Psycho-Babble Medication Thread 89412

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Re: Klonopin -the drug of kings » IsoM

Posted by manowar on January 17, 2002, at 20:01:39

In reply to Re: Klonopin -the drug of kings » manowar, posted by IsoM on January 17, 2002, at 16:57:36

Hello again,
I take 200 mg of Provigil along with 150 mg of Wellbutrin in the morning. Then I take 150 mg of Wellbutrin in the afternoon.

> I wonered about using adrafinil & taking a benzo occasionally. So there's no problem with a trank in the evening affecting the Provigil the next day?
>
> Adrafinil does a good enough job for me for calmness & helps with sleep too, but there's times I'd like to use a trank (like dentist visits) & wondered.
>
> Very glad to hear that your cocktail's working so well for you. Do you take Provigil just in the morning then? And how much? Thanks, Tim!
>
> > Hello fellow Klono-pin heads!:)))
> >
> > I've been using the drug for years, and it has ALWAYS worked for me to calm me down at night and go to sleep. The smoothest sleeping agent I've ever had!
> >
> > Now, I take my entire daily dose (1.5 mg) at one time in the evening, which may have something to do with it.
> >
> > The fact is, taking the nightly dose is perfect for me and my cyclothymia. I sleep wonderfully at night and feel well rested in the morning. I take my Provigil and Wellbutrin in the morning and I feel stimulated but calm at the same time (there is a God in heaven!). When the effects of the Klonipin start to wear off is around 4-8 in the evening. Since I just take it as a mood stabilizer anyway, it’s not a big deal for me, and ITS ALMOST TIME FOR THE NEXT DOSE!
> > --Whoever invented Klonipin should win the Nobel Prize or something!
> >
> > Sincerely,
> >
> > Tim

 

Re: Klonopin -the drug of kings » manowar

Posted by Rick on January 18, 2002, at 2:12:45

In reply to Klonopin -the drug of kings, posted by manowar on January 17, 2002, at 16:08:35

My Klon-opinion is similar to yours. It's great, not just for my social phobia, but for sleep too.

In fact, I take it all (1.0 mg) in the morning with my Provigil (usually a low-ish 100 mg), yet the Klonopin still helps me sleep like a baby at night. That said, while I've never -- and don't intend to -- take Provigil by itself, I think Provigil may have a mild crashing effect as bedtime approaches that actually facilitates sleep. BTW, even though Provigil keeps me wide awake during the day, I have no problem taking a daytime nap when I want to. That kind of "user-control" is one of the things I love about Provigil, or more precisely about a Provigil/Klonopin combo.

P.S. When I take Klonopin at night, I sleep fine but actually feel somewhat *less* refreshed in the morning. So I guess our Klon-opinions aren't *completely* in synch.

Rick


> Hello fellow Klono-pin heads!:)))
>
> I've been using the drug for years, and it has ALWAYS worked for me to calm me down at night and go to sleep. The smoothest sleeping agent I've ever had!
>
> Now, I take my entire daily dose (1.5 mg) at one time in the evening, which may have something to do with it.
>
> The fact is, taking the nightly dose is perfect for me and my cyclothymia. I sleep wonderfully at night and feel well rested in the morning. I take my Provigil and Wellbutrin in the morning and I feel stimulated but calm at the same time (there is a God in heaven!). When the effects of the Klonipin start to wear off is around 4-8 in the evening. Since I just take it as a mood stabilizer anyway, it’s not a big deal for me, and ITS ALMOST TIME FOR THE NEXT DOSE!
> --Whoever invented Klonipin should win the Nobel Prize or something!
>
> Sincerely,
>
> Tim

 

Re: Klonopin -the drug of kings » manowar

Posted by Simcha on January 18, 2002, at 8:24:52

In reply to Klonopin -the drug of kings, posted by manowar on January 17, 2002, at 16:08:35

Heh Heh,

I am a fellow Klono-pin head! Ima druggie. Heeza druggie. Wouldn't 'ya like to be a druggie too? Be a druggie take the Klonopin!

