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Dr. Bob is Robert Hsiung, MD,
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Posted by patricia on December 24, 1999, at 18:16:34
In reply to Re: Reboxetine (Edronax) , posted by Dina on March 16, 1999, at 2:57:30
> I'd also like to know about Reboxetine in hard-to-treat, refractory depression, and how someone in the US can get a scrip. (Hey, flights to England are cheap these days, anyone know a doc interested in a *really* challenging case..?)
>
> Thanks,
> -dina.
> dgamboni@juno.comI have just found this page, very interesting, and as I live in the UK and my doctor has just put me on this drug two months ago, I was wondering why it is not prescribed in the US willingly. I suffer mainly from anxiety which seems to affect my balance when walking outside, etc., and I can honestly say that this drug has quite miraculously made me feel so much better the past couple of weeks. Anybody else with this problem? I would like to hear from you. Thaks, Patricia.
Posted by Scott L. Schofield on December 27, 1999, at 17:08:12
In reply to Re: Reboxetine (Edronax) , posted by fran on December 27, 1999, at 12:52:16
> > > Has anyone heard of reboxetine used in combination with
other medicines, specifically Zoloft and nortriptyline?I am sorry, but I do not know anyone taking this combination. My doctor has said that theoretically, there should be no reason why reboxetine cannot be combined with an MAO-inhibitor. Combining an SSRI (Selective Serotonin Reuptake Inhibitor) like Zoloft with a more noradrenergic reuptake inhibitor like nortriptyline is a good combination for people for whom an SSRI alone is ineffective. Reboxetine is a potent SNRI (Selective Norepinephrine Reuptake Inhibitor). Reboxetine plus either Zoloft or nortriptyline sound like good combinations, but you and your doctor will probably have to research it further. Nortriptyline does inhibit the reuptake of serotonin to some extent. Other SNRIs would include Ludiomil (maprotiline) and desipramine (Norpramin).
> > Hello,
> > Excuse me for my bad English, but I'm from Belgium.Your English is very good!
> > About Edronax (reboxetine), my friend takes a combination of 2 MAOI's (Iprocloside and Nardalzine) in combination with Edronax. She responds very well to this combination therapy. She's had major depression for several years now, and this is the first time she could be helped. She feels much better now and only has few side effects.
Do Iprocloside and Nardalzine have other names?
This is the second time I have seen the combining of two MAOIs. Does anyone have more information about this?
Thank-you.- Scott
Posted by Bruce on January 3, 2000, at 8:10:48
In reply to Re: Reboxetine (Edronax) , posted by Ture Peterby on January 2, 2000, at 6:16:05
My experience (and others reporting on this board)on Reboxetine at a low dose (4 mg/day)
is that it will definitely produce sexual side effects and plenty of urinary retention.Search Psycho-Babble for posts from Luke, Bruce, and others who tried Reboxetine - the
months of October/November would be good.I don't know how to reconcile my experience and those of Psycho-Babble's contributors with
the official trials - they seem quite far apart. It is effective, though.Bruce
Posted by Frymet on January 3, 2000, at 15:33:26
In reply to Re: Reboxetine (Edronax) , posted by Ture Peterby on January 2, 2000, at 6:16:05
I would like to hear from those who are/were taking Reboxetine, if the anticholinergic side effects ie dry mouth, constipation, hypotension etc. are similar to tricyclics ( eg. imipramine, pamelor).
Also what other side effects people have eperienced beside sexual dysfunction.
