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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 10 of 10. This is the beginning of the thread.
Posted by freedom2001 on April 29, 2003, at 0:24:18
A transgenic model of comorbid Tourette's syndrome and obsessive-compulsive disorder circuitry
EJ Nordstrom, FH Burton
Mice were genetically engineered to mimic the heightened regional brain activity thought to be associated with Comorbid Tourette's Syndrome and Obsessive-Compulsive Disorder (TS+OCD). These mice exhibit not only OCD-like behaviors but TS-like ticcing, including increased tic number, complexity and flurries, more severe tic flurries in males, juvenile onset of ticcing, ability to temporarily suppress ticcing, and tic responsiveness to a therapeutic TS+OCD drug, clonidine.
"This supports a cortical-limbic glutamatergic neuron (CGN) 'hyperactivity' model of TS+OCD, which may lead to new anti-glutamatergic drug treatments for this human disorder."
Posted by ace on April 29, 2003, at 2:12:01
In reply to NEW DISCOVERY ON OCD, posted by freedom2001 on April 29, 2003, at 0:24:18
Posted by McPac on April 29, 2003, at 19:22:09
In reply to NEW DISCOVERY ON OCD, posted by freedom2001 on April 29, 2003, at 0:24:18
Great find freedom!!!
Posted by McPac on April 29, 2003, at 19:23:16
In reply to NEW DISCOVERY ON OCD, posted by freedom2001 on April 29, 2003, at 0:24:18
freedom, do you have the whole post (incl. date)?
Posted by freedom2001 on April 29, 2003, at 22:20:35
In reply to Did you get my email? I sent it few days ago. (nm) » freedom2001, posted by ace on April 29, 2003, at 2:12:01
No I did not Ace.
The yahoo email you gave me, I sent to it and got a bounced back error reply.
my e-mail is alphalht@singnet.com.sg
a - america
l - london
p - pirates
h - hong kong
a - america
l - london
h - hong kong
t - thailandpls try again OR give me a new Email account that I can send to.
Regards,
freedom.
Posted by freedom2001 on April 29, 2003, at 22:40:19
In reply to Re: NEW DISCOVERY ON OCD, posted by McPac on April 29, 2003, at 19:22:09
> Great find freedom!!!
Thanks.
It's my duty to share all important information with OCD sufferers.
So glutamatergic system is probably involved in OCD as well. All the more to avoid glutamate things! I hope an anti-glutamate drug will come out and add to the arsenal of anti-OCD drugs!
Is there any ANTI-GLUTAMATERGIC DRUG CURRENTLY ON THE MARKET OR IN DEVELOPMENT?
Posted by freedom2001 on April 29, 2003, at 22:42:03
In reply to Re: NEW DISCOVERY ON OCD, posted by McPac on April 29, 2003, at 19:23:16
> freedom, do you have the whole post (incl. date)?
Can't remember.
maybe I used the key words
"Search of OCD gene" in googleor maybe I use "molecular psychiatry" in google.
Can't confirm.
Posted by ace on April 29, 2003, at 23:46:43
In reply to Re: Did you get my email? I sent it few days ago. ?ace, posted by freedom2001 on April 29, 2003, at 22:20:35
[xxx]
This better work!
Ace.
Posted by Questionmark on April 30, 2003, at 22:04:19
In reply to Re: NEW DISCOVERY ON OCD » McPac, posted by freedom2001 on April 29, 2003, at 22:40:19
> Is there any ANTI-GLUTAMATERGIC DRUG CURRENTLY ON THE MARKET OR IN DEVELOPMENT?
Benzodiazapines, i believe, are at least in some areas of the brain, indirectly anti-glutamatergic.
Posted by MattD on May 3, 2003, at 18:26:23
In reply to NEW DISCOVERY ON OCD, posted by freedom2001 on April 29, 2003, at 0:24:18
Tourette's has been thought of alongside OCD for years, basically because there is some compulsion and anxiety associated with the tics. Stuttering also shares common features with both--it responds well to D2 antogonists (as does T) and it involves a signficant obsessive "scanning" component.
I have a friend with Tourette's who has responded well to an SSRI.
Best,
Matt
> A transgenic model of comorbid Tourette's syndrome and obsessive-compulsive disorder circuitry
>
> EJ Nordstrom, FH Burton
>
> Mice were genetically engineered to mimic the heightened regional brain activity thought to be associated with Comorbid Tourette's Syndrome and Obsessive-Compulsive Disorder (TS+OCD). These mice exhibit not only OCD-like behaviors but TS-like ticcing, including increased tic number, complexity and flurries, more severe tic flurries in males, juvenile onset of ticcing, ability to temporarily suppress ticcing, and tic responsiveness to a therapeutic TS+OCD drug, clonidine.
>
> "This supports a cortical-limbic glutamatergic neuron (CGN) 'hyperactivity' model of TS+OCD, which may lead to new anti-glutamatergic drug treatments for this human disorder."
>
>
This is the end of the thread.
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