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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 9 of 9. This is the beginning of the thread.
Posted by ace on January 7, 2004, at 18:52:57
Been on Ami for 5 weeks and 4 days...I upped it to 100mg for 4 days, but made anxiety worse. Rest of time its been at 50mg. Hasn;t really helped much, except tiny bit OCD and derealization.
Is my trial long enough?
I swithced to Zyprexa last night, but i could switch back to Ami...but no more than 2 day break or i have to start trial again...
Please help...
Ace.
Posted by SLS on January 7, 2004, at 19:19:30
In reply to Amisulpride- 5 and a half weeks...need advice now!, posted by ace on January 7, 2004, at 18:52:57
> Been on Ami for 5 weeks and 4 days...I upped it to 100mg for 4 days, but made anxiety worse. Rest of time its been at 50mg. Hasn;t really helped much, except tiny bit OCD and derealization.
>
> Is my trial long enough?
>
> I swithced to Zyprexa last night, but i could switch back to Ami...but no more than 2 day break or i have to start trial again...
>
> Please help...
>
> Ace.
Generally speaking, I think if amisulpride is going to work against depression, it will produce some improvement by the end of week two. 50mg seems to be the ideal dosage.Wait for others to chime in. I think I read a post recently describing a 6 or more week wait for amisulpride to kick in. However, it seems to me that 5 weeks is an adequate trial.
Dear Ace, what are you looking for?
- Scott
Posted by ace on January 7, 2004, at 19:33:35
In reply to Re: Amisulpride- 5 and a half weeks...need advice now!, posted by SLS on January 7, 2004, at 19:19:30
Scotty, can you Locate that post where it took 6 weeks to have effect??
Cheers mate,
Andrew.>
> Generally speaking, I think if amisulpride is going to work against depression, it will produce some improvement by the end of week two. 50mg seems to be the ideal dosage.
>
> Wait for others to chime in. I think I read a post recently describing a 6 or more week wait for amisulpride to kick in. However, it seems to me that 5 weeks is an adequate trial.
>
> Dear Ace, what are you looking for?
>
>
> - Scott
>
>
>
>
Posted by scott-d-o on January 7, 2004, at 22:54:21
In reply to Amisulpride- 5 and a half weeks...need advice now!, posted by ace on January 7, 2004, at 18:52:57
> Been on Ami for 5 weeks and 4 days...I upped it to 100mg for 4 days, but made anxiety worse. Rest of time its been at 50mg. Hasn;t really helped much, except tiny bit OCD and derealization.
>
> Is my trial long enough?
>
> I swithced to Zyprexa last night, but i could switch back to Ami...but no more than 2 day break or i have to start trial again...
>
> Please help...
>
> Ace.I think I replied to your post at two weeks and said I thought even that was an adequate trial. I think it's clear at this point that this medication is not going to work for you. What exactly are you trying to treat anyhow? Perhaps I can recommend an alternative.
scott
Posted by rod on January 8, 2004, at 5:28:43
In reply to Amisulpride- 5 and a half weeks...need advice now!, posted by ace on January 7, 2004, at 18:52:57
This might hurt, but I have to tell you what comes into my mind ;)
I agree with scott-d-o. I dont think it works for you. Did you change the dosage of Nardil? The last information I could remember was 105mg. Right? Did you increase it since you started Amisulpride? Didnt you take it at a lower dose, before you started Amisulpride? Ok, I admit I am too lazy to look it up ;)
In general, I doubt a dopaminergic agent works for OCD. Arent they contraindicated for OCD in general? But you said you have a somewhat atypical OCD, whatever this means. BTW could you describe your OCD a little better? Any rituals?
If you look at pubmed, many abstracts state ocd and ad(h)d are inverse neurochemic situations. Amisulpride activates for example the forebrain (it increases attention and concentration for me), while in calssic OCD it is already overstimlated (hyerglutamiergic state of the forebrain in OCD). And most serotonergic agents seem to correct this state of overactivity. BTW, did you try any other SSRI besides Zoloft (Sertraline)?? Didnt you take this one? My personal opinion about Sertraline is that is not the best drug to treat OCD. What about Luvox, Celexa, Lexapro? I know, you once tried Anafranil which resulted in what you described as serotonin synndrome. Too short period between switching nardil and anafranil? I dont know. I dont want to influence you since you seem to do great with Nardil. Im just curiousRoland
Posted by rod on January 8, 2004, at 6:09:55
In reply to Amisulpride- 5 and a half weeks...need advice now!, posted by ace on January 7, 2004, at 18:52:57
...OCD and ADHD/DAMP are common neuropsychiatric conditions which in many regards appear to be each other's antipodes with respect to clinical manifestations, associated personality traits and brain biochemistry, notably prefrontal cortical glutamate activity...
"On the role of prefrontal cortex glutamate for the antithetical phenomenology of obsessive compulsive disorder and attention deficit hyperactivity disorder."