LOL

Actually, I cannot imagine abusing this drug. It does not offer a high. There just is not any abuse value in it as far as I can see.

I've been on it for a little over a week. I take 1mg at night to stop grinding my teeth and the restless legs made worse by the SSRI I take in the morning, Celexa. I take my Wellbutrin in two doses, am and afternoon. It's just a splendid combo for now.

On this combo I actually feel like I'm balanced and I can feel my feelings without having them rule my life. I do not plunge into the depths of depression. I do not get anxiety attacks that cause me to seek out dozens of sexual partners per day. I'm actually doing well. Ten years of therapy and six years of 12-step alone did not do this.

All praise to the people who have discovered this chemical assistance!


> Hello fellow Klono-pin heads!:)))
>
> I've been using the drug for years, and it has ALWAYS worked for me to calm me down at night and go to sleep. The smoothest sleeping agent I've ever had!
>
> Now, I take my entire daily dose (1.5 mg) at one time in the evening, which may have something to do with it.
>
> The fact is, taking the nightly dose is perfect for me and my cyclothymia. I sleep wonderfully at night and feel well rested in the morning. I take my Provigil and Wellbutrin in the morning and I feel stimulated but calm at the same time (there is a God in heaven!). When the effects of the Klonipin start to wear off is around 4-8 in the evening. Since I just take it as a mood stabilizer anyway, it’s not a big deal for me, and ITS ALMOST TIME FOR THE NEXT DOSE!
> --Whoever invented Klonipin should win the Nobel Prize or something!
>
> Sincerely,
>
> Tim

 

Re: Klonopin -the drug of kings AAAAMEN!!! (nm)

Posted by kid47 on January 18, 2002, at 11:04:10

In reply to Klonopin -the drug of kings, posted by manowar on January 17, 2002, at 16:08:35

 

Re: Klonopin -the drug of kings » manowar

Posted by mr.scott on January 18, 2002, at 12:40:43

In reply to Klonopin -the drug of kings, posted by manowar on January 17, 2002, at 16:08:35

Tim,

You speak the truth about Klonopin. I almost got stuck taking Depa-crap (Depakote), but Klonopin handles things well enough without all associated problems.

Three cheers for clonazepam!

Scott

 

Klonipin- low abuse potential? I think so...

Posted by manowar on January 18, 2002, at 16:04:04

In reply to Klonopin -the drug of kings, posted by manowar on January 17, 2002, at 16:08:35

Hi again,
Simcha makes a very important point about Klonipin: It has a very LOW abuse potential. Xanax, and Diazepam work well for me too, but they cause euphoria. Now most people would think that euphoria is a good thing, and it is. The only problem is, it can very easily cause a psychological dependence the size of the state of Utah!

As a matter of fact, I've had doctors and others tell me before that Xanax is the most addicting drug there is. I happen to disagree with that assumption. The most addicting agent in the world is the drug that gives a user the greatest amount of euphoria. Therefore, because everyone is different, the most addictive drug in the world is the drug that's the most addictive drug for you--get it. But I think you could narrow the VERY addicting agents to:
Nicotine (Women seem to have a harder time than men with this one-generally)
Heroin
Crack cocaine
Methamphetamine
Xanax or Diazepam (I can't spell the trade name)

Anyone care to add to this list?

BTW: I'm very intrigued about the other less known benzos that have even a longer half-life than Klonipin. Could they even be more effective? Anyone ever used such benzos?

Thanks,

Tim

 

Klonopin is great, but how do you get off it?

Posted by AnneL on January 18, 2002, at 23:58:22

In reply to Klonipin- low abuse potential? I think so..., posted by manowar on January 18, 2002, at 16:04:04

I have been on Klonopin 1 mg. at bedtime for almost one year now, first as an anti-anxiety agent to get me through the start-up of Effexor and then as a sleep agent. I find it extremely sedating which is great for sleep.