Posted by Peter on January 4, 2000, at 15:53:02
In reply to Reboxetine side effects, posted by Frymet on January 3, 2000, at 15:33:26
I could only get up to 4 mg because the constipation was so bad! I tried a number of Over the Counter remedies but got very little relief. I just couldn't stick with Reboxetine. Good Luck. Peter
Posted by torchgrl on January 5, 2000, at 23:38:29
In reply to Re: Reboxetine side effects, posted by Peter on January 4, 2000, at 15:53:02
The main side effects I've noticed are constipation, some sexual dysfunction, dry mouth, frequent flushing (not sweating, just getting really hot, usually just my face), increased heart-rate, and lots of insomnia--both difficulty falling asleep and staying asleep. The insomnia is what really gets to me, and since I'm part of a study, I haven't been able to take anything to counteract it, unfortunately. The reboxetine has helped a little, but not nearly as much as I'd hoped--I don't think I'm going to stay on it now that the study has finished, especially since I can't augment it with anything else until the FDA has officially approved it and I can get it through normal channels :(
Posted by Caroline76 on January 24, 2001, at 8:32:15
In reply to Reboxetine side effects, posted by Frymet on January 3, 2000, at 15:33:26
For me, with reboxetine the constipation and dry mouth are not NEARLY as bad as with tricyclics. The only problem I have with it is that it gives me an almost constant heartburn. Who knows how to fight this? I'll only see my doc in two weeks...
Thanks, Caroline
Posted by Thomas on March 19, 2001, at 12:29:05
In reply to Re: Reboxetine side effects (Frymet),(heartburn), posted by Caroline76 on January 24, 2001, at 8:32:15
Hi,
for me edronax has helped alot:-)
But there are severel side effects. Dizziness is actually the worst. Ensomnia aswell, but its actually a nice change for me, as I feel I have slept my life away.Thomas
Posted by kathyG on June 27, 2001, at 23:53:09
In reply to Re: Reboxetine side effects: dizziness, posted by Thomas on March 19, 2001, at 12:29:05
Has anybody taken Imipramin and Reboxetine (edronax) together? If so, was the combination of these two antidepressants effective?
Thanks,
kathy
Posted by Dr. Bosch on August 2, 2001, at 15:49:20
In reply to Reboxetine (Edronax) , posted by Paulk on July 23, 1998, at 19:34:03
> I ordered Reboxetine only after an exhaustive internet review. I have taken many AP's over the years. It stimulated me more than any amphetamine I can vaguely recall taking decades ago. I got NO sleep, up all night pacing. Sweated like a race horse, dry mouth, severe constipation. I like the idea of a noradregergic drug, but Reboxetine, no thanx.
Posted by JohnL on August 3, 2001, at 3:43:28
In reply to Re: Reboxetine (Edronax) , posted by Dr. Bosch on August 2, 2001, at 15:49:20
> > I ordered Reboxetine only after an exhaustive internet review. I have taken many AP's over the years. It stimulated me more than any amphetamine I can vaguely recall taking decades ago. I got NO sleep, up all night pacing. Sweated like a race horse, dry mouth, severe constipation. I like the idea of a noradregergic drug, but Reboxetine, no thanx.
Dittos. Me too. Not to mention the male impotence side effect which was rather severe and quite disturbing.
For noradrenergic action, I have never come across anything that comes close to the effectiveness and lack of side effects of Adrafinil. And I've tried a bunch.
John
Posted by Paltiel on December 22, 2001, at 21:17:35
In reply to Re: Reboxetine side effects: dizziness, posted by kathyG on June 27, 2001, at 23:53:09
> Has anybody taken Imipramin and Reboxetine (edronax) together? If so, was the combination of these two antidepressants effective?
> Thanks,
> kathyTry Reboxetine 2mg in the morning and imipramine 50 at night. The imipramine rounds out the reboxetine and take the edge off the insomnia. If anyone out there is trying this, please write and say how it's going. Thanks - Paltiel
Posted by edward602 on December 26, 2001, at 17:35:21
In reply to Re: Reboxetine side effects: dizziness, posted by Paltiel on December 22, 2001, at 21:17:35
Reboxetine was the most activating, insomnia and anxiety producing drug I've ever taken. Maybe I went up too fast, 4 mg. for a week, 6 mg. for a week, then 8 mg. but by then I could not sleep without lots of tranquilizers, had night tremors and sweats, nightmares and terrible anxiety. My pdoc got me off it pretty fast. The literature on it is good but people sensitive to activating AD's have to be careful with it.
