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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 11 of 11. This is the beginning of the thread.
Posted by becksA on December 18, 2005, at 13:26:43
Is this possible? I've told my pdoc stories that have completely shocked him....really things that are not safe...examples:
Very high dose of Effexor for about 4 months, stopping cold turkey. Not one noticeable side effect.
12mg daily Xanax XR for about 6 months. Was able to completely stop that within about 7-10 days.
No SSRI's have ever done a single thing for me, good or bad, maybe because I just need a much higher dose than the norm?
Currently I'm with a new pdoc who I really like, we're using depakote and serax to attack social anxiety and mild mood swings. Anyway, about all that ridiculous med tolerance, is this common? I feel like a piece of my brain is missing, I hear all these horrible withdrawal stories none of which I have ever experienced.
thanks
Posted by jamestheyonger on December 18, 2005, at 13:31:20
In reply to born with super-high med tolerance?, posted by becksA on December 18, 2005, at 13:26:43
Some people are rapid metabolizers so they need higher doses to get the same effect that most people do at a lower dose.
Posted by becksA on December 18, 2005, at 14:23:55
In reply to Re: born with super-high med tolerance?, posted by jamestheyonger on December 18, 2005, at 13:31:20
That must be me I guess....and apparently it has to do with comedown, or my lack of withdrawals that I have experienced?
Interestingly enough I had previously thought my metabolism was so bad because I have to workout constantly and watch what I eat very carefully to maintain my physique.
Posted by inquisitive1 on December 18, 2005, at 14:29:51
In reply to Re: born with super-high med tolerance?, posted by becksA on December 18, 2005, at 14:23:55
I have to agree with James. Your doc may not have figured out your chemistry at this time. You also may find the following article useful:
Posted by becksA on December 18, 2005, at 14:33:32
In reply to Re: born with super-high med tolerance?, posted by inquisitive1 on December 18, 2005, at 14:29:51
thank you.
Posted by jamestheyonger on December 18, 2005, at 18:59:46
In reply to Re: born with super-high med tolerance?, posted by becksA on December 18, 2005, at 14:23:55
"Interestingly enough I had previously thought my metabolism was so bad because I have to workout constantly and watch what I eat very carefully to maintain my physique."
That is not the same thing as how fast you metabolize meds.
Posted by Phillipa on December 18, 2005, at 22:20:56
In reply to Re: born with super-high med tolerance?, posted by jamestheyonger on December 18, 2005, at 18:59:46
It's not? And can you go from a slow metabolizer to a fast metabolizer? Seems to be what's happened to me. Fondly, Phillipa
Posted by Sarah T. on December 18, 2005, at 22:56:29
In reply to born with super-high med tolerance?, posted by becksA on December 18, 2005, at 13:26:43
Hi BecksA,
I read your post with great interest -- and envy! I am at the other end of the spectrum. I can barely tolerate anything, especially drug combinations, and it seems to be getting worse. It just goes to show how different each one of us is as far as our reactions to medications. Psychobabblers seem to understand this, and some psychiatrists are finally beginning to learn this, too.
S.
Posted by bigcat on December 19, 2005, at 23:03:22
In reply to born with super-high med tolerance?, posted by becksA on December 18, 2005, at 13:26:43
> Is this possible? I've told my pdoc stories that have completely shocked him....really things that are not safe...examples:
>
> Very high dose of Effexor for about 4 months, stopping cold turkey. Not one noticeable side effect.
>
> 12mg daily Xanax XR for about 6 months. Was able to completely stop that within about 7-10 days.
>
> No SSRI's have ever done a single thing for me, good or bad, maybe because I just need a much higher dose than the norm?
>
> Currently I'm with a new pdoc who I really like, we're using depakote and serax to attack social anxiety and mild mood swings. Anyway, about all that ridiculous med tolerance, is this common? I feel like a piece of my brain is missing, I hear all these horrible withdrawal stories none of which I have ever experienced.
>
> thanksI'm in the exact same boat. I've taken mega-high doses of virtually every antidepressant, and they hardly touch me. Very mild side effects at doses 3x the recommended max. No withdrawal symptoms either, even when moving from a huge dose of one med straight to another, without tapering. While most meds have been failures, if a drug does something, I tend to respond virtually immediately with 100% remission, and then it fizzles out just as fast, and raising the dose does nothing to bring back the relief. I want to see an experienced psychopharamologist who would be willing to put me on VERY high doses. If that's really been my main problem this whole time, I'll shoot myself.
I simply can't relate with people who have to discontinue meds because of side effects. I've tried virtually every antidepressant at very high doses and have NEVER discontinued a med because of intolerable side effects. Besides being a fast metabolizer, I wonder if there are any ways to counter-act this (besides simply taking enormous doses). Well, I thought I was the only one...Any thought would be greatly appreciated.
Posted by Paulbwell on December 22, 2005, at 3:12:38
In reply to Re: born with super-high med tolerance? » becksA, posted by bigcat on December 19, 2005, at 23:03:22
> > Is this possible? I've told my pdoc stories that have completely shocked him....really things that are not safe...examples:
> >
> > Very high dose of Effexor for about 4 months, stopping cold turkey. Not one noticeable side effect.
> >
> > 12mg daily Xanax XR for about 6 months. Was able to completely stop that within about 7-10 days.
> >
> > No SSRI's have ever done a single thing for me, good or bad, maybe because I just need a much higher dose than the norm?
> >
> > Currently I'm with a new pdoc who I really like, we're using depakote and serax to attack social anxiety and mild mood swings. Anyway, about all that ridiculous med tolerance, is this common? I feel like a piece of my brain is missing, I hear all these horrible withdrawal stories none of which I have ever experienced.
> >
> > thanks
>
> I'm in the exact same boat. I've taken mega-high doses of virtually every antidepressant, and they hardly touch me. Very mild side effects at doses 3x the recommended max. No withdrawal symptoms either, even when moving from a huge dose of one med straight to another, without tapering. While most meds have been failures, if a drug does something, I tend to respond virtually immediately with 100% remission, and then it fizzles out just as fast, and raising the dose does nothing to bring back the relief. I want to see an experienced psychopharamologist who would be willing to put me on VERY high doses. If that's really been my main problem this whole time, I'll shoot myself.
>
> I simply can't relate with people who have to discontinue meds because of side effects. I've tried virtually every antidepressant at very high doses and have NEVER discontinued a med because of intolerable side effects. Besides being a fast metabolizer, I wonder if there are any ways to counter-act this (besides simply taking enormous doses). Well, I thought I was the only one...Any thought would be greatly appreciated.
There are ppl here who require 120mgs Dextroamphetamphetamine* to acheive relieve of their troiubles, from ADD/HD and higher doses of Adderall (LAmphetamine*Dextroamphetamine) for adaquate relieve of symptoms.Good luck
Posted by Sebastian on December 23, 2005, at 17:26:29
In reply to Re: born with super-high med tolerance? » becksA, posted by bigcat on December 19, 2005, at 23:03:22
I think you should try a different type of drug. Try zyprexa it is very strong at low doses. I am the same with antidepresants I take high doses and get not much relife.
This is the end of the thread.
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