But, I haven't heard anyone talk about how it feels to miss a dose. I have not taken it on 2 or 3 ocassions when I have indulged in 3 or more alcoholic beverages, the last time being New Year's Eve. By 4AM, I was in the midst of a severe Klonopin withdrawal. I really feel for those who are addicted to drugs like heroin, etc.
The only thing that took away the body twitching, extreme anxiety, etc., was a dose of Klonopin at 4:30 AM. It was a living hell for 30 minutes and I dread the day when I taper off of this drug. Any comments?

 

Tapering Klonopin/Other Benzos

Posted by Mr. Scott on January 19, 2002, at 1:21:25

In reply to Klonipin- low abuse potential? I think so..., posted by manowar on January 18, 2002, at 16:04:04

I may sound arrogant here, but it is only because I KNOW what I am talking about. Having suffered from anxiety for years I have used most of the benzos and discovered some great ways to come off of them.

In terms of efficacy for Anxiety, no drug is better than Xanax. Because not only does it kick anxiety's ass, but it doesn't mess up your head quite as much as Klonopin (attention span and memory problems). Of course it is a bitch to come off of and I did develop tolerance to the anti-anxiety effects after a couple years (poop-out). I find Ativan and Klonopin to be the worst in terms of memory problems, but also highly effective for agitation, anxiety, AD induced problems, or other states involving overarousal. Also the anti-anxiety effect of Klonopin never pooped out on me..Go figure.

One of my favorite benzodiazepines is Tranxene (chlorazepate). You feel ZERO euphoria and it has the longest half-life of any benzo marketed in the US with the exception of Dalmane.

Also, Neurologists have found that tolerance to the anti-convulsant effect of Tranxene does not develop.

This brings me to tapering klonopin. Jump over to tranxene and simply drop the dose comfortably every two weeks. You won't notice much of anything until the last taper. At that point use 200mg of Neurontin PRN if needed at all for a week or two. Just be patient and determined because as your anxiety slowly returns, you will convince yourself to go back on the drug (psychological dependence indeed).

Tranxene seems to me to be more anticholinergic than Klonopin, but ironically causes hardly any cognitive problems. It is best suited for withdrawal and generalized anxiety and tension rather than mania.

Thats my two cents

Scott

 

Re: Klonopin is great, but how do you get off it? » AnneL

Posted by Rick on January 19, 2002, at 3:36:36

In reply to Klonopin is great, but how do you get off it?, posted by AnneL on January 18, 2002, at 23:58:22

I guess everyone's different. I also take 1 mg, but all in the a.m. I've been taking it for two and a half years, starting at 3 mg, and have found I need less over time. One day a few months ago I went on an overnight trip and managed to leave my Klonopin back home (not smart). I ended up going about 42 hours between doses. The only result was a moderate rebound of my social anxiety during the latter part of that period.

Based the incident you related, my suggestion would be that, as long as you're on Klonopin, you should deny yourself the special-occasion booze. Or take just a very small amount of Klonopin on those nights, e.g. 1/4 mg, which should be safe even if it's potentiated by a factor of four. Then take more the next morning or afternoon if you feel any withdrawal symptoms.

Other things to consider: See if you can get by on less (but with S-L-O-W taper). If your insomnia stems from anxiety, then Klonopin doesn't need to be sedating to help you get to sleep and stay asleep. It just needs to keep anxiety in check. Even though I take it all in the a.m., and don't find it sedating unless I take more than usual, it still relieves the insomnia I used to have.

Rick

> I have been on Klonopin 1 mg. at bedtime for almost one year now, first as an anti-anxiety agent to get me through the start-up of Effexor and then as a sleep agent. I find it extremely sedating which is great for sleep.
>
> But, I haven't heard anyone talk about how it feels to miss a dose. I have not taken it on 2 or 3 ocassions when I have indulged in 3 or more alcoholic beverages, the last time being New Year's Eve. By 4AM, I was in the midst of a severe Klonopin withdrawal. I really feel for those who are addicted to drugs like heroin, etc.
> The only thing that took away the body twitching, extreme anxiety, etc., was a dose of Klonopin at 4:30 AM. It was a living hell for 30 minutes and I dread the day when I taper off of this drug. Any comments?

