Posted by MattD on May 3, 2003, at 18:26:23
In reply to NEW DISCOVERY ON OCD, posted by freedom2001 on April 29, 2003, at 0:24:18
Tourette's has been thought of alongside OCD for years, basically because there is some compulsion and anxiety associated with the tics. Stuttering also shares common features with both--it responds well to D2 antogonists (as does T) and it involves a signficant obsessive "scanning" component.
I have a friend with Tourette's who has responded well to an SSRI.
Best,
Matt
> A transgenic model of comorbid Tourette's syndrome and obsessive-compulsive disorder circuitry
>
> EJ Nordstrom, FH Burton
>
> Mice were genetically engineered to mimic the heightened regional brain activity thought to be associated with Comorbid Tourette's Syndrome and Obsessive-Compulsive Disorder (TS+OCD). These mice exhibit not only OCD-like behaviors but TS-like ticcing, including increased tic number, complexity and flurries, more severe tic flurries in males, juvenile onset of ticcing, ability to temporarily suppress ticcing, and tic responsiveness to a therapeutic TS+OCD drug, clonidine.
>
> "This supports a cortical-limbic glutamatergic neuron (CGN) 'hyperactivity' model of TS+OCD, which may lead to new anti-glutamatergic drug treatments for this human disorder."
>
>
poster:MattD
thread:223065
URL: http://www.dr-bob.org/babble/20030429/msgs/224113.html