--Edward
Posted by Paltiel on February 11, 2002, at 1:43:54
In reply to Re: Reboxetine side effects: dizziness, posted by edward602 on December 26, 2001, at 17:35:21
Try less - much, much less. I get great, smooth results on 2mg a day but get flushing and palpatations on 3 mgs.
Try the lowest dose you can (1 or 2 mg) and see if you still get the antidepressant effect you want.
Posted by feelingdizzy on June 16, 2003, at 17:16:44
In reply to Reboxetine (Edronax) , posted by Paulk on July 23, 1998, at 19:34:03
Have s.a.d. took prozac for 6 months although no side effects,got depressed again.swapped to reboxetine 12mg-MAJOR SIDE EFFECTS-extreme dry mouth,severe constipation,sweating,hot flushing to body and face+just recently dizziness headaches and spaced out drunk feeling.I feel ghastly and don't know what to do-all advice/info/tips gratefully received!
Posted by Ynot on July 6, 2003, at 3:52:10
In reply to Re: Reboxetine side effects (Frymet),(heartburn), posted by Caroline76 on January 24, 2001, at 8:32:15
I have been prescribed Reboxitine as of the 3/7/2003. I am male and 38 years of age. This is in conjunction with a maximum dose of seroxat (50mg). After reading all the threads, I have decided to keep a day by day account of my useage of reboxatine, and will post it on this notice board if thats ok.This might help others who are new to this drug.
day 1 : one dose of 4mg taken in conjunction with seroxat 50mg.
effects: at the start i noticed a "discomfort" with urinating. i call it the "dribble" effect.Beware new users of making sure all urine has passed out of the urethra before zipping up, as I found it could lead to errmm wet marks on trousers. Exciteability - I was more excited and agitated (in a good way). Sexual activities :I found on trying to have sex that a feeling of erectile dysfunction was present, but perserverance paid off.A BIG thing i noticed was at the point of climax, the effect of climaxing was much more heightened, to the point of ecstatic. But I also noticed that whereas a male climaxes with sperm ejaculation combined with a feeling of euphoria, my sperm was released roughly three to five seconds prior to feeling of euphoria.This resulted in a "delayed" and "longer" feeling of euphoria. A second attempt at sex two days later produced exactly the same response.
Dry Mouth:this is a very unpleasant side effect I have with reboxetine, but one I can live with.
Sweating: I also had profuse sweating.
Insomnia: no problems with insomnia
General feelings after one weeks use : Reboxetine combined with Seroxat has definitely made me feel "perky". I can feel a marked difference in how I feel and how I approach people. I feel that I "want" to do more.
I will keep you updated with the results of week two.
Please remember: All medication is provided by a practicing GP and a Psychiatrist who work in conjuntion with each other to facillitate a drug programme suitable to MY needs. I strongly suggest that you discuss your research with your GP and seek his / her advice. I do not recommend or condone the use of drugs outside your medical GP's plan for your rehabillitation. Furthermore, my explanations here are related to me only and may not have the same effect for you. It is probable that without medical advice, the taking of any drug without medical advice could lead to adverse effects and I do not recommend you do this. I cannot be held responsible for your health because of reading my postings.
regards
Tony
ps:My last paragraph sounds like a real dampner on things, but I understand what lengths depressed people may go to to try and get "better". I know I have been there too.
Posted by mkdrma on July 24, 2003, at 21:47:36
In reply to Re: Reboxetine - new drug prescribed for me, posted by Ynot on July 6, 2003, at 3:52:10
> I have been prescribed Reboxitine as of the 3/7/2003. I am male and 38 years of age. This is in conjunction with a maximum dose of seroxat (50mg). After reading all the threads, I have decided to keep a day by day account of my useage of reboxatine, and will post it on this notice board if thats ok.This might help others who are new to this drug.