 

Re: Klonipin- low abuse potential? I think so... » manowar

Posted by Rick on January 19, 2002, at 3:46:14

In reply to Klonipin- low abuse potential? I think so..., posted by manowar on January 18, 2002, at 16:04:04

But I think you could narrow the VERY addicting agents to:
> Nicotine (Women seem to have a harder time than men with this one-generally)
> Heroin
> Crack cocaine
> Methamphetamine
> Xanax or Diazepam (I can't spell the trade name)
>
> Anyone care to add to this list?

Chocolate
Potato Chips ("Crisps" for British P-B-ers)
>
> BTW: I'm very intrigued about the other less known benzos that have even a longer half-life than Klonipin. Could they even be more effective? Anyone ever used such benzos?

Tranxene. Excellent for generalized anxiety, not useful for social phobia (for me, anyway), maybe useful at high doses for panic. Since I have social phobia, I wouldn't consider ANY benzo but Klonopin. Xanax wasn't even in the same league. Valium was useless.

Rick

 

Re: Klonopin is great, but how do you get off it? » AnneL

Posted by Dinah on January 19, 2002, at 9:23:37

In reply to Klonopin is great, but how do you get off it?, posted by AnneL on January 18, 2002, at 23:58:22

It's odd how people's responses to medications are so different. When I'm not anxious I just don't take any Klonopin and have never had any bad reaction from it. I've been off sometimes as much as a week with no problems. Of course, there may be something going on in my brain that explains both the lack of anxiety (NOT a normal state for me) and the lack of Klonopin withdrawal symptoms.

 

Do Benzos interfere with REM sleep, etc? » Mr. Scott

Posted by AnneL on January 19, 2002, at 10:29:07

In reply to Tapering Klonopin/Other Benzos, posted by Mr. Scott on January 19, 2002, at 1:21:25

Scott,
Thanks so much for your two cents! I will be discussing your suggestions with my pdoc next Thursday. Do you know if Benzos in general interfere with our natural stages of sleep (I am no expert here) like REM (rapid eye movement) which I understand is necessary for "good" quality sleep and therefore waking up feeling rested? I wake up like a zombie, stumble through making my morning espresso (latte in fact) and am late for work almost every morning because I can't get my -ss in gear. Some cognitive dulling which is relieved by liberal doses of caffiene. I don't remember when I have been able to tolerate this much caffiene without getting anxious or jittery! Thanks, Anne

 

Re: Klonopin is great, but how do you get off it?

Posted by Emme on January 19, 2002, at 11:41:08

In reply to Re: Klonopin is great, but how do you get off it? » AnneL, posted by Dinah on January 19, 2002, at 9:23:37

> It's odd how people's responses to medications are so different. When I'm not anxious I just don't take any Klonopin and have never had any bad reaction from it. I've been off sometimes as much as a week with no problems. Of course, there may be something going on in my brain that explains both the lack of anxiety (NOT a normal state for me) and the lack of Klonopin withdrawal symptoms.

It's the same for me. I use it every day, but my dosage varies a lot depending on my needs. I may need more than 1 mg one day, 0.5 mg or 0.25 mg another. There just never seems to be any negative effects from changing the dosage on an as-needed basis. Based on this, I suspect that if I reach of state of really low anxiety, I won't have any problem just not taking it. Obviously, everyone's body is different and your mileage may vary. I feel lucky to have found a drug that works so easily for me.