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11263758&dopt=Abstract
BTW, hows the weather in Australia? In my place its freezing cold and snowing.
You arent this crazy australion guy on TV who catches snakes and crocodiles with his own hands? Thats how I imagine a crazy nardil hypomaniac LOL. just joking ;)
Posted by ace on January 8, 2004, at 18:52:25
In reply to Re: Amisulpride- 5 and a half weeks...need advice now! ? ace, posted by rod on January 8, 2004, at 5:28:43
> This might hurt, but I have to tell you what comes into my mind ;)
> I agree with scott-d-o. I dont think it works for you.I agree too.
Did you change the dosage of Nardil? The last information I could remember was 105mg. Right? Did you increase it since you started Amisulpride? Didnt you take it at a lower dose, before you started Amisulpride? Ok, I admit I am too lazy to look it up ;)
I increase it from 90mg to 105mg about 4 days ago.
> In general, I doubt a dopaminergic agent works for OCD. Arent they contraindicated for OCD in general?
Not that I know off- I mean OCD per se, does not exist IMO, that is, I believe it doesn't have the same underriding aetiology in all people. For some dopaminergic agents could work...
But you said you have a somewhat atypical OCD, whatever this means. BTW could you describe your OCD a little better? Any rituals?I have this thought that something is going to destroy my happiness...then this other thought in my head tries to come in and say "yes" to the thought...sort of like tries to override what i truly want...the ritual is where i say "no" over the "yes"...I also have a fixation on infinity which is painful...it is clear OCD, however- it in the family relatives too!
> If you look at pubmed, many abstracts state ocd and ad(h)d are inverse neurochemic situations. Amisulpride activates for example the forebrain (it increases attention and concentration for me), while in calssic OCD it is already overstimlated (hyerglutamiergic state of the forebrain in OCD). And most serotonergic agents seem to correct this state of overactivity. BTW, did you try any other SSRI besides Zoloft (Sertraline)??Luvox- but only 2 days.
Didnt you take this one?
Zoloft was of little benifit for me after 2 wasted years on 200mg...didn't help depression much, if at all.
My personal opinion about Sertraline is that is not the best drug to treat OCD. What about Luvox, Celexa, Lexapro? I know, you once tried Anafranil which resulted in what you described as serotonin synndrome. Too short period between switching nardil and anafranil?
Correct.
I dont know. I dont want to influence you since you seem to do great with Nardil. Im just curious
Nardil is a lifesaver in so many ways. I can't drop it. Ive added 2.5mg Zyprexa which almost abolishes the infinity fixation. And that was only after 3 weeks, so 8 weeks of Zyprexa will probably do soo much.
Any other ideas? how about Neurontin? Thanks so much dude,
Ace.
Nardil 105mg
Zyprexa 2.5mg.
> Roland
Posted by rod on January 8, 2004, at 19:57:31
In reply to Re: Amisulpride- 5 and a half weeks...need advice now! » rod, posted by ace on January 8, 2004, at 18:52:25
> Any other ideas? how about Neurontin?
Go and find out. If your doctor is able and willing to prescribe it, I would try it.
For me, Neurontin does a great job so far. It reduces anxiety (especially social anx.), improves memory and concetration for me. Its like Neurontin clears up my mind. My thoughts are a lot more organised. I can focus a lot better on an idea. But its still not enough.
Futhermore, Neurontin is not just an GABA-agonist which directly binds to the GABA receptors. It also reduces noradrenergic activity (I do bad on noradrenergics) and also indirectly reduces glutamergic activity and blocks some special calcium channel types (L-Type as far as I remember. But I dont know what the calcium channel blockade it good for, but I guess it results in neuroprotection, since memantine blocks the nmda receptor, which acts as a calcium pump, when activated by glutamate. And too Much calcium in the cell is believed to result in neuronal death). Also the reduced glutamate results in neuroprotection. Thats anohter point why I take it besides I may have some kind of subsyndromal epilepsy, but this never got clearly diagnosed. Maybe the good effects are only due decreased anxiety. Whatever, as long as I benefit from it, I will take it. I love it!I wish you luck in "convincing" your doc to prescribe it ;)
Roland
Posted by ace on January 9, 2004, at 16:59:38
In reply to Re: Amisulpride- 5 and a half weeks...need advice now! » ace, posted by rod on January 8, 2004, at 6:09:55
> BTW, hows the weather in Australia?Hot!
In my place its freezing cold and snowing.
> You arent this crazy australion guy on TV who catches snakes and crocodiles with his own hands? Thats how I imagine a crazy nardil hypomaniac LOL. just joking ;)
>Hey no one was supposed to know that!!!! It's the Nardil that gives me the strength bro!!! Nardil can kill a crocidile!!!!
Best to you bro,
Ace.
This is the end of the thread.
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