Psycho-Babble Medication Thread 610181

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Reward Deficiency Syndrome, Motivation and ADD

Posted by psychopharmaddict on February 16, 2006, at 8:41:08

Im looking for some imput on anyone familiar with these closely related ailments. To keep it short, My symptoms before being diagnoses with ADD, but unsure if im 100 percent on having RDS, and or extreme Social Isolation,or Social Axiety to call it. But when I was Administered 30mg of adderal IR, 2-3x daily, It was like someone tapped into my brain and rewired it correctly.

Lack of motivation, just laying around watching tv, almost non existant love live from not going out at all, never going on my computer to research, and about 5 other important issues, but adderall had made me the exact opposite, Motivated, I could work 10 hrs, and then blab for one hour, and go online for another 4 hrs!.

Would anyone agree with my phylosiphy of possibly my ADD is deep limbic inactivity or too much activity and not enough being released into the prefrontal lobes. I never had a SPECT or PET scan, but I often wonder what was the problem , specifically, except for a doctor saying I have ADD and giving me adderall., at 30mg 3x daily , a pretty high dose.

I know its not serotonin releated, after trying 6 different serotonin/NE meds with little efficentcy, and Im not depressed. Again, my response to Amphetamines was phenominal, with a little bit of klonopin to take the edge off, but now i feel i need adderall for rest of my life, or until a new drug (NOT STRATTERRA) arises.

 

Re: Reward Deficiency Syndrome, Motivation and ADD

Posted by blueberry on February 16, 2006, at 17:09:46

In reply to Reward Deficiency Syndrome, Motivation and ADD, posted by psychopharmaddict on February 16, 2006, at 8:41:08

I agree with you that the sydromes of apathy and amotivation are in the ADD family. They aren't exactly the same, but very similar. I think the same circuitry is involved, primarily with dopamine and norepinephrine. Whether it has to do with actual neurotransmitter levels or whether it has to do with firing and release I think varies from person to person. And of course the different parts of the brain, like you said, are involved and make it more complicated.

Whatever though, it's nice to hear someone has found something that works fairly well without too many burdensome problems.

Stimulant and benzo? Wow, I wish I had your doc! Not too many would do that, though I honestly think it would save a whole lot of pain, suffering, and money if they did. After all, they are supposed to be improving the quality of our lives, right? Sounds like yours is doing that.

 

Re: Reward Deficiency Syndrome, Motivation and ADD

Posted by SLS on February 18, 2006, at 7:30:18

In reply to Reward Deficiency Syndrome, Motivation and ADD, posted by psychopharmaddict on February 16, 2006, at 8:41:08

Hi.

Reward deficiency and loss of motivation are two features of my illness too.

My condition looks very much like the deficit syndrome usually associated with the negative symptoms of schizophrenia. It seems to overlap with your description quite a bit. However, I have had brief responses to standard antidepressants as well as stimulants. My best response was to a combination of Parnate + desipramine. I would probably be on those same drugs today if the doctor hadn't discontinued them prematurely. I no longer respond to them.

http://www.biopsychiatry.com/anhedschiz.htm

The main features of my depression are anergia, psychomotor retardation, anhedonia, loss of interest and motivation, impaired cognition and concentration, reduced libido, hyperphagia, and hypersomnia. Because I have experienced several medication-induced manias, it is assumed that my condition is the result of a bipolar diathesis. When I do respond to something, the response lasts for a few days to a week at most. Some drugs have worked episodically for three weeks, but nothing compares to the smooth and consistent remission I achieved with the MAOI + TCA combination.


- Scott


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