Emme

 

Re: Do Benzos interfere with REM sleep, etc? » AnneL

Posted by Mr.Scott on January 19, 2002, at 15:15:57

In reply to Do Benzos interfere with REM sleep, etc? » Mr. Scott, posted by AnneL on January 19, 2002, at 10:29:07

Anne,

Unfortunately the cognitive dulling has not been separated from the anti-anxiety effect in any currently marketed benzodiazepine. The less potent benzos like tranxene have less cognitive dulling, and caffeine quickly reverses much of the difficulty, whereas caffiene hardly reverses the effect of klonopin in my experience. However Tranxene probably isn't too good for Panic and hypomania. Klonopin binds very tightly to receptors and is difficult to displace. Trade-offs...Trade-offs...I guess.

Benzo's shorten the amount of time one spends in late stage REM sleep in studies and may indeed account for your difficulties, or the action of the drug itself may be making you tired in the morning. Maybe you don't need it right now and to taper it sounds reasonable.

When I was flaming with anxiety and needed it I didn't notice the side effects at all, but once the anxiety subsides a bit I would begin to.
Scott

 

Re: Klonopin is great, but how do you get off it? » AnneL

Posted by manowar on January 19, 2002, at 16:44:46

In reply to Klonopin is great, but how do you get off it?, posted by AnneL on January 18, 2002, at 23:58:22

> I have been on Klonopin 1 mg. at bedtime for almost one year now, first as an anti-anxiety agent to get me through the start-up of Effexor and then as a sleep agent. I find it extremely sedating which is great for sleep.
>
> But, I haven't heard anyone talk about how it feels to miss a dose. I have not taken it on 2 or 3 ocassions when I have indulged in 3 or more alcoholic beverages, the last time being New Year's Eve. By 4AM, I was in the midst of a severe Klonopin withdrawal. I really feel for those who are addicted to drugs like heroin, etc.
> The only thing that took away the body twitching, extreme anxiety, etc., was a dose of Klonopin at 4:30 AM. It was a living hell for 30 minutes and I dread the day when I taper off of this drug. Any comments?

Hi,

1st of all, if it helps you, don't stop taking it. Why stop taking it, as long as you don't have a problem abusing it?

For me, to miss a dose is not a big deal. I may not sleep as well, and I definitely will be more agitated the next day.

BTW: As long as you don't have a problem with alcohol and you don't plan to drive, try a Klonipin with a beer or two. The beer --for me-- practically doubles the effect of the Klonipin. I just do that once in a while, when I REALLY feel like FEELING warm and fuzzy.

When I've been forced to stop taking it in the past, I cut down the dosage by .5 mg per week, and I didn't have a problem with withdrawal. Some folks would probably do themselves a favor by cutting down by just .25 mg a week. But yeah, trying to stop cold turkey is not a fun experience.

I sure can tell when I miss a dose--so I try not to. It sucks that I have to take such a physically addictive drug, but at least it doesn't seem to be psychologically addictive for me. I don't ever have a compulsion to take more than my daily dose. There is no other drug that comes close for helping me with mood stability for my cyclothymia.

Tim


 

Doesn't too much REM sleep cause depression? (nm) » Mr.Scott

Posted by manowar on January 19, 2002, at 16:52:03

In reply to Re: Do Benzos interfere with REM sleep, etc? » AnneL, posted by Mr.Scott on January 19, 2002, at 15:15:57

 

Too much REM sleep causes depression? » manowar

Posted by IsoM on January 19, 2002, at 17:43:41

In reply to Doesn't too much REM sleep cause depression? (nm) » Mr.Scott, posted by manowar on January 19, 2002, at 16:52:03

Hey, Tim, I want to hear more on that, where you heard it from, any links, etc. I've seemed to have too much REM sleep & not enough deep sleep. Maybe longer use of adrafinil will help with deep sleep, but I'd like to know more from you.

I have read that mild sleep deprivation helps depression but bounces back once the depressed person gets a good sleep again.

 

Re: Do Benzos interfere with REM sleep, etc? » Mr.Scott

Posted by Rick on January 20, 2002, at 0:34:17

In reply to Re: Do Benzos interfere with REM sleep, etc? » AnneL, posted by Mr.Scott on January 19, 2002, at 15:15:57

>Unfortunately the cognitive dulling has not been separated from the anti-anxiety effect in any currently marketed benzodiazepine.

