Posted by SLS on March 10, 2005, at 11:09:09
In reply to Re: Sometimes there's no choice » SLS, posted by Sarah T. on March 9, 2005, at 22:24:52
> Hi Scott. I've tried both Parnate and Nardil, but I was on Nardil for a very short period. I was on Parnate several times, for at least 6 months each time. Can you tell me a bit about Nardil?
The first time I took Nardil, I experienced a sort of sedation and fatigue during the first few weeks, whereupon it became activating. I could actually catch a bit of an energy boost within minutes of dosing. When it worked, I liked it much better than Parnate. Parnate leaves me with residual anhedonia. Nardil was definitely more of a "mood-brightener" than Parnate for me. I believe that Nardil is somewhat more pro-serotonergic than Parnate. I am susceptible to serotonin syndrome when combining imipramine with Nardil, but not with Parnate. Perhaps it is the pro-serotinergic effects of Nardil that account for the mood-brightening I experience with it. That's nothing more than a silly guess.
I believe most of, although not all of, the weight gain with Nardil is the result of increased carbohydrate intake resulting from cravings. The rest might be metabolic. Nardil might mess around with glucose/insulin dynamics. Another silly guess.
> Both the dopamine agonists and Parnate can cause daytime sleep attacks.
I never made this connection. You are right.
> I wonder what it is about all that excess dopamine that causes this problem is susceptible people.
Hmm. Interesting.
With DA receptor agonists, I think it might have something to do with pre-synaptic receptor downregulation. One last silly guess.
:-)
- Scott
poster:SLS
thread:463648
URL: http://www.dr-bob.org/babble/wdrawl/20050228/msgs/469222.html