> day 1 : one dose of 4mg taken in conjunction with seroxat 50mg.> effects: at the start i noticed a "discomfort" with urinating. i call it the "dribble" effect.Beware new users of making sure all urine has passed out of the urethra before zipping up, as I found it could lead to errmm wet marks on trousers. Exciteability - I was more excited and agitated (in a good way). Sexual activities :I found on trying to have sex that a feeling of erectile dysfunction was present, but perserverance paid off.A BIG thing i noticed was at the point of climax, the effect of climaxing was much more heightened, to the point of ecstatic. But I also noticed that whereas a male climaxes with sperm ejaculation combined with a feeling of euphoria, my sperm was released roughly three to five seconds prior to feeling of euphoria.This resulted in a "delayed" and "longer" feeling of euphoria. A second attempt at sex two days later produced exactly the same response.
> Dry Mouth:this is a very unpleasant side effect I have with reboxetine, but one I can live with.
> Sweating: I also had profuse sweating.
> Insomnia: no problems with insomnia
> General feelings after one weeks use : Reboxetine combined with Seroxat has definitely made me feel "perky". I can feel a marked difference in how I feel and how I approach people. I feel that I "want" to do more.
> I will keep you updated with the results of week two.
> Please remember: All medication is provided by a practicing GP and a Psychiatrist who work in conjuntion with each other to facillitate a drug programme suitable to MY needs. I strongly suggest that you discuss your research with your GP and seek his / her advice. I do not recommend or condone the use of drugs outside your medical GP's plan for your rehabillitation. Furthermore, my explanations here are related to me only and may not have the same effect for you. It is probable that without medical advice, the taking of any drug without medical advice could lead to adverse effects and I do not recommend you do this. I cannot be held responsible for your health because of reading my postings.
> regards
> Tony
> ps:My last paragraph sounds like a real dampner on things, but I understand what lengths depressed people may go to to try and get "better". I know I have been there too.Ynot,
I would love to know how you do on this drug! I've been gathering info on it for a while, don't know anyone who's taking it.I take Effexor XR and recently increased from 150 to 300mg. I don't feel that much better and I'm blowing up like a balloon! 3 more pounds this weekend! I see my doc next week, so I'm hoping to have all the good info I can for her. I've already decreased my dose back to 150. Oh, I take it for anxiety and panic, along with depression.
Thanks!
Posted by SLS on July 27, 2003, at 23:01:07
In reply to Re: Reboxetine - new drug prescribed for me » Ynot, posted by mkdrma on July 24, 2003, at 21:47:36
Hi.
I had a very difficult time with reboxetine. At 4mg, it did nothing. At 8mg, I became much more depressed with lots of anxiety and suicidal ideation. Within 36 hours of discontinuation, this exacerbation of my condition disappeared. I know several other people who had similar experiences. However, I have read a few success stories as well.
- Scott
Posted by rod on July 29, 2003, at 8:54:45
In reply to Re: Reboxetine - new drug prescribed for me, posted by SLS on July 27, 2003, at 23:01:07
Do you know Southpark? Do you also know the little kid, whose parent have a coffee shop and always give him plenty of coffee? This boy is always trembling, screaming sometimes for no reason and sees tiny dwarfs who steel the underpants of other people. Maybe you know this episode.
When I was on Reboxetine for 6 month, some of my "friends" called me under the boys name. haha very funny. But the Reboxetine was the worst med ever for me and I can not exclude it did some permanent harm to me. who knows. I was extremly nervous, anxious and was unable to relax. Just like this boy. It worked well in the first month, but got constantly worse at the following months, and I was too scared to get off, because I thought it would get even more worse without.
Although the doctors in europe treat Reboxetine as the drug for treatment resistant depressives and some doctors call it a miracle drug.good luck
Roland
Posted by lesliekay on July 30, 2003, at 5:11:11
In reply to Re: Reboxetine - new drug prescribed for me, posted by rod on July 29, 2003, at 8:54:45
sounds nasty!!!The crap we put ourselves through!