I wonder how soon the more receptor-specific benzos being developed by Roche and others will be marketed (assuming no major problems surface). Supposedly, this new generation of benzos will provide the same anti-anxiety benefits without the side effects.

>Tranxene probably isn't too good for Panic and hypomania.

Definitely not good for social phobia either. But if my primary problem was GAD I'd go for Tranxene, pronto. Your posts describe Tranxene perfectly.

Rick

 

Re: Klonopin is great, but how do you get off it? » manowar

Posted by Rick on January 20, 2002, at 1:02:51

In reply to Re: Klonopin is great, but how do you get off it? » AnneL, posted by manowar on January 19, 2002, at 16:44:46


> I sure can tell when I miss a dose--so I try not to. It sucks that I have to take such a physically addictive drug, but at least it doesn't seem to be psychologically addictive for me. I don't ever have a compulsion to take more than my daily dose.

Sorry if this seems picky, but since benzophobes love to cry about how benzos are "addictive", I had to chime in.

The personal situation you've described doesn't sound at all like addiction, but rather dependence (in your case, a physical dependence). Addiction means you crave more and more. Assuming the benzo is providing theraputic value, there's absolutely nothing wrong with dependence, other than a period of possible distress if and when you discontinue the med. Yes, some people taking benzos for valid medicinal purposes do indeed become truly "addicted", and understandably have horror stories to tell, but this is definitely the exception to the rule.

Rick

 

Re: Do Benzos interfere with REM sleep, etc? » Rick

Posted by Mr. Scott on January 20, 2002, at 13:17:13

In reply to Re: Do Benzos interfere with REM sleep, etc? » Mr.Scott, posted by Rick on January 20, 2002, at 0:34:17

"I wonder how soon the more receptor-specific benzos being developed by Roche and others will be marketed (assuming no major problems surface). Supposedly, this new generation of benzos will provide the same anti-anxiety benefits without the side effects."

I will be the first one in Line at the pharmacy when the do come out!!

Scott

 

Re: Klonopin is great, but how do you get off it? » manowar

Posted by AnneL on January 20, 2002, at 15:39:45

In reply to Re: Klonopin is great, but how do you get off it? » AnneL, posted by manowar on January 19, 2002, at 16:44:46

Thanks Tim for your response. It sounds reasonable, if it works why not keep on taking it.
I do not feel "addicted", I do not "crave" Klonopin, but do have dependence on it. Let's put it this way, I have strong feelings about being on a medication that I "must" take or else I suffer from dreadful, tortured sleep/wake or become a jittery mess. Quite honestly, I don't know whether or not the Effexor I take would interfere with my sleep or not since I started both meds at the same time. Stopping Klonopin is a desired goal, but quite frankly I don't feel like expending the energy to taper off of it.
In my opinion, this is part of the amotivation that I feel since I started Effexor. :) Anne

 

Re: Klonopin is great, but how do you get off it? » AnneL

Posted by jimmygold70 on January 21, 2002, at 15:54:00

In reply to Re: Klonopin is great, but how do you get off it? » manowar, posted by AnneL on January 20, 2002, at 15:39:45

You want to know how to get off Klonopin relatively painlessly ?

 

Re: Klonopin is great, but how do you get off it? » Rick

Posted by manowar on January 23, 2002, at 15:32:27

In reply to Re: Klonopin is great, but how do you get off it? » manowar, posted by Rick on January 20, 2002, at 1:02:51

>
> > I sure can tell when I miss a dose--so I try not to. It sucks that I have to take such a physically addictive drug, but at least it doesn't seem to be psychologically addictive for me. I don't ever have a compulsion to take more than my daily dose.
>
> Sorry if this seems picky, but since benzophobes love to cry about how benzos are "addictive", I had to chime in.
>
> The personal situation you've described doesn't sound at all like addiction, but rather dependence (in your case, a physical dependence). Addiction means you crave more and more. Assuming the benzo is providing theraputic value, there's absolutely nothing wrong with dependence, other than a period of possible distress if and when you discontinue the med. Yes, some people taking benzos for valid medicinal purposes do indeed become truly "addicted", and understandably have horror stories to tell, but this is definitely the exception to the rule.
>
> Rick

Hi,
You're absolutely right Rick. Thanks for making that distinction. It is a VERY important distinction to make between dependence and addiction.

