressants essentially work by creating a regional dampening in glutamatergic function.
Linkadge
Posted by Sabre on July 30, 2006, at 2:58:30
In reply to Re: Glutimate Antagonists-Philipa, posted by SLS on July 29, 2006, at 19:13:37
How about Zinc, Glycine and D-Cycloserine?
They also inhibit NMDA receptors.Sabre
Posted by idolamine on July 30, 2006, at 21:33:40
In reply to Re: Glutimate Antagonists-Philipa, posted by SLS on July 29, 2006, at 19:13:37
Isn't Mg a cofactor for opening those NMDA channels? Or does it inhibit?
> Don't forget about memantine (Namenda). It is a non-competitive NMDA receptor antagonist. I tried it and experienced a brief improvement in depression. Riluzole didn't help at all. Magnesium supplements might help by providing a sufficient balance of antagonism at the NMDA receptor complex.
>
>
> - Scott
Posted by SLS on July 31, 2006, at 4:21:06
In reply to Re: Glutimate Antagonists-Philipa » SLS, posted by idolamine on July 30, 2006, at 21:33:40
Hi.
> Isn't Mg a cofactor for opening those NMDA channels? Or does it inhibit?
NMDA receptors are weird. At resting membrane potentials, magnesium acts to block the ion channel and prevents other ions from passing through into the neuron. As the neuronal membrane becomes depolararized by other types of glutamate receptors, the magnesium gets kicked off, allowing other ions such as calcium and sodium to enter, as long as the receptor remains stimulated by glutamate.
- Scott
Posted by SLS on July 31, 2006, at 6:48:16
In reply to Re: Glutimate Antagonists-Philipa, posted by SLS on July 31, 2006, at 4:21:06
Sorry for the verbose reply.
Mg inhibits.
> Hi.
>
> > Isn't Mg a cofactor for opening those NMDA channels? Or does it inhibit?
>
> NMDA receptors are weird. At resting membrane potentials, magnesium acts to block the ion channel and prevents other ions from passing through into the neuron. As the neuronal membrane becomes depolararized by other types of glutamate receptors, the magnesium gets kicked off, allowing other ions such as calcium and sodium to enter, as long as the receptor remains stimulated by glutamate.
>
>
>
> - Scott
This is the end of the thread.
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