Posted by allysssa on August 4, 2003, at 5:58:03
In reply to Re: Reboxetine - new drug prescribed for me » Ynot, posted by mkdrma on July 24, 2003, at 21:47:36
thanks ynot for your info and progress on reboxtine. I only heard of the drug today after a visit to my Doctor. I suffer from manic depression and have basically been feeling at odds with life for the last 4 years. (althougth I was first hospitalized 22 years ago when i was 16) Will be tappering off the aropax over 1 week, then 1 week without meds, then i start the reboxetine. I will try and find out a little more about the effects etc, by using this web sight. Thankyou again for your info, allysssa.
Posted by starflower on January 26, 2004, at 9:53:10
In reply to Re: Reboxetine - off aropax, r'xetine in 2/52 » mkdrma, posted by allysssa on August 4, 2003, at 5:58:03
I'm really sensitive to activating a-ds and so far reboxetine seems fine for me. I'm on 4mg in a split dose and have been for a week. Few very slight side effects - slight dry mouth, slight constipation and occasional waking in the night. I do feel much brighter and will stay on this dose unless I feel the effects lessening after another week or so.
I think it's advisable with any med to go really slowly to start with. Docs tend to whack us on therapeutic doses immediately so you end up with a whole host of side effects to deal with when you're at your lowest. In my experience, some of them can be avoided with a gradual taper on, as well as off. Just as I wouldn't advise anyone to stop suddenly, I wouldn't advise anyone to start abruptly either!
Posted by micro on January 27, 2004, at 8:01:27
In reply to Re: Reboxetine - off aropax, r'xetine in 2/52, posted by starflower on January 26, 2004, at 9:53:10
> I'm really sensitive to activating a-ds and so far reboxetine seems fine for me. I'm on 4mg in a split dose and have been for a week. Few very slight side effects - slight dry mouth, slight constipation and occasional waking in the night. I do feel much brighter and will stay on this dose unless I feel the effects lessening after another week or so.
>
> I think it's advisable with any med to go really slowly to start with. Docs tend to whack us on therapeutic doses immediately so you end up with a whole host of side effects to deal with when you're at your lowest. In my experience, some of them can be avoided with a gradual taper on, as well as off. Just as I wouldn't advise anyone to stop suddenly, I wouldn't advise anyone to start abruptly either!Hello, I hope everyone reads the above post! Almost every psychotropic med can be titrated up more gradually than the recommended manufacturers dosing. A word to those on klonopin especially, it can be taken in halves or pill cut into fourths if necessary to help reduce daytime drowsiness. For outpatients, this seems to be a logical means of avoiding work related issues[side effects which interfere with normal functioning]. A skillful psychopharm should understand this, unfortunately many do not!
Request slower titration yourselves if you experience side effects very quickly!!! The se's will occur early in treatment as a norm if they are going to occur, particularly the first 2 weeks, [the way most pdocs and pcp's rx]. BY the book, doesn't always work with psychotropics for a variety of reasons. Exercise also greatly effects pharmacology. Please read " Sports and Exercise Pharmacology" by Stan Reents Pharmd. Published by Human Kinetics for $45. At www.humankinetics.com if you exercise at all. Godd Luck! Micro.
Posted by trishay on March 7, 2004, at 4:51:46
In reply to Reboxetine (Edronax) , posted by Paulk on July 23, 1998, at 19:34:03
Just started on edronax. Had really bad long lasting side effects going off effexor xr. was on 450mg day gradually went down to 75mg per day over 4 weeks. then had exceptionally bad withdrawal that lasted for 10 weeks. Hope edronax works better. Makes you sweat lots. Am very depressed too.
Posted by Sad Panda on March 8, 2004, at 4:44:08
In reply to Re: Reboxetine (Edronax), posted by trishay on March 7, 2004, at 4:51:46
> Just started on edronax. Had really bad long lasting side effects going off effexor xr. was on 450mg day gradually went down to 75mg per day over 4 weeks. then had exceptionally bad withdrawal that lasted for 10 weeks. Hope edronax works better. Makes you sweat lots. Am very depressed too.
>
>Hi There! :)
Please keep us posted on how you go with Edronax. I'm actually thinking about taking it myself on top of Effexor.
Cheers,
Panda.
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