Posted by SLS on July 31, 2006, at 4:21:06
In reply to Re: Glutimate Antagonists-Philipa » SLS, posted by idolamine on July 30, 2006, at 21:33:40
Hi.
> Isn't Mg a cofactor for opening those NMDA channels? Or does it inhibit?
NMDA receptors are weird. At resting membrane potentials, magnesium acts to block the ion channel and prevents other ions from passing through into the neuron. As the neuronal membrane becomes depolararized by other types of glutamate receptors, the magnesium gets kicked off, allowing other ions such as calcium and sodium to enter, as long as the receptor remains stimulated by glutamate.
- Scott
poster:SLS
thread:671467
URL: http://www.dr-bob.org/babble/20060724/msgs/672214.html