Thanks,

Tim

 

Re: Too much REM sleep causes depression?

Posted by manowar on January 24, 2002, at 16:56:41

In reply to Too much REM sleep causes depression? » manowar, posted by IsoM on January 19, 2002, at 17:43:41

> Hey, Tim, I want to hear more on that, where you heard it from, any links, etc. I've seemed to have too much REM sleep & not enough deep sleep. Maybe longer use of adrafinil will help with deep sleep, but I'd like to know more from you.
>
> I have read that mild sleep deprivation helps depression but bounces back once the depressed person gets a good sleep again.

Hello again IsoM,

I found a great article today on WebMD about REM sleep and depression:

Dreams May Hold Key to Beating Depression

Divorced and Blue? When Your Ex Plays Minor Dream Role, You're Healing By Jeanie Davis

WebMD Medical News

Jan. 18, 2002 -- When a marriage hits the skids, most people get depressed. But why do some recover from divorce -- get on with their lives -- while others languish, full of depression and regret?


Their dreams may hold clues that will help their recovery, says Rosalind Cartwright, PhD, chairman of psychology at Rush University and director of the Sleep Disorder Service at Rush-Presbyterian-St. Luke's Medical Center in Chicago.


Since the 1960s, Cartwright has studied dreams to better understand their purpose. Today, most researchers think dreams are "nonsense, nothing more than flotsam and jetsam floating through your mind at night," she tells WebMD. Only recently, she's come to realize that "dreams are our mood regulators."


"Most people, if they go to bed angry, upset, anxious, blue, down, having a negative mood, they feel better in the morning," Cartwright tells WebMD. "Not the depressed; they feel worse. In the morning, they're at their lowest point. Something wrong has happened overnight. They haven't mood regulated, they've gotten worse."


Cartwright chose marital separation -- certainly an emotional, life-altering event -- to test her theory. Each volunteer was "at the point that they have decided to break up the marriage," she says. Her NIH-funded study is in its sixth year.


She has analyzed dreams of 12 depressed volunteers as well as others who were not depressed. She did not tell any volunteer whether they had scored as "depressed" or not. "I didn't want them to get treatment," she tells WebMD. "I wanted to see how they got over it on their own, because most people do."


Each volunteer slept in the Rush Sleep Disorders Center for several two-night sessions over a five-month period. During those nights, they were connected to an EEG to measure brain waves and an EOG to track eye movement indicating periods of rapid eye movement (REM) sleep, when dreaming occurs.


Normally, the first period of REM sleep involves "sparse" eye movement, says Cartwright.

Depressed people typically have their first REM-dream sleep earlier in the night than non-depressed people, says Cartwright. "The first dream comes too early, and it's much too active in terms of eye movement. Their eyes are going off like fireworks, like they're watching a ping pong game, really rapid."


Cartwright and colleagues woke up each volunteer five minutes into the REM/dream period, to ask about their dream. She also saw the volunteers in her office at the beginning, middle, and end of the study period to see how they were doing. None of the volunteers received any psychotherapy or drugs during the study.


During the five months, nine of the 12 depressed people improved significantly enough that they no longer tested as depressed.


The role of the ex-spouse in the dreams signified much about this healing process, she says.

The ex-spouse was present in everyone's dreams at first, along with a lot of negative feelings, anger, unhappiness, missing them, she says.


But toward the end of the study, it was clear that those getting over the depression had put the ex-spouse at a distance.


