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Dr. Bob is Robert Hsiung, MD,
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Posted by linkadge on April 11, 2006, at 19:15:23
According to this page, mice lacking PKC epsilon are more sensitive to their own internal levels of GABA.
Note. Depakote decreases PKC alpha PKC epsilon.
http://www.modern-psychiatry.com/anxiety_disorders.htm
Linkadge
Posted by linkadge on April 11, 2006, at 19:18:43
In reply to PKC-epsiolon knockout mice more sensitive to GABA, posted by linkadge on April 11, 2006, at 19:15:23
I think that quercetin is also a PKC-e inhibitor.
Linkadge
Posted by Phillipa on April 11, 2006, at 22:55:57
In reply to Re: PKC-epsiolon knockout mice more sensitive to GABA, posted by linkadge on April 11, 2006, at 19:18:43
Link you lost me completely. Love Phillipa
Posted by linkadge on April 12, 2006, at 20:31:24
In reply to Re: PKC-epsiolon knockout mice more sensitive to GABA » linkadge, posted by Phillipa on April 11, 2006, at 22:55:57
It basically seems that mice who have less of an enzyme called PKC-epsilon are more sensitive to their bodies own calming gabaergic neurotransmitters like allopregnanalone.
This article was suggesting this as a possible way to treat anxiety disorders by using drugs that reduce PKC-e activity. Depakote appears to have this property (among others)
Linkadge
Posted by Caedmon on April 16, 2006, at 19:25:53
In reply to Re: PKC-epsiolon knockout mice more sensitive to GABA, posted by linkadge on April 12, 2006, at 20:31:24
Link what are your thoughts on using valproates to treat anxiety? It seems reasonable, except that most people won't tolerate the metabolic stuff. But it seems like if I were given a choice between Depakote and (say) Zyprexa for anxiety I'd go for the Depakote.
- C
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