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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 10 of 10. This is the beginning of the thread.
Posted by MamaB on October 27, 2003, at 18:13:01
Hi,
I posted a while back that the first time I tried Strattera for my ADD I wound up having a "mimi-menopause" I went through menopause over 10 years ago. (hot flushes, anxiety ,grumpy etc) I then had some vaginal bleeding. Someone posted that they had had bleeding between periods and sore breasts.
I have been doing some research on the relationship between Estrogens and norepinephrin,
and have come across a few interesting facts. If anyone else out there who is on Strattera has had similar symptoms, could you please post? I see my psychiatrist next week and would like to let him know my findings, and that I am not the only one who has experienced "hormonal difficulties" (for lack of a better term) while on Strattera.
Thanks, MamaB
Posted by Zenclearer on October 27, 2003, at 18:37:34
In reply to Attention Female Strattera users, posted by MamaB on October 27, 2003, at 18:13:01
Many women complain of really BAD PMS on Wellbutrin, another norep-inhibitor. I think it's quite likely Straterra might cause the problems you report, although I don't have any facts on hand.
Posted by MamaB on October 27, 2003, at 19:18:07
In reply to Re: Attention Female Strattera users » MamaB, posted by Zenclearer on October 27, 2003, at 18:37:34
> Many women complain of really BAD PMS on Wellbutrin, another norep-inhibitor. I think it's quite likely Straterra might cause the problems you report, although I don't have any facts on hand.
I guess I really lucked out -- I didnt start on Wellbutrin until I was post menopause! I wonder if the combo did the dirty deed? I have always looked at Wellbutrin as more on the Dopamine-reup inhibitor although I know it effects both.
Posted by loolot on October 27, 2003, at 20:39:44
In reply to Attention Female Strattera users, posted by MamaB on October 27, 2003, at 18:13:01
Hi MamaB
Im still on my strattera, but I dont know if Ill stay on it. I did have spotting the one time I mentioned to you, and I my period is still a week or so away.
My breasts are like twice as large now and very tender, too, so I definitely think there is some kind of hormone connection with the strattera.
The strange thing is that I took provigil and I didnt get any such reactions, and provigil is supposed to work purely on noradrenaline, too. Complicated.
I have noticed night sweats, but I attribute that to the fact that I take my dose around dinner time, so by the middle of the night I am sweating it out, unfortunately I wake up with a sore throat, exhausted the next day. In fact at this point I think I am actually getting sick because of lowered immune function or dehydration from strattera. I dont know.
What is the hormone connection?
Posted by loolot on October 27, 2003, at 20:41:46
In reply to Re: Attention Female Strattera users, posted by MamaB on October 27, 2003, at 19:18:07
I didnt have those problems on Wellbutrin. No hormone type problems that I noticed
Posted by sadmom on October 28, 2003, at 9:42:50
In reply to Re: Attention Female Strattera users » MamaB, posted by loolot on October 27, 2003, at 20:41:46
I had morning sweating when I take Strattera. But it went away, when I started 30 mg Remeron last week. Now I'm having a problem with Remeron making my body too cold at night.
Posted by MamaB on October 29, 2003, at 6:30:11
In reply to Re: Attention Female Strattera users » MamaB, posted by loolot on October 27, 2003, at 20:39:44
Loolot,
Sorry it has taken me a while to get back to you. here is the crux of what I have found:1.Estrogen has some effect on the Tyrosine Hydroxolase which is the "rate controlling mechanism" (enzyme) produced in the hypothalamus that limits the production of norepinephrine.
2.Estrogen is reported to inhibit extra-neuronal uptake of norepinephrine, thus increasing norepinephrine concentrations.
3.Some very early studies (Sawyer et al. 1949-1950) with rabbits indicated that administration of drugs that block norepinephrine/epinephrine when administered at the highest point of production of the estrogens, prevents/inhibits further release of LH (lutenizing hormone) precursor to FSH and therefore to estrogen.
About the only conclusion I have drawn here is that there is a correlation of some sort. I plan to show all of this to my psychiatrist and see what he thinks.
Sorry it is not more conclusive, I will keep reading. MB
Posted by MamaB on October 29, 2003, at 9:27:03
In reply to Re: Attention Female Strattera users, posted by MamaB on October 29, 2003, at 6:30:11
> Loolot,
> Sorry it has taken me a while to get back to you. here is the crux of what I have found:
>
> 1.Estrogen has some effect on the Tyrosine Hydroxolase which is the "rate controlling mechanism" (enzyme) produced in the hypothalamus that limits the production of norepinephrine.
>
> 2.Estrogen is reported to inhibit extra-neuronal uptake of norepinephrine, thus increasing norepinephrine concentrations.
>
> 3.Some very early studies (Sawyer et al. 1949-1950) with rabbits indicated that administration of drugs that block norepinephrine/epinephrine when administered at the highest point of production of the estrogens, prevents/inhibits further release of LH (lutenizing hormone) precursor to FSH and therefore to estrogen.
>
> About the only conclusion I have drawn here is that there is a correlation of some sort. I plan to show all of this to my psychiatrist and see what he thinks.
> Sorry it is not more conclusive, I will keep reading. MBIf you are interested in reading about the relationship of Estrogen and its effect on neurotransmitters in the brain, I recommend this site (its a pretty easy read.)
http://www.macalester.edu/~psych/whathap/UBNRP/Estrogen/ERTmood.html
Posted by loolot on October 29, 2003, at 10:43:16
In reply to Re: Attention Female Strattera users, posted by MamaB on October 29, 2003, at 6:30:11
Hi MamaB!
Thanks for this research! Interesting
>
> 3.Some very early studies (Sawyer et al. 1949-1950) with rabbits indicated that administration of drugs that block norepinephrine/epinephrine when administered at the highest point of production of the estrogens, prevents/inhibits further release of LH (lutenizing hormone) precursor to FSH and therefore to estrogen.>>So if drugs that block norep. inhibit the precursor of estrogen, then does this mean that norepinephrine in excess would lead to excess estrogen? I wonder if it leads to other hormones inexcess too, like testosterone (another steroid, aside from estrogen) and progesterone?
Posted by MamaB on October 29, 2003, at 13:41:02
In reply to Re: Attention Female Strattera users » MamaB, posted by loolot on October 29, 2003, at 10:43:16
Loolot, I will check for an answer to your question as soon as I can. Also did not give citations for the above info. If you want me to I will post them. MamaB
This is the end of the thread.
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