"The ex-spouse 'character' was there," says Cartwright, "but in a way that showed they were essentially unhooked from the relationship. It was no a longer reference point for how they felt about themselves or how they felt about a new person in their lives. It was irrelevant."


"It was more like, 'Thank goodness I don't have to pay attention to what he says anymore. I'm very independent, I don't have to ask his permission, don't have to worry about what he's doing. If I'm dating, I don't have to worry what he thinks about it,'" she says. "It's not that they had forgotten the person, but were enjoying reclaiming who they were, enjoying a sense of liberty."


Those who were depressed were still having negative, anxious dreams about the ex-spouse, she says.


The sheer action of waking people up during anxious dreams helped get them past the depression, Cartwright tells WebMD.


"It stops an abnormal process from continuing," she says. "Depressed people don't solve problems during their dreams, like other people do, they pile up their troubles, and the last dream of the night is the worst. They wake up in a worse mood if you let them sleep through those dreams. But if you interrupt them, they normalize and feel better in the morning."


Try it at home, Cartwright says.


With a little help from some friends, she's invented what she calls a "home dream recorder." It's not on the market just yet, and won't be until she has published her study results.


The home dream recorder has an EOG monitor and a movement monitor, so it's clear whether the person is awake or asleep. "If they're still and their eyes are moving, they're probably dreaming," she says. An alarm is programmed to go off when the EOG shows eyes are moving for five minutes. The person speaks their dream into a voice-activated tape recorder, then the equipment resets automatically. Next time REM sleep begins, the recorder activates again.


"It's the do-it-yourself approach," she says.


But it's not for everyone, Cartwright tells WebMD. "People with a history of serious depression, childhood abuse, no good love relationships, need some help rebuilding."


Eric Nofzinger, MD, is a sleep disorders specialist and associate professor of psychiatry with the University of Pittsburgh School of Medicine. He has conducted functional brain imaging studies during REM sleep, and those studies too have shown that the "emotion areas" of the brain are indeed very active in the dreams of people who are depressed. He has followed Cartwright's work for a number of years.


"There is merit to her theory," Nofzinger tells WebMD. "The work she has done is very important, novel, and really is some of the only work that I know of that is trying to understand what is happening with our emotional character when we're asleep at night."


But other research has shown that while sleep-depriving a depressed person improves their mood, it's only in the short term, he says. "The effects are not long lasting, they generally reverse after the second or third day of sleep deprivation."


"I don't think anybody is at the point of saying that sleep deprivation or altering dreams is the best thing in the long-term treatment of depression," says Nofzinger. "There are a lot of things that do work, like medication and psychotherapy, and those are very well validated as the mainstay of treatment for depression. I see her work as an interesting theory that requires validation."

 

Re: Klonopin -the drug of kings » Rick

Posted by Jerry Ryan on August 19, 2002, at 4:54:19

In reply to Re: Klonopin -the drug of kings » manowar, posted by Rick on January 18, 2002, at 2:12:45

Hey dude. i take 1.5mg of Klonipin each day. If I was not on Klonipin (or some other benzo) I would be paranoid, agitated and occasionally violent. The benzos have been a godsend to me. i refused to take them for years, against my Dr.s advice, not wanting to take DRUGS! But now I am much more mellow, drink less beer and have become a human being again. I am a person with suicidal and homicidal tenencies. This particular med has reduced it and kept me out ouf the nuthouse or prison. I am an electrical engineer with a 150 IQ. I have discussed this with several others that have similar IQ's. When your IQ exceeds a certain level, you begin to see movies within your mind. They can become a source of torment. Everything is a picture. Words are trivial. But the Klonipin makes the incessant torment tolerable. Just my thoughts. Thanks for your thread.

PS why are you guys so paranoid. It took me some time to register. What is the deal. I have a packet sniffer on my WAN interface and could most likely hack you given enough time. It is not profitable though. Please relax. I like this place.
\
The Master of Disaster,

Jerry Ryan
(845) 566-4189 if anyone needs a sympathetic ear